<i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome
Hypertension, type 2 diabetes (T2D), and obesity raise an individual’s risk of suffering from diseases associated with metabolic syndrome (MS). In humans, enzymes that play a role in the prevention and development of MS include angiotensin converting enzyme (ACE-1) associated with hypertension, α-am...
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2025-01-01
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| description | Hypertension, type 2 diabetes (T2D), and obesity raise an individual’s risk of suffering from diseases associated with metabolic syndrome (MS). In humans, enzymes that play a role in the prevention and development of MS include angiotensin converting enzyme (ACE-1) associated with hypertension, α-amylase associated with T2D, and lipase linked to the development of obesity. Seaweeds are a rich source of bioactives consisting of proteins/peptides, polysaccharides, and lipids. This study examined the potential of seaweed-derived bioactives from <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as inhibitors of ACE-1, α-amylase, and lipase. In vitro enzyme inhibitory assays were used to quantify the bioactivity of the seaweed extracts and compare their half-maximal inhibitory (IC<sub>50</sub>) values to recognised positive control enzyme inhibitory drugs captopril© (an ACE-1 inhibitor), acarbose (an α-amylase inhibitor), and orlistat (a lipase inhibitor). Three seaweed extracts displayed enzyme inhibitory activities equal to, or more effective than, the reference positive control drugs. These were <i>P. palmata</i> peptides (ACE-1 IC<sub>50</sub> 94.29 ± 3.07 µg/mL, vs. captopril© 91.83 ± 2.68 µg/mL); <i>A. esculenta</i> polyphenol extract (α-amylase IC<sub>50</sub> 147.04 ± 9.72 µg/mL vs. acarbose 185.67 ± 12.48 µg/mL, and lipase IC<sub>50</sub> 106.21 ± 6.53 µg/mL vs. orlistat 139.74 ± 9.33 µg/mL); and <i>U. lactuca</i> polysaccharide extract (α-amylase IC<sub>50</sub> 168.06 ± 10.53 µg/mL vs. acarbose 185.67 ± 12.48 µg/mL). Proximate analysis also revealed that all three seaweeds were a good source of protein, fibre, and polyunsaturated essential fatty acids (PUFAs). These findings highlight the potential of these seaweeds in the management of diseases associated with MS and as foods. |
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| spelling | doaj-art-57d1832e4fea4650a939245277f0e00d2025-01-24T13:33:08ZengMDPI AGFoods2304-81582025-01-0114228410.3390/foods14020284<i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic SyndromeEmer Shannon0Maria Hayes1Food BioSciences, Teagasc Food Research Centre, Dunsinea Lane, Ashtown, D15 DY05 Dublin, IrelandFood BioSciences, Teagasc Food Research Centre, Dunsinea Lane, Ashtown, D15 DY05 Dublin, IrelandHypertension, type 2 diabetes (T2D), and obesity raise an individual’s risk of suffering from diseases associated with metabolic syndrome (MS). In humans, enzymes that play a role in the prevention and development of MS include angiotensin converting enzyme (ACE-1) associated with hypertension, α-amylase associated with T2D, and lipase linked to the development of obesity. Seaweeds are a rich source of bioactives consisting of proteins/peptides, polysaccharides, and lipids. This study examined the potential of seaweed-derived bioactives from <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as inhibitors of ACE-1, α-amylase, and lipase. In vitro enzyme inhibitory assays were used to quantify the bioactivity of the seaweed extracts and compare their half-maximal inhibitory (IC<sub>50</sub>) values to recognised positive control enzyme inhibitory drugs captopril© (an ACE-1 inhibitor), acarbose (an α-amylase inhibitor), and orlistat (a lipase inhibitor). Three seaweed extracts displayed enzyme inhibitory activities equal to, or more effective than, the reference positive control drugs. These were <i>P. palmata</i> peptides (ACE-1 IC<sub>50</sub> 94.29 ± 3.07 µg/mL, vs. captopril© 91.83 ± 2.68 µg/mL); <i>A. esculenta</i> polyphenol extract (α-amylase IC<sub>50</sub> 147.04 ± 9.72 µg/mL vs. acarbose 185.67 ± 12.48 µg/mL, and lipase IC<sub>50</sub> 106.21 ± 6.53 µg/mL vs. orlistat 139.74 ± 9.33 µg/mL); and <i>U. lactuca</i> polysaccharide extract (α-amylase IC<sub>50</sub> 168.06 ± 10.53 µg/mL vs. acarbose 185.67 ± 12.48 µg/mL). Proximate analysis also revealed that all three seaweeds were a good source of protein, fibre, and polyunsaturated essential fatty acids (PUFAs). These findings highlight the potential of these seaweeds in the management of diseases associated with MS and as foods.https://www.mdpi.com/2304-8158/14/2/284seaweednutraceuticalsfunctional foodsmetabolic syndromepolysaccharidespolyphenols |
| spellingShingle | Emer Shannon Maria Hayes <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome Foods seaweed nutraceuticals functional foods metabolic syndrome polysaccharides polyphenols |
| title | <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome |
| title_full | <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome |
| title_fullStr | <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome |
| title_full_unstemmed | <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome |
| title_short | <i>Alaria esculenta, Ulva lactuca</i>, and <i>Palmaria palmata</i> as Potential Functional Food Ingredients for the Management of Metabolic Syndrome |
| title_sort | i alaria esculenta ulva lactuca i and i palmaria palmata i as potential functional food ingredients for the management of metabolic syndrome |
| topic | seaweed nutraceuticals functional foods metabolic syndrome polysaccharides polyphenols |
| url | https://www.mdpi.com/2304-8158/14/2/284 |
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