Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review
Hypophysis is a small but important human internal gland that regulates the hormonal activity of other glands. Pituitary adenoma (PA) is one of the most common human neoplasias localised in the sphenoid area. Recently, many studies have investigated the causes of PA but the main factors that determ...
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2018-06-01
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| Series: | Neurologijos seminarai |
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| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27839 |
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| author | G. Morkūnaitė B. Glebauskienė R. Liutkevičienė |
| author_facet | G. Morkūnaitė B. Glebauskienė R. Liutkevičienė |
| author_sort | G. Morkūnaitė |
| collection | DOAJ |
| description |
Hypophysis is a small but important human internal gland that regulates the hormonal activity of other glands. Pituitary adenoma (PA) is one of the most common human neoplasias localised in the sphenoid area. Recently, many studies have investigated the causes of PA but the main factors that determine the appearance of PA have not yet been identified. The most important agent of tumors are genes which could determine tumor appearance. One of these factors could be the SIRT1 gene which is important for regulating the metabolic processes and has a significant effect on tumors.
In this article, we will review the PA classification’s innovation, etiology, pathogenesis, SIRT1 polymorphisms and their significance for PA development.
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| format | Article |
| id | doaj-art-57784e4123734d18b1c48c54311e9e7d |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-57784e4123734d18b1c48c54311e9e7d2025-01-20T18:23:16ZengVilnius University PressNeurologijos seminarai1392-30642424-59172018-06-01222(76)10.29014/ns.2018.13Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature reviewG. Morkūnaitė 0B. Glebauskienė 1R. Liutkevičienė 2Lithuanian University of Health SciencesLithuanian University of Health SciencesLithuanian University of Health Sciences Hypophysis is a small but important human internal gland that regulates the hormonal activity of other glands. Pituitary adenoma (PA) is one of the most common human neoplasias localised in the sphenoid area. Recently, many studies have investigated the causes of PA but the main factors that determine the appearance of PA have not yet been identified. The most important agent of tumors are genes which could determine tumor appearance. One of these factors could be the SIRT1 gene which is important for regulating the metabolic processes and has a significant effect on tumors. In this article, we will review the PA classification’s innovation, etiology, pathogenesis, SIRT1 polymorphisms and their significance for PA development. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27839pituitary adenomasirtuins familySIRT1 gene |
| spellingShingle | G. Morkūnaitė B. Glebauskienė R. Liutkevičienė Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review Neurologijos seminarai pituitary adenoma sirtuins family SIRT1 gene |
| title | Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review |
| title_full | Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review |
| title_fullStr | Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review |
| title_full_unstemmed | Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review |
| title_short | Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review |
| title_sort | role of sirtuin 1 sirt1 gene polymorphisms in pituitary adenoma development literature review |
| topic | pituitary adenoma sirtuins family SIRT1 gene |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27839 |
| work_keys_str_mv | AT gmorkunaite roleofsirtuin1sirt1genepolymorphismsinpituitaryadenomadevelopmentliteraturereview AT bglebauskiene roleofsirtuin1sirt1genepolymorphismsinpituitaryadenomadevelopmentliteraturereview AT rliutkeviciene roleofsirtuin1sirt1genepolymorphismsinpituitaryadenomadevelopmentliteraturereview |