Limb Regeneration in Amphibians: Immunological Considerations
We review key aspects of what is known about limb regeneration in urodele and anuran amphibians, with a focus on the early events of the process that lead to formation of the regeneration blastema. This includes the role of the nerves and wound epithelium, but also covers the inflammatory effects of...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.323 |
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| _version_ | 1832551733632434176 |
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| author | Anthony L. Mescher Anton W. Neff |
| author_facet | Anthony L. Mescher Anton W. Neff |
| author_sort | Anthony L. Mescher |
| collection | DOAJ |
| description | We review key aspects of what is known about limb regeneration in urodele and anuran amphibians, with a focus on the early events of the process that lead to formation of the regeneration blastema. This includes the role of the nerves and wound epithelium, but also covers the inflammatory effects of the amputation trauma and their importance for regenerative growth. We propose that immunotolerance is important for limb regeneration and changes in its regulation may underlie the loss of regenerative capacity during anuran metamorphosis. |
| format | Article |
| id | doaj-art-57a7c5973fea4d798e42e8e7e8f485fc |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-57a7c5973fea4d798e42e8e7e8f485fc2025-02-03T06:00:39ZengWileyThe Scientific World Journal1537-744X2006-01-01611110.1100/tsw.2006.323Limb Regeneration in Amphibians: Immunological ConsiderationsAnthony L. Mescher0Anton W. Neff1Indiana University School of Medicine-Bloomington, Indiana University Center for Regenerative Biology and Medicine, Bloomington, IN 47405, USAIndiana University School of Medicine-Bloomington, Indiana University Center for Regenerative Biology and Medicine, Bloomington, IN 47405, USAWe review key aspects of what is known about limb regeneration in urodele and anuran amphibians, with a focus on the early events of the process that lead to formation of the regeneration blastema. This includes the role of the nerves and wound epithelium, but also covers the inflammatory effects of the amputation trauma and their importance for regenerative growth. We propose that immunotolerance is important for limb regeneration and changes in its regulation may underlie the loss of regenerative capacity during anuran metamorphosis.http://dx.doi.org/10.1100/tsw.2006.323 |
| spellingShingle | Anthony L. Mescher Anton W. Neff Limb Regeneration in Amphibians: Immunological Considerations The Scientific World Journal |
| title | Limb Regeneration in Amphibians: Immunological Considerations |
| title_full | Limb Regeneration in Amphibians: Immunological Considerations |
| title_fullStr | Limb Regeneration in Amphibians: Immunological Considerations |
| title_full_unstemmed | Limb Regeneration in Amphibians: Immunological Considerations |
| title_short | Limb Regeneration in Amphibians: Immunological Considerations |
| title_sort | limb regeneration in amphibians immunological considerations |
| url | http://dx.doi.org/10.1100/tsw.2006.323 |
| work_keys_str_mv | AT anthonylmescher limbregenerationinamphibiansimmunologicalconsiderations AT antonwneff limbregenerationinamphibiansimmunologicalconsiderations |