Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia
Objective. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission. Predictive value of th...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1583951 |
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| author | Jia Sun Junwei Su Yirui Xie Michael T. Yin Ying Huang Lijun Xu Qihui Zhou Biao Zhu |
| author_facet | Jia Sun Junwei Su Yirui Xie Michael T. Yin Ying Huang Lijun Xu Qihui Zhou Biao Zhu |
| author_sort | Jia Sun |
| collection | DOAJ |
| description | Objective. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve. Results. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (P=0.008, R2=0.258), HBDH (P=0.001, R2=0.335), and Ferritin (P=0.005, R2=0.237). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 ≤ 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, P<0.001; 1.11 ± 0.72, P=0.043), larger AUC (95% CI 0.781–1.000, P<0.001; 95% CI 0.592–0.917, P=0.043), and more significantly inverse correlation with the oxygenation index. Conclusion. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients. |
| format | Article |
| id | doaj-art-577ca23eae754a42a18a2aa2456f60fc |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-577ca23eae754a42a18a2aa2456f60fc2025-02-03T06:42:19ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/15839511583951Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis PneumoniaJia Sun0Junwei Su1Yirui Xie2Michael T. Yin3Ying Huang4Lijun Xu5Qihui Zhou6Biao Zhu7State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, ChinaDivision of Infectious Diseases, Columbia University Medical Center, New York, NY 10032, USAState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, ChinaObjective. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve. Results. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (P=0.008, R2=0.258), HBDH (P=0.001, R2=0.335), and Ferritin (P=0.005, R2=0.237). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 ≤ 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, P<0.001; 1.11 ± 0.72, P=0.043), larger AUC (95% CI 0.781–1.000, P<0.001; 95% CI 0.592–0.917, P=0.043), and more significantly inverse correlation with the oxygenation index. Conclusion. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.http://dx.doi.org/10.1155/2016/1583951 |
| spellingShingle | Jia Sun Junwei Su Yirui Xie Michael T. Yin Ying Huang Lijun Xu Qihui Zhou Biao Zhu Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia Journal of Immunology Research |
| title | Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia |
| title_full | Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia |
| title_fullStr | Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia |
| title_full_unstemmed | Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia |
| title_short | Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia |
| title_sort | plasma il 6 il 10 ratio and il 8 ldh and hbdh level predict the severity and the risk of death in aids patients with pneumocystis pneumonia |
| url | http://dx.doi.org/10.1155/2016/1583951 |
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