First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin
Aim. To assess the efficacy of 7-day first-line Helicobacter pylori eradication with vonoprazan (VPZ), clarithromycin (CAM), and metronidazole (MNZ) in patients with penicillin allergy. Methods. Patients with penicillin allergy, diagnosed with Helicobacter pylori infection and did not have history o...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/2019802 |
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| author | Soichiro Sue Nobumi Suzuki Wataru Shibata Tomohiko Sasaki Hiroaki Yamada Hiroaki Kaneko Toshihide Tamura Tomohiro Ishii Masaaki Kondo Shin Maeda |
| author_facet | Soichiro Sue Nobumi Suzuki Wataru Shibata Tomohiko Sasaki Hiroaki Yamada Hiroaki Kaneko Toshihide Tamura Tomohiro Ishii Masaaki Kondo Shin Maeda |
| author_sort | Soichiro Sue |
| collection | DOAJ |
| description | Aim. To assess the efficacy of 7-day first-line Helicobacter pylori eradication with vonoprazan (VPZ), clarithromycin (CAM), and metronidazole (MNZ) in patients with penicillin allergy. Methods. Patients with penicillin allergy, diagnosed with Helicobacter pylori infection and did not have history of Helicobacter pylori eradication, were eligible for the study. Twenty patients were prospectively treated with 20 mg VPZ twice daily, 200 or 400 mg CAM twice daily, and 250 mg MNZ twice daily for 7 days. We also collected the data from 30 patients retrospectively treated with proton pump inhibitor (PPI), CAM, and MNZ. Safety was evaluated in patients completing an adverse effect questionnaire. Results. Both the intention-to-treat and per-protocol effectiveness of VPZ-based eradication were 100% (95% CI: 86.1–100%; n=20). The eradication rates of PPI-based regimen were 83.3% (95% CI: 65.3–94.4%) in the ITT and 82.7% (95% CI: 64.2–94.2%) in the PP analyses. Abdominal fullness was more frequent in VCM compared to PCM. However, all patients with VCM regimen had taken 100% of their course of medication. Conclusion. Triple therapy with VPZ, CAM, and MNZ is well tolerated and effective for eradicating Helicobacter pylori in patients allergic to penicillin. This study was registered in the UMIN Clinical Trials Registry as UMIN000016335. |
| format | Article |
| id | doaj-art-578e3a2c4c184e96bfcca454481dc8c1 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-578e3a2c4c184e96bfcca454481dc8c12025-02-03T01:09:13ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/20198022019802First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to PenicillinSoichiro Sue0Nobumi Suzuki1Wataru Shibata2Tomohiko Sasaki3Hiroaki Yamada4Hiroaki Kaneko5Toshihide Tamura6Tomohiro Ishii7Masaaki Kondo8Shin Maeda9Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, JapanDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanAim. To assess the efficacy of 7-day first-line Helicobacter pylori eradication with vonoprazan (VPZ), clarithromycin (CAM), and metronidazole (MNZ) in patients with penicillin allergy. Methods. Patients with penicillin allergy, diagnosed with Helicobacter pylori infection and did not have history of Helicobacter pylori eradication, were eligible for the study. Twenty patients were prospectively treated with 20 mg VPZ twice daily, 200 or 400 mg CAM twice daily, and 250 mg MNZ twice daily for 7 days. We also collected the data from 30 patients retrospectively treated with proton pump inhibitor (PPI), CAM, and MNZ. Safety was evaluated in patients completing an adverse effect questionnaire. Results. Both the intention-to-treat and per-protocol effectiveness of VPZ-based eradication were 100% (95% CI: 86.1–100%; n=20). The eradication rates of PPI-based regimen were 83.3% (95% CI: 65.3–94.4%) in the ITT and 82.7% (95% CI: 64.2–94.2%) in the PP analyses. Abdominal fullness was more frequent in VCM compared to PCM. However, all patients with VCM regimen had taken 100% of their course of medication. Conclusion. Triple therapy with VPZ, CAM, and MNZ is well tolerated and effective for eradicating Helicobacter pylori in patients allergic to penicillin. This study was registered in the UMIN Clinical Trials Registry as UMIN000016335.http://dx.doi.org/10.1155/2017/2019802 |
| spellingShingle | Soichiro Sue Nobumi Suzuki Wataru Shibata Tomohiko Sasaki Hiroaki Yamada Hiroaki Kaneko Toshihide Tamura Tomohiro Ishii Masaaki Kondo Shin Maeda First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin Gastroenterology Research and Practice |
| title | First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin |
| title_full | First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin |
| title_fullStr | First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin |
| title_full_unstemmed | First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin |
| title_short | First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin |
| title_sort | first line helicobacter pylori eradication with vonoprazan clarithromycin and metronidazole in patients allergic to penicillin |
| url | http://dx.doi.org/10.1155/2017/2019802 |
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