Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma
An elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture. One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmun...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/9601094 |
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| author | Daniel Benharroch Miriam Zekzer Karen Nalbandyan |
| author_facet | Daniel Benharroch Miriam Zekzer Karen Nalbandyan |
| author_sort | Daniel Benharroch |
| collection | DOAJ |
| description | An elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture. One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmunoblastic T-cell lymphoma. The other component, revealing spindle cells forming whorls with immunostaining for CD21, CD23, and fascin, might be an integral part of this T-cell lymphoma. However, due to the often massive involvement of the nodal tissue by these follicular dendritic cells, these areas were questionably suggestive of involvement by follicular dendritic cell sarcoma. We raise herein the issue of the borderline area between advanced follicular dendritic cell expansion in angioimmunoblastic T-cell lymphoma and a massive follicular dendritic cell proliferation consistent with follicular dendritic cells sarcoma, in the absence of a genomic analysis. |
| format | Article |
| id | doaj-art-580195cb3e6747dea7b006928b417c34 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-580195cb3e6747dea7b006928b417c342025-02-03T01:26:22ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/96010949601094Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell SarcomaDaniel Benharroch0Miriam Zekzer1Karen Nalbandyan2Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Hematology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelAn elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture. One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmunoblastic T-cell lymphoma. The other component, revealing spindle cells forming whorls with immunostaining for CD21, CD23, and fascin, might be an integral part of this T-cell lymphoma. However, due to the often massive involvement of the nodal tissue by these follicular dendritic cells, these areas were questionably suggestive of involvement by follicular dendritic cell sarcoma. We raise herein the issue of the borderline area between advanced follicular dendritic cell expansion in angioimmunoblastic T-cell lymphoma and a massive follicular dendritic cell proliferation consistent with follicular dendritic cells sarcoma, in the absence of a genomic analysis.http://dx.doi.org/10.1155/2017/9601094 |
| spellingShingle | Daniel Benharroch Miriam Zekzer Karen Nalbandyan Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma Case Reports in Hematology |
| title | Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma |
| title_full | Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma |
| title_fullStr | Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma |
| title_full_unstemmed | Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma |
| title_short | Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma |
| title_sort | angioimmunoblastic t cell lymphoma a questionable association with follicular dendritic cell sarcoma |
| url | http://dx.doi.org/10.1155/2017/9601094 |
| work_keys_str_mv | AT danielbenharroch angioimmunoblastictcelllymphomaaquestionableassociationwithfolliculardendriticcellsarcoma AT miriamzekzer angioimmunoblastictcelllymphomaaquestionableassociationwithfolliculardendriticcellsarcoma AT karennalbandyan angioimmunoblastictcelllymphomaaquestionableassociationwithfolliculardendriticcellsarcoma |