General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form
In an attempt to model occupational and environmental Mn exposures and their possible interaction, young male Wistar rats were exposed to Mn by oral administration in dissolved form (MnCl2·4H2O, 14.84 and 59.36 mg/kg b.w.) and by intratracheal application of MnO2 nanoparticles (2.63 mg/kg b.w.). Aft...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/520632 |
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| author | Edina Horváth Zsuzsanna Máté Szabolcs Takács Péter Pusztai András Sápi Zoltán Kónya László Nagymajtényi András Papp |
| author_facet | Edina Horváth Zsuzsanna Máté Szabolcs Takács Péter Pusztai András Sápi Zoltán Kónya László Nagymajtényi András Papp |
| author_sort | Edina Horváth |
| collection | DOAJ |
| description | In an attempt to model occupational and environmental Mn exposures and their possible interaction, young male Wistar rats were exposed to Mn by oral administration in dissolved form (MnCl2·4H2O, 14.84 and 59.36 mg/kg b.w.) and by intratracheal application of MnO2 nanoparticles (2.63 mg/kg b.w.). After 3 and 6 weeks oral, or 3 weeks oral plus 3 weeks intratracheal, exposure, general toxicological, and electrophysiological tests were done. Body weight gain was significantly reduced after 6 and 3 plus 3 weeks exposure, but the effect of the latter on the pace of weight gain was stronger. Organ weights signalized systemic stress and effect on lungs. Changes in evoked electrophysiological responses (cortical sensory evoked potential and nerve action potential) indicated that the 3 plus 3 weeks combined exposure caused equal or higher changes in the latency of these responses than 6 weeks of exposure, although the calculated summed Mn dose in the former case was lower. The results showed the importance of the physicochemical form of Mn in determining the toxic outcome, and suggested that neurofunctional markers of Mn action may indicate the human health effect better than conventional blood Mn measurement. |
| format | Article |
| id | doaj-art-57966c313a5440fda3fd226286cb1cac |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-57966c313a5440fda3fd226286cb1cac2025-02-03T06:06:18ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/520632520632General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle FormEdina Horváth0Zsuzsanna Máté1Szabolcs Takács2Péter Pusztai3András Sápi4Zoltán Kónya5László Nagymajtényi6András Papp7Department of Public Health, University of Szeged Faculty of Medicine, Dóm tér 10., 6720 Szeged, HungaryDepartment of Public Health, University of Szeged Faculty of Medicine, Dóm tér 10., 6720 Szeged, HungaryDepartment of Public Health, University of Szeged Faculty of Medicine, Dóm tér 10., 6720 Szeged, HungaryDepartment of Applied Chemistry, University of Szeged Faculty of Science and Informatics, Rerrich Béla tér 1., 6720 Szeged, HungaryDepartment of Applied Chemistry, University of Szeged Faculty of Science and Informatics, Rerrich Béla tér 1., 6720 Szeged, HungaryDepartment of Applied Chemistry, University of Szeged Faculty of Science and Informatics, Rerrich Béla tér 1., 6720 Szeged, HungaryDepartment of Public Health, University of Szeged Faculty of Medicine, Dóm tér 10., 6720 Szeged, HungaryDepartment of Public Health, University of Szeged Faculty of Medicine, Dóm tér 10., 6720 Szeged, HungaryIn an attempt to model occupational and environmental Mn exposures and their possible interaction, young male Wistar rats were exposed to Mn by oral administration in dissolved form (MnCl2·4H2O, 14.84 and 59.36 mg/kg b.w.) and by intratracheal application of MnO2 nanoparticles (2.63 mg/kg b.w.). After 3 and 6 weeks oral, or 3 weeks oral plus 3 weeks intratracheal, exposure, general toxicological, and electrophysiological tests were done. Body weight gain was significantly reduced after 6 and 3 plus 3 weeks exposure, but the effect of the latter on the pace of weight gain was stronger. Organ weights signalized systemic stress and effect on lungs. Changes in evoked electrophysiological responses (cortical sensory evoked potential and nerve action potential) indicated that the 3 plus 3 weeks combined exposure caused equal or higher changes in the latency of these responses than 6 weeks of exposure, although the calculated summed Mn dose in the former case was lower. The results showed the importance of the physicochemical form of Mn in determining the toxic outcome, and suggested that neurofunctional markers of Mn action may indicate the human health effect better than conventional blood Mn measurement.http://dx.doi.org/10.1100/2012/520632 |
| spellingShingle | Edina Horváth Zsuzsanna Máté Szabolcs Takács Péter Pusztai András Sápi Zoltán Kónya László Nagymajtényi András Papp General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form The Scientific World Journal |
| title | General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form |
| title_full | General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form |
| title_fullStr | General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form |
| title_full_unstemmed | General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form |
| title_short | General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form |
| title_sort | general and electrophysiological toxic effects of manganese in rats following subacute administration in dissolved and nanoparticle form |
| url | http://dx.doi.org/10.1100/2012/520632 |
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