Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients
Abstract FGF21 regulates local and systemic metabolic homeostasis. High serum FGF21 was found in obesity, metabolic syndrome, type 2 diabetes mellitus, and coronary heart disease. The pathways linking obesity and breast cancer remain elusive. We aimed to analyze the serum FGF21 in breast cancer pati...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-024-02003-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585493396586496 |
|---|---|
| author | Stella Maris Ranuncolo Eduardo Armanasco Myriam Nuñez Laura Yuan Sujhrob Makhkamov Mariana S. De Lorenzo |
| author_facet | Stella Maris Ranuncolo Eduardo Armanasco Myriam Nuñez Laura Yuan Sujhrob Makhkamov Mariana S. De Lorenzo |
| author_sort | Stella Maris Ranuncolo |
| collection | DOAJ |
| description | Abstract FGF21 regulates local and systemic metabolic homeostasis. High serum FGF21 was found in obesity, metabolic syndrome, type 2 diabetes mellitus, and coronary heart disease. The pathways linking obesity and breast cancer remain elusive. We aimed to analyze the serum FGF21 in breast cancer patients at diagnosis. Circulating FGF21 levels in 45 breast cancer women (median age 59, range 32–88 years) and 51 age-matched healthy controls were evaluated using a quantitative ELISA assay. Patients’ samples were obtained before surgery ahead of any previous therapy. Breast cancer patients showed significantly elevated serum FGF21 (median 267.13, range 28.41-780.45) respect to healthy controls (76.86, 0.00-425.60) (p < 0.0001). A ROC curve determined a cut-off value of 130.64 pg/ml to define positive or high FGF21 levels. Based on this cut-off point, 30/45 (66.7%) breast cancer patients showed positive serum FGF21 levels as compared to 18/51 (35.3%) healthy controls. Circulating FGF21 levels could be useful as a highly sensitive diagnosis biomarker for early breast cancer detection. We did not find any significant association between the serum FGF21 levels, and many clinical-pathological or metabolic parameters determined at the diagnosis of the primary disease. Interestingly, a statistically significant correlation was determined between serum FGF21 and the body mass index (BMI). Furthermore, patients with positive FGF21 serum levels had a worst overall survival (Log Rank Test [Mantle Cox] p = 0.017). We propose serum FGF21 levels determined at the diagnosis of primary breast cancer as a promising diagnostic and prognosis biomarker in this oncological disease. |
| format | Article |
| id | doaj-art-57b2ed13873b44e38e135347b0292d57 |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-57b2ed13873b44e38e135347b0292d572025-01-26T12:44:45ZengBMCCell Communication and Signaling1478-811X2025-01-012311910.1186/s12964-024-02003-zRole of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patientsStella Maris Ranuncolo0Eduardo Armanasco1Myriam Nuñez2Laura Yuan3Sujhrob Makhkamov4Mariana S. De Lorenzo5Instituto de Oncología “Ángel H. Roffo” Facultad de Medicina, Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Breast Cancer Department, Instituto de Oncología “Ángel H. Roffo” Facultad de Medicina, Universidad de Buenos Aires (UBA)Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires (UBA)Laboratory of Metabolism and Cancer Prevention, Department of Cell Biology & Molecular Medicine, Rutgers New Jersey Medical SchoolLaboratory of Metabolism and Cancer Prevention, Department of Cell Biology & Molecular Medicine, Rutgers New Jersey Medical SchoolLaboratory of Metabolism and Cancer Prevention, Department of Cell Biology & Molecular Medicine, Rutgers New Jersey Medical SchoolAbstract FGF21 regulates local and systemic metabolic homeostasis. High serum FGF21 was found in obesity, metabolic syndrome, type 2 diabetes mellitus, and coronary heart disease. The pathways linking obesity and breast cancer remain elusive. We aimed to analyze the serum FGF21 in breast cancer patients at diagnosis. Circulating FGF21 levels in 45 breast cancer women (median age 59, range 32–88 years) and 51 age-matched healthy controls were evaluated using a quantitative ELISA assay. Patients’ samples were obtained before surgery ahead of any previous therapy. Breast cancer patients showed significantly elevated serum FGF21 (median 267.13, range 28.41-780.45) respect to healthy controls (76.86, 0.00-425.60) (p < 0.0001). A ROC curve determined a cut-off value of 130.64 pg/ml to define positive or high FGF21 levels. Based on this cut-off point, 30/45 (66.7%) breast cancer patients showed positive serum FGF21 levels as compared to 18/51 (35.3%) healthy controls. Circulating FGF21 levels could be useful as a highly sensitive diagnosis biomarker for early breast cancer detection. We did not find any significant association between the serum FGF21 levels, and many clinical-pathological or metabolic parameters determined at the diagnosis of the primary disease. Interestingly, a statistically significant correlation was determined between serum FGF21 and the body mass index (BMI). Furthermore, patients with positive FGF21 serum levels had a worst overall survival (Log Rank Test [Mantle Cox] p = 0.017). We propose serum FGF21 levels determined at the diagnosis of primary breast cancer as a promising diagnostic and prognosis biomarker in this oncological disease.https://doi.org/10.1186/s12964-024-02003-zSerum fibroblast growth factor 21Breast CancerObesityMetabolic syndromeDiagnosis biomarkerPrognosis Biomarker. |
| spellingShingle | Stella Maris Ranuncolo Eduardo Armanasco Myriam Nuñez Laura Yuan Sujhrob Makhkamov Mariana S. De Lorenzo Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients Cell Communication and Signaling Serum fibroblast growth factor 21 Breast Cancer Obesity Metabolic syndrome Diagnosis biomarker Prognosis Biomarker. |
| title | Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients |
| title_full | Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients |
| title_fullStr | Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients |
| title_full_unstemmed | Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients |
| title_short | Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients |
| title_sort | role of the serum levels of the inter organs messenger fibroblast growth factor 21 fgf21 in the diagnosis and prognosis of breast cancer patients |
| topic | Serum fibroblast growth factor 21 Breast Cancer Obesity Metabolic syndrome Diagnosis biomarker Prognosis Biomarker. |
| url | https://doi.org/10.1186/s12964-024-02003-z |
| work_keys_str_mv | AT stellamarisranuncolo roleoftheserumlevelsoftheinterorgansmessengerfibroblastgrowthfactor21fgf21inthediagnosisandprognosisofbreastcancerpatients AT eduardoarmanasco roleoftheserumlevelsoftheinterorgansmessengerfibroblastgrowthfactor21fgf21inthediagnosisandprognosisofbreastcancerpatients AT myriamnunez roleoftheserumlevelsoftheinterorgansmessengerfibroblastgrowthfactor21fgf21inthediagnosisandprognosisofbreastcancerpatients AT laurayuan roleoftheserumlevelsoftheinterorgansmessengerfibroblastgrowthfactor21fgf21inthediagnosisandprognosisofbreastcancerpatients AT sujhrobmakhkamov roleoftheserumlevelsoftheinterorgansmessengerfibroblastgrowthfactor21fgf21inthediagnosisandprognosisofbreastcancerpatients AT marianasdelorenzo roleoftheserumlevelsoftheinterorgansmessengerfibroblastgrowthfactor21fgf21inthediagnosisandprognosisofbreastcancerpatients |