Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition
Abstract The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intr...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-024-01634-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594479521988608 |
|---|---|
| author | Antonino Glaviano Hannah Si-Hui Lau Lukas M. Carter E. Hui Clarissa Lee Hiu Yan Lam Elena Okina Donavan Jia Jie Tan Wency Tan Hui Li Ang Daniela Carbone Michelle Yi-Hui Yee Muthu K. Shanmugam Xiao Zi Huang Gautam Sethi Tuan Zea Tan Lina H. K. Lim Ruby Yun-Ju Huang Hendrik Ungefroren Elisa Giovannetti Dean G. Tang Tullia C. Bruno Peng Luo Mads Hald Andersen Bin-Zhi Qian Jun Ishihara Derek C. Radisky Salem Elias Saurabh Yadav Minah Kim Caroline Robert Patrizia Diana Kurt A. Schalper Tao Shi Taha Merghoub Simone Krebs Anjali P. Kusumbe Matthew S. Davids Jennifer R. Brown Alan Prem Kumar |
| author_facet | Antonino Glaviano Hannah Si-Hui Lau Lukas M. Carter E. Hui Clarissa Lee Hiu Yan Lam Elena Okina Donavan Jia Jie Tan Wency Tan Hui Li Ang Daniela Carbone Michelle Yi-Hui Yee Muthu K. Shanmugam Xiao Zi Huang Gautam Sethi Tuan Zea Tan Lina H. K. Lim Ruby Yun-Ju Huang Hendrik Ungefroren Elisa Giovannetti Dean G. Tang Tullia C. Bruno Peng Luo Mads Hald Andersen Bin-Zhi Qian Jun Ishihara Derek C. Radisky Salem Elias Saurabh Yadav Minah Kim Caroline Robert Patrizia Diana Kurt A. Schalper Tao Shi Taha Merghoub Simone Krebs Anjali P. Kusumbe Matthew S. Davids Jennifer R. Brown Alan Prem Kumar |
| author_sort | Antonino Glaviano |
| collection | DOAJ |
| description | Abstract The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges. A critical process induced by TME signaling is the epithelial-mesenchymal transition (EMT), wherein epithelial cells acquire mesenchymal traits, which enhance their motility and invasiveness and promote metastasis and cancer progression. By targeting various components of the TME, novel investigational strategies aim to disrupt the TME’s contribution to the EMT, thereby improving treatment efficacy, addressing therapeutic resistance, and offering a nuanced approach to cancer therapy. This review scrutinizes the key players in the TME and the TME's contribution to the EMT, emphasizing avenues to therapeutically disrupt the interactions between the various TME components. Moreover, the article discusses the TME’s implications for resistance mechanisms and highlights the current therapeutic strategies toward TME modulation along with potential caveats. |
| format | Article |
| id | doaj-art-5786638e01cd4b2ca552206d4b82bf17 |
| institution | Kabale University |
| issn | 1756-8722 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj-art-5786638e01cd4b2ca552206d4b82bf172025-01-19T12:36:22ZengBMCJournal of Hematology & Oncology1756-87222025-01-0118119610.1186/s13045-024-01634-6Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transitionAntonino Glaviano0Hannah Si-Hui Lau1Lukas M. Carter2E. Hui Clarissa Lee3Hiu Yan Lam4Elena Okina5Donavan Jia Jie Tan6Wency Tan7Hui Li Ang8Daniela Carbone9Michelle Yi-Hui Yee10Muthu K. Shanmugam11Xiao Zi Huang12Gautam Sethi13Tuan Zea Tan14Lina H. K. Lim15Ruby Yun-Ju Huang16Hendrik Ungefroren17Elisa Giovannetti18Dean G. Tang19Tullia C. Bruno20Peng Luo21Mads Hald Andersen22Bin-Zhi Qian23Jun Ishihara24Derek C. Radisky25Salem Elias26Saurabh Yadav27Minah Kim28Caroline Robert29Patrizia Diana30Kurt A. Schalper31Tao Shi32Taha Merghoub33Simone Krebs34Anjali P. Kusumbe35Matthew S. Davids36Jennifer R. Brown37Alan Prem Kumar38Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of PalermoDivision of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre SingaporeDepartment of Medical Physics, Memorial Sloan Kettering Cancer CenterDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of PalermoDivision of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeDivision of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre SingaporeSchool of Medicine and Graduate Institute of Oncology, College of Medicine, National Taiwan UniversityFirst Department of Medicine, University Hospital Schleswig-Holstein (UKSH)Department of Medical Oncology, Cancer Center Amsterdam, UMC, Vrije Universiteit, HV AmsterdamDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer CenterDepartment of Immunology, School of Medicine, University of PittsburghDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityNational Center for Cancer Immune Therapy, Department of Oncology, Herlev and Gentofte HospitalFudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, The Human Phenome Institute, Zhangjiang-Fudan International Innovation Center, Fudan UniversityDepartment of Bioengineering, Imperial College LondonDepartment of Cancer Biology, Mayo ClinicDana-Farber Cancer Institute, Harvard Medical SchoolDana-Farber Cancer Institute, Harvard Medical SchoolHerbert Irving Comprehensive Cancer Center, Columbia UniversityDepartment of Cancer Medicine, Inserm U981, Gustave Roussy Cancer Center, Université Paris-SaclayDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of PalermoDepartment of Pathology, Yale School of Medicine, Yale UniversitySwim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell MedicineSwim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell MedicineDepartment of Radiology, Memorial Sloan Kettering Cancer CenterTissue and Tumor Microenvironment Group, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of OxfordDana-Farber Cancer Institute, Harvard Medical SchoolDana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of SingaporeAbstract The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges. A critical process induced by TME signaling is the epithelial-mesenchymal transition (EMT), wherein epithelial cells acquire mesenchymal traits, which enhance their motility and invasiveness and promote metastasis and cancer progression. By targeting various components of the TME, novel investigational strategies aim to disrupt the TME’s contribution to the EMT, thereby improving treatment efficacy, addressing therapeutic resistance, and offering a nuanced approach to cancer therapy. This review scrutinizes the key players in the TME and the TME's contribution to the EMT, emphasizing avenues to therapeutically disrupt the interactions between the various TME components. Moreover, the article discusses the TME’s implications for resistance mechanisms and highlights the current therapeutic strategies toward TME modulation along with potential caveats.https://doi.org/10.1186/s13045-024-01634-6CancerTumor microenvironment (TME)T-cells, B-cells, tumor-associated macrophages (TAMs)Natural killer (NK) cellsMyeloid-derived suppressor cells (MDSCs)Tumor-associated neutrophils (TANs) |
| spellingShingle | Antonino Glaviano Hannah Si-Hui Lau Lukas M. Carter E. Hui Clarissa Lee Hiu Yan Lam Elena Okina Donavan Jia Jie Tan Wency Tan Hui Li Ang Daniela Carbone Michelle Yi-Hui Yee Muthu K. Shanmugam Xiao Zi Huang Gautam Sethi Tuan Zea Tan Lina H. K. Lim Ruby Yun-Ju Huang Hendrik Ungefroren Elisa Giovannetti Dean G. Tang Tullia C. Bruno Peng Luo Mads Hald Andersen Bin-Zhi Qian Jun Ishihara Derek C. Radisky Salem Elias Saurabh Yadav Minah Kim Caroline Robert Patrizia Diana Kurt A. Schalper Tao Shi Taha Merghoub Simone Krebs Anjali P. Kusumbe Matthew S. Davids Jennifer R. Brown Alan Prem Kumar Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition Journal of Hematology & Oncology Cancer Tumor microenvironment (TME) T-cells, B-cells, tumor-associated macrophages (TAMs) Natural killer (NK) cells Myeloid-derived suppressor cells (MDSCs) Tumor-associated neutrophils (TANs) |
| title | Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition |
| title_full | Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition |
| title_fullStr | Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition |
| title_full_unstemmed | Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition |
| title_short | Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition |
| title_sort | harnessing the tumor microenvironment targeted cancer therapies through modulation of epithelial mesenchymal transition |
| topic | Cancer Tumor microenvironment (TME) T-cells, B-cells, tumor-associated macrophages (TAMs) Natural killer (NK) cells Myeloid-derived suppressor cells (MDSCs) Tumor-associated neutrophils (TANs) |
| url | https://doi.org/10.1186/s13045-024-01634-6 |
| work_keys_str_mv | AT antoninoglaviano harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT hannahsihuilau harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT lukasmcarter harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT ehuiclarissalee harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT hiuyanlam harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT elenaokina harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT donavanjiajietan harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT wencytan harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT huiliang harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT danielacarbone harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT michelleyihuiyee harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT muthukshanmugam harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT xiaozihuang harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT gautamsethi harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT tuanzeatan harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT linahklim harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT rubyyunjuhuang harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT hendrikungefroren harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT elisagiovannetti harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT deangtang harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT tulliacbruno harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT pengluo harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT madshaldandersen harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT binzhiqian harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT junishihara harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT derekcradisky harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT salemelias harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT saurabhyadav harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT minahkim harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT carolinerobert harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT patriziadiana harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT kurtaschalper harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT taoshi harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT tahamerghoub harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT simonekrebs harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT anjalipkusumbe harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT matthewsdavids harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT jenniferrbrown harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition AT alanpremkumar harnessingthetumormicroenvironmenttargetedcancertherapiesthroughmodulationofepithelialmesenchymaltransition |