Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis

Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis

Abstract Sepsis is a leading cause of death worldwide, with most patient mortality stemming from lingering immunosuppression in sepsis survivors. This is due in part to immune dysfunction resulting from monocyte exhaustion, a phenotype of reduced antigen presentation, altered CD14/CD16 inflammatory...

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Bibliographic Details
Main Authors: Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Ticam2
Sepsis
Monocyte exhaustion
Innate immune memory
Online Access:https://doi.org/10.1038/s41598-025-86103-x
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