Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak
Background The aim of this study was to investigate the impact of diabetes on mortality and adverse outcomes in COVID-19 patients and to analyse the associated risk factors. Methods This is a retrospective cohort study in 500 hospitalized patients with COVID-19 infection (214 with diabetes and 286 w...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2025-01-01
|
| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/18865.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582510741028864 |
|---|---|
| author | Yu Li Guanni Li Jiahong Li Zirui Luo Yaxuan Lin Ning Lan Xiaodan Zhang |
| author_facet | Yu Li Guanni Li Jiahong Li Zirui Luo Yaxuan Lin Ning Lan Xiaodan Zhang |
| author_sort | Yu Li |
| collection | DOAJ |
| description | Background The aim of this study was to investigate the impact of diabetes on mortality and adverse outcomes in COVID-19 patients and to analyse the associated risk factors. Methods This is a retrospective cohort study in 500 hospitalized patients with COVID-19 infection (214 with diabetes and 286 without diabetes) admitted to a tertiary hospital in China from December 2022 to February 2023. Demographic information, clinical characteristics and outcomes were collected. Survival status was investigated at discharge and at 6 months after discharge. Results The mortality rate of COVID-19 patients with diabetes was higher than the rate of non-diabetic COVID-19 patients, both at discharge, and at 6 months after discharge. Body mass index (BMI), C-reactive protein (CRP), pH, D-dimer, blood osmotic pressure, serum creatinine, white blood cell count, creatine kinase and hospitalization expenses were significantly different between diabetic group and non-diabetic group (p < 0.05). Compared with the survivors, non-survived COVID-19 patients with diabetes had worse diabetes control indicators, with random blood glucose increased by 3.58 mmol/L (p < 0.05), and fasting blood glucose increased by 2.77 mmol/L (p < 0.01). In addition, there were significant differences in age, heart rate, CRP, pH, potassium (K+), serum creatinine, white blood cell count, creatine kinase, the proportion with diabetic complications, treatment in ICU and mechanical ventilation between survivors and non-survivors of COVID-19 patients with diabetes. By multivariate logistic regression analysis, the death of COVID-19 patients with diabetes is positively correlated with age and CRP (p < 0.05), and has a trend towards significance with fasting blood glucose (p < 0.1). Conclusion Infection with COVID-19 on the basis of diabetes can significantly increase mortality, which was further associated with diabetes control indicators. |
| format | Article |
| id | doaj-art-57b85d22df5447eb8489ce9706c5b192 |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-57b85d22df5447eb8489ce9706c5b1922025-01-29T15:05:13ZengPeerJ Inc.PeerJ2167-83592025-01-0113e1886510.7717/peerj.18865Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreakYu Li0Guanni Li1Jiahong Li2Zirui Luo3Yaxuan Lin4Ning Lan5Xiaodan Zhang6Department of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaThe Second Clinical Medicine School, Guangzhou Medical University, Guangzhou, ChinaThe Second Clinical Medicine School, Guangzhou Medical University, Guangzhou, ChinaThe Second Clinical Medicine School, Guangzhou Medical University, Guangzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaBackground The aim of this study was to investigate the impact of diabetes on mortality and adverse outcomes in COVID-19 patients and to analyse the associated risk factors. Methods This is a retrospective cohort study in 500 hospitalized patients with COVID-19 infection (214 with diabetes and 286 without diabetes) admitted to a tertiary hospital in China from December 2022 to February 2023. Demographic information, clinical characteristics and outcomes were collected. Survival status was investigated at discharge and at 6 months after discharge. Results The mortality rate of COVID-19 patients with diabetes was higher than the rate of non-diabetic COVID-19 patients, both at discharge, and at 6 months after discharge. Body mass index (BMI), C-reactive protein (CRP), pH, D-dimer, blood osmotic pressure, serum creatinine, white blood cell count, creatine kinase and hospitalization expenses were significantly different between diabetic group and non-diabetic group (p < 0.05). Compared with the survivors, non-survived COVID-19 patients with diabetes had worse diabetes control indicators, with random blood glucose increased by 3.58 mmol/L (p < 0.05), and fasting blood glucose increased by 2.77 mmol/L (p < 0.01). In addition, there were significant differences in age, heart rate, CRP, pH, potassium (K+), serum creatinine, white blood cell count, creatine kinase, the proportion with diabetic complications, treatment in ICU and mechanical ventilation between survivors and non-survivors of COVID-19 patients with diabetes. By multivariate logistic regression analysis, the death of COVID-19 patients with diabetes is positively correlated with age and CRP (p < 0.05), and has a trend towards significance with fasting blood glucose (p < 0.1). Conclusion Infection with COVID-19 on the basis of diabetes can significantly increase mortality, which was further associated with diabetes control indicators.https://peerj.com/articles/18865.pdfDiabetesCOVID-19Diabetic complicationsMortalityRisk factors |
| spellingShingle | Yu Li Guanni Li Jiahong Li Zirui Luo Yaxuan Lin Ning Lan Xiaodan Zhang Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak PeerJ Diabetes COVID-19 Diabetic complications Mortality Risk factors |
| title | Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak |
| title_full | Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak |
| title_fullStr | Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak |
| title_full_unstemmed | Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak |
| title_short | Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak |
| title_sort | correlation of diabetes and adverse outcomes in hospitalized covid 19 patients admitted to a tertiary hospital in china during a small scale covid 19 outbreak |
| topic | Diabetes COVID-19 Diabetic complications Mortality Risk factors |
| url | https://peerj.com/articles/18865.pdf |
| work_keys_str_mv | AT yuli correlationofdiabetesandadverseoutcomesinhospitalizedcovid19patientsadmittedtoatertiaryhospitalinchinaduringasmallscalecovid19outbreak AT guannili correlationofdiabetesandadverseoutcomesinhospitalizedcovid19patientsadmittedtoatertiaryhospitalinchinaduringasmallscalecovid19outbreak AT jiahongli correlationofdiabetesandadverseoutcomesinhospitalizedcovid19patientsadmittedtoatertiaryhospitalinchinaduringasmallscalecovid19outbreak AT ziruiluo correlationofdiabetesandadverseoutcomesinhospitalizedcovid19patientsadmittedtoatertiaryhospitalinchinaduringasmallscalecovid19outbreak AT yaxuanlin correlationofdiabetesandadverseoutcomesinhospitalizedcovid19patientsadmittedtoatertiaryhospitalinchinaduringasmallscalecovid19outbreak AT ninglan correlationofdiabetesandadverseoutcomesinhospitalizedcovid19patientsadmittedtoatertiaryhospitalinchinaduringasmallscalecovid19outbreak AT xiaodanzhang correlationofdiabetesandadverseoutcomesinhospitalizedcovid19patientsadmittedtoatertiaryhospitalinchinaduringasmallscalecovid19outbreak |