The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018)
Objective To explore the risk factors for uric acid-lowering therapy-resistant gout (UALT-RG) and its relationships with the estimated glomerular filtration rate (eGFR), body roundness index (BRI), and visceral adiposity index (VAI) via 2007–2018 National Health and Nutrition Examination Survey (NHA...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2441398 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087221380841472 |
|---|---|
| author | Mengyuan Zhu Xingqiang Wang Zining Peng Weitian Yan Qian Deng Meihui Li Nian Liu Ling Zhang |
| author_facet | Mengyuan Zhu Xingqiang Wang Zining Peng Weitian Yan Qian Deng Meihui Li Nian Liu Ling Zhang |
| author_sort | Mengyuan Zhu |
| collection | DOAJ |
| description | Objective To explore the risk factors for uric acid-lowering therapy-resistant gout (UALT-RG) and its relationships with the estimated glomerular filtration rate (eGFR), body roundness index (BRI), and visceral adiposity index (VAI) via 2007–2018 National Health and Nutrition Examination Survey (NHANES) data.Methods We calculated the BRI using waist circumference and standing height; the VAI using triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI); and the eGFR from serum creatinine levels. We also collected gout data. We explored the relationships of the eGFR, BRI, and VAI with UALT-RG risk via univariable and multivariable weighted logistic regression, trend analysis, and restricted cubic splines.Results Among the 1,811 patients with gout, ∼9.08% had UALT-RG; these patients were more likely to have obesity, comorbid diabetes (36% [27–47%] vs. 25% [22–28%]) or impaired kidney function (eGFR < 60 mL/min/1.73 m2, 34.5% [27–43%] vs. 22.5% [20–26%]); be former smokers; and take colchicine (10% [5.6–19%] vs. 4.3% [2.8–6.7%]). Logistic regression and trend analysis suggested that an elevated BRI and decreased eGFR were independent risk factors and potential screening indicators for UALT-RG. Restricted cubic spline analysis revealed a negative linear trend between the eGFR and UALT-RG risk (p-overall < 0.0001) and a significant positive correlation between the BRI and UALT-RG risk (p-overall < 0.0001).Conclusion An increased BRI and decreased eGFR may be independent risk factors and assessment indicators for UALT-RG in U.S. adults. It is necessary to monitor serum urate levels more closely and conduct early multidisciplinary comanagement when gout is comorbid with visceral obesity and chronic kidney disease stages 3–5. |
| format | Article |
| id | doaj-art-57dd3fbd07f649f093471af512f44708 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-57dd3fbd07f649f093471af512f447082025-02-06T06:41:45ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2024.2441398The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018)Mengyuan Zhu0Xingqiang Wang1Zining Peng2Weitian Yan3Qian Deng4Meihui Li5Nian Liu6Ling Zhang7The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, P. R. ChinaDepartment of Rheumatology, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, P. R. ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, P. R. ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, P. R. ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, P. R. ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, P. R. ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, P. R. ChinaThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, P. R. ChinaObjective To explore the risk factors for uric acid-lowering therapy-resistant gout (UALT-RG) and its relationships with the estimated glomerular filtration rate (eGFR), body roundness index (BRI), and visceral adiposity index (VAI) via 2007–2018 National Health and Nutrition Examination Survey (NHANES) data.Methods We calculated the BRI using waist circumference and standing height; the VAI using triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI); and the eGFR from serum creatinine levels. We also collected gout data. We explored the relationships of the eGFR, BRI, and VAI with UALT-RG risk via univariable and multivariable weighted logistic regression, trend analysis, and restricted cubic splines.Results Among the 1,811 patients with gout, ∼9.08% had UALT-RG; these patients were more likely to have obesity, comorbid diabetes (36% [27–47%] vs. 25% [22–28%]) or impaired kidney function (eGFR < 60 mL/min/1.73 m2, 34.5% [27–43%] vs. 22.5% [20–26%]); be former smokers; and take colchicine (10% [5.6–19%] vs. 4.3% [2.8–6.7%]). Logistic regression and trend analysis suggested that an elevated BRI and decreased eGFR were independent risk factors and potential screening indicators for UALT-RG. Restricted cubic spline analysis revealed a negative linear trend between the eGFR and UALT-RG risk (p-overall < 0.0001) and a significant positive correlation between the BRI and UALT-RG risk (p-overall < 0.0001).Conclusion An increased BRI and decreased eGFR may be independent risk factors and assessment indicators for UALT-RG in U.S. adults. It is necessary to monitor serum urate levels more closely and conduct early multidisciplinary comanagement when gout is comorbid with visceral obesity and chronic kidney disease stages 3–5.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2441398Glomerular filtration ratebody roundness indexrefractory gouthyperuricemiaobesityNHANES |
| spellingShingle | Mengyuan Zhu Xingqiang Wang Zining Peng Weitian Yan Qian Deng Meihui Li Nian Liu Ling Zhang The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018) Renal Failure Glomerular filtration rate body roundness index refractory gout hyperuricemia obesity NHANES |
| title | The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018) |
| title_full | The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018) |
| title_fullStr | The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018) |
| title_full_unstemmed | The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018) |
| title_short | The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018) |
| title_sort | role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid lowering therapy resistant gout in u s adults evidence from the national health and nutrition examination survey 2007 2018 |
| topic | Glomerular filtration rate body roundness index refractory gout hyperuricemia obesity NHANES |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2441398 |
| work_keys_str_mv | AT mengyuanzhu theroleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT xingqiangwang theroleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT ziningpeng theroleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT weitianyan theroleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT qiandeng theroleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT meihuili theroleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT nianliu theroleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT lingzhang theroleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT mengyuanzhu roleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT xingqiangwang roleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT ziningpeng roleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT weitianyan roleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT qiandeng roleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT meihuili roleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT nianliu roleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 AT lingzhang roleoftheestimatedglomerularfiltrationrateandbodyroundnessindexintheriskassessmentofuricacidloweringtherapyresistantgoutinusadultsevidencefromthenationalhealthandnutritionexaminationsurvey20072018 |