A bovine pulmosphere model and multiomics reveal early host response signature in tuberculosis

A bovine pulmosphere model and multiomics reveal early host response signature in tuberculosis

Abstract Early interactions between tubercle bacilli and lung cells are critical in tuberculosis (TB) pathogenesis. Conventional two-dimensional cell cultures fail to replicate the multicellular complexity of lungs. We introduce a three-dimensional pulmosphere model for Mycobacterium tuberculosis in...

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Bibliographic Details
Main Authors: Vinay Bhaskar, Rishi Kumar, Manas Ranjan Praharaj, Sripratyusha Gandham, Hemanta Kumar Maity, Uttam Sarkar, Bappaditya Dey
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07883-6
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