Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells

Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells

Abstract Background Melanoma is one of the most commonly diagnosed malignancies and serves as a model for studying immunotherapy. The B16 melanoma model, resembling human cold tumors that lack T cell infiltration and show minimal response to PD-1 blockade, is widely used for studying melanoma and it...

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Main Authors: Rong Huang, Yingbin Wang, Haitao Teng, Mengjun Xu, Kexin He, Yingzhuo Shen, Guo Guo, Xinyu Feng, Tianhan Li, Binhui Zhou, Marc Bajenoff, Toby Lawrence, Yinming Liang, Liaoxun Lu, Lichen Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Biology
Subjects:
Melanoma
Tyrosinase
Tumor infiltrating T cells
PD-1
Online Access:https://doi.org/10.1186/s12915-025-02237-4
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https://doi.org/10.1186/s12915-025-02237-4

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