Quality of life disparities among Mexican people with systemic lupus erythematosus.
Higher prevalence and worst outcome have been reported among people with systemic lupus erythematosus with non-European ancestries, with both genetic and socioeconomic variables as contributing factors. In Mexico, studies assessing the inequities related to quality of life for Systemic Lupus Erythem...
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| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLOS Digital Health |
| Online Access: | https://doi.org/10.1371/journal.pdig.0000706 |
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| author | Ana Laura Hernández-Ledesma Domingo Martínez Elizabeth Fajardo-Brigido Talía V Román-López Karen J Nuñez-Reza Andrea Y Tapia-Atilano Sandra V Vera Del Valle Donají Domínguez-Zúñiga Lizbet Tinajero-Nieto Angélica Peña-Ayala Estefania Torres-Valdez Gabriel Frontana-Vázquez María Gutiérrez-Arcelus Florencia Rosetti Sarael Alcauter Miguel E Rentería Alejandra E Ruiz-Contreras Deshiré Alpízar-Rodríguez Alejandra Medina-Rivera |
| author_facet | Ana Laura Hernández-Ledesma Domingo Martínez Elizabeth Fajardo-Brigido Talía V Román-López Karen J Nuñez-Reza Andrea Y Tapia-Atilano Sandra V Vera Del Valle Donají Domínguez-Zúñiga Lizbet Tinajero-Nieto Angélica Peña-Ayala Estefania Torres-Valdez Gabriel Frontana-Vázquez María Gutiérrez-Arcelus Florencia Rosetti Sarael Alcauter Miguel E Rentería Alejandra E Ruiz-Contreras Deshiré Alpízar-Rodríguez Alejandra Medina-Rivera |
| author_sort | Ana Laura Hernández-Ledesma |
| collection | DOAJ |
| description | Higher prevalence and worst outcome have been reported among people with systemic lupus erythematosus with non-European ancestries, with both genetic and socioeconomic variables as contributing factors. In Mexico, studies assessing the inequities related to quality of life for Systemic Lupus Erythematosus patients remain sparse. This study aims to assess the inequities related to quality of life in a cohort of Mexican people with SLE. This study included 942 individuals with SLE from the Mexican Lupus Registry (LupusRGMX) and two healthy control groups. Self-answered surveys were collected via the Research Electronic Data Capture platform between May 2021 and January 2023. Data was analyzed as a cross-sectional study. A random forest model was implemented to assess potential predictive variables. Permutation tests were performed to analyze the effect health providers had on diagnosis lag and quality of life's differences among socioeconomic levels. Partial correlation analysis between the number of patients and rheumatologists registered was also performed. Systemic Lupus Erythematosus participants had significantly lower quality of life than healthy people (p-values < 0.0001). Socioeconomic status, delay in diagnosis, and corticosteroid consumption were the factors that influenced QoL the most (RMSE = 9.53 with the importance variable validated); lower quality of life was associated with lower socioeconomic status (p-value < 0.0001). Disparities in health services were reflected in longer diagnosis time among people with public health providers (p-value = 0.0419). A significant association between diagnosed patients and available rheumatologists by geographical state was observed (ρ = 0.4, p-value = 0.0259), which can be translated into restricted access to specialists. Since most of our cohort exhibited low socioeconomic status, it is important to consider them as a vulnerable population; this study settles the necessity to deepen the effects of the socioeconomic disparities, allowing to design public policies and strategies aimed to reduce Systemic Lupus Erythematosus disparities, therefore improving quality of life of Mexican people with Systemic Lupus Erythematosus. |
| format | Article |
| id | doaj-art-580c7af130614770b098f37230bde3cb |
| institution | Kabale University |
| issn | 2767-3170 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Digital Health |
| spelling | doaj-art-580c7af130614770b098f37230bde3cb2025-02-05T05:33:36ZengPublic Library of Science (PLoS)PLOS Digital Health2767-31702025-01-0141e000070610.1371/journal.pdig.0000706Quality of life disparities among Mexican people with systemic lupus erythematosus.Ana Laura Hernández-LedesmaDomingo MartínezElizabeth Fajardo-BrigidoTalía V Román-LópezKaren J Nuñez-RezaAndrea Y Tapia-AtilanoSandra V Vera Del ValleDonají Domínguez-ZúñigaLizbet Tinajero-NietoAngélica Peña-AyalaEstefania Torres-ValdezGabriel Frontana-VázquezMaría Gutiérrez-ArcelusFlorencia RosettiSarael AlcauterMiguel E RenteríaAlejandra E Ruiz-ContrerasDeshiré Alpízar-RodríguezAlejandra Medina-RiveraHigher prevalence and worst outcome have been reported among people with systemic lupus erythematosus with non-European ancestries, with both genetic and socioeconomic variables as contributing factors. In Mexico, studies assessing the inequities related to quality of life for Systemic Lupus Erythematosus patients remain sparse. This study aims to assess the inequities related to quality of life in a cohort of Mexican people with SLE. This study included 942 individuals with SLE from the Mexican Lupus Registry (LupusRGMX) and two healthy control groups. Self-answered surveys were collected via the Research Electronic Data Capture platform between May 2021 and January 2023. Data was analyzed as a cross-sectional study. A random forest model was implemented to assess potential predictive variables. Permutation tests were performed to analyze the effect health providers had on diagnosis lag and quality of life's differences among socioeconomic levels. Partial correlation analysis between the number of patients and rheumatologists registered was also performed. Systemic Lupus Erythematosus participants had significantly lower quality of life than healthy people (p-values < 0.0001). Socioeconomic status, delay in diagnosis, and corticosteroid consumption were the factors that influenced QoL the most (RMSE = 9.53 with the importance variable validated); lower quality of life was associated with lower socioeconomic status (p-value < 0.0001). Disparities in health services were reflected in longer diagnosis time among people with public health providers (p-value = 0.0419). A significant association between diagnosed patients and available rheumatologists by geographical state was observed (ρ = 0.4, p-value = 0.0259), which can be translated into restricted access to specialists. Since most of our cohort exhibited low socioeconomic status, it is important to consider them as a vulnerable population; this study settles the necessity to deepen the effects of the socioeconomic disparities, allowing to design public policies and strategies aimed to reduce Systemic Lupus Erythematosus disparities, therefore improving quality of life of Mexican people with Systemic Lupus Erythematosus.https://doi.org/10.1371/journal.pdig.0000706 |
| spellingShingle | Ana Laura Hernández-Ledesma Domingo Martínez Elizabeth Fajardo-Brigido Talía V Román-López Karen J Nuñez-Reza Andrea Y Tapia-Atilano Sandra V Vera Del Valle Donají Domínguez-Zúñiga Lizbet Tinajero-Nieto Angélica Peña-Ayala Estefania Torres-Valdez Gabriel Frontana-Vázquez María Gutiérrez-Arcelus Florencia Rosetti Sarael Alcauter Miguel E Rentería Alejandra E Ruiz-Contreras Deshiré Alpízar-Rodríguez Alejandra Medina-Rivera Quality of life disparities among Mexican people with systemic lupus erythematosus. PLOS Digital Health |
| title | Quality of life disparities among Mexican people with systemic lupus erythematosus. |
| title_full | Quality of life disparities among Mexican people with systemic lupus erythematosus. |
| title_fullStr | Quality of life disparities among Mexican people with systemic lupus erythematosus. |
| title_full_unstemmed | Quality of life disparities among Mexican people with systemic lupus erythematosus. |
| title_short | Quality of life disparities among Mexican people with systemic lupus erythematosus. |
| title_sort | quality of life disparities among mexican people with systemic lupus erythematosus |
| url | https://doi.org/10.1371/journal.pdig.0000706 |
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