Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest
Reaction of 2-(aminomethyl)benzimidazole dihydrochloride (1) with ethyl acetoacetate was studied to give diazepinone-benzimidazole derivative (2), while, treatment of 1 with phenylhydrazono ethylacetoacetate afforded phenylhydrazino diazepinone derivative (3). On the other hand, reaction of 1 with a...
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/723421 |
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| author | Fawzia Zakaria El-Ablack |
| author_facet | Fawzia Zakaria El-Ablack |
| author_sort | Fawzia Zakaria El-Ablack |
| collection | DOAJ |
| description | Reaction of 2-(aminomethyl)benzimidazole dihydrochloride (1) with ethyl acetoacetate was studied to give diazepinone-benzimidazole derivative (2), while, treatment of 1 with phenylhydrazono ethylacetoacetate afforded phenylhydrazino diazepinone derivative (3). On the other hand, reaction of 1 with acetyl acetone resulted in the formation of diazepine derivative (4). The reaction of 1 with ethyl cyanoacetate was studied to give 3-aminodiazepinone derivative (5). Also the reaction of 1 with acetophenone and/or benzophenone has been investigated to give the fused imidazolines 6 and 7 respectively, while the reaction of 1 with cyclopentanone gave benzimidazolyl derivative (8). Treatment of 1 with chloroacetyl chloride gave the fused pyrazinone (9). The treatment of 1 with benzoin gave the derivative (10). The structures of the hitherto unknown compounds have been confirmed from analytical and spectral data. The newly synthesized compounds were screened for antibacterial and antifungal activity. |
| format | Article |
| id | doaj-art-577f82813a0447238af0b1a9619728cc |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-577f82813a0447238af0b1a9619728cc2025-02-03T06:42:19ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018274875210.1155/2011/723421Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical InterestFawzia Zakaria El-Ablack0Chemistry Department, Damietta Faculty of Science , Mansoura University, EgyptReaction of 2-(aminomethyl)benzimidazole dihydrochloride (1) with ethyl acetoacetate was studied to give diazepinone-benzimidazole derivative (2), while, treatment of 1 with phenylhydrazono ethylacetoacetate afforded phenylhydrazino diazepinone derivative (3). On the other hand, reaction of 1 with acetyl acetone resulted in the formation of diazepine derivative (4). The reaction of 1 with ethyl cyanoacetate was studied to give 3-aminodiazepinone derivative (5). Also the reaction of 1 with acetophenone and/or benzophenone has been investigated to give the fused imidazolines 6 and 7 respectively, while the reaction of 1 with cyclopentanone gave benzimidazolyl derivative (8). Treatment of 1 with chloroacetyl chloride gave the fused pyrazinone (9). The treatment of 1 with benzoin gave the derivative (10). The structures of the hitherto unknown compounds have been confirmed from analytical and spectral data. The newly synthesized compounds were screened for antibacterial and antifungal activity.http://dx.doi.org/10.1155/2011/723421 |
| spellingShingle | Fawzia Zakaria El-Ablack Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest E-Journal of Chemistry |
| title | Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest |
| title_full | Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest |
| title_fullStr | Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest |
| title_full_unstemmed | Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest |
| title_short | Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest |
| title_sort | synthesis of some new benzimidazole derivatives of pharmaceutical interest |
| url | http://dx.doi.org/10.1155/2011/723421 |
| work_keys_str_mv | AT fawziazakariaelablack synthesisofsomenewbenzimidazolederivativesofpharmaceuticalinterest |