Integrating Genomics and Molecular Biology in Understanding Peritoneal Adhesion
Peritoneal adhesions following surgical injury remain a major clinical challenge, often resulting in severe complications, such as intestinal obstruction, chronic pain, and infertility. This review systematically integrates recent genomic and molecular biology insights into the pathogenesis of perit...
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MDPI AG
2025-06-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/6/475 |
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| author | Mirela Lungu Claudiu N. Lungu Andreea Creteanu Mihaela C. Mehedinti |
| author_facet | Mirela Lungu Claudiu N. Lungu Andreea Creteanu Mihaela C. Mehedinti |
| author_sort | Mirela Lungu |
| collection | DOAJ |
| description | Peritoneal adhesions following surgical injury remain a major clinical challenge, often resulting in severe complications, such as intestinal obstruction, chronic pain, and infertility. This review systematically integrates recent genomic and molecular biology insights into the pathogenesis of peritoneal adhesions, explicitly focusing on molecular pathways, including TGF-β signaling, COX-2-mediated inflammatory responses, fibrinolytic balance (tPA/PAI-1), angiogenesis pathways (VEGF, PDGF), and extracellular matrix remodeling (MMPs/TIMPs). Newly conducted transcriptomic and proteomic analyses highlight distinct changes in gene expression patterns in peritoneal fibroblasts during adhesion formation, pinpointing critical roles for integrins, cadherins, selectins, and immunoglobulin superfamily molecules. Recent studies indicate significant shifts in TGF-β isoforms expression, emphasizing isoform-specific impacts on fibrosis and scarring. These insights reveal substantial knowledge gaps, particularly the differential regulatory mechanisms involved in fibrosis versus normal reparative reperitonealization. Future therapeutic strategies could target these molecular pathways and inflammatory mediators to prevent or reduce adhesion formation. Further research into precise genetic markers and the exploration of targeted pharmacological interventions remain pivotal next steps in mitigating postoperative adhesion formation and improving clinical outcomes. |
| format | Article |
| id | doaj-art-57745de2b2a34beb86f2fd0f434eddfa |
| institution | OA Journals |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-57745de2b2a34beb86f2fd0f434eddfa2025-08-20T02:24:38ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-06-0147647510.3390/cimb47060475Integrating Genomics and Molecular Biology in Understanding Peritoneal AdhesionMirela Lungu0Claudiu N. Lungu1Andreea Creteanu2Mihaela C. Mehedinti3Department of Functional and Morphological Science, Faculty of Medicine and Pharmacy, Dunarea de Jos University, 800010 Galati, RomaniaDepartment of Functional and Morphological Science, Faculty of Medicine and Pharmacy, Dunarea de Jos University, 800010 Galati, RomaniaDepartment of Pharmaceutical Technology, University of Medicine and Pharmacy Grigore T Popa, 700115 Iași, RomaniaDepartment of Functional and Morphological Science, Faculty of Medicine and Pharmacy, Dunarea de Jos University, 800010 Galati, RomaniaPeritoneal adhesions following surgical injury remain a major clinical challenge, often resulting in severe complications, such as intestinal obstruction, chronic pain, and infertility. This review systematically integrates recent genomic and molecular biology insights into the pathogenesis of peritoneal adhesions, explicitly focusing on molecular pathways, including TGF-β signaling, COX-2-mediated inflammatory responses, fibrinolytic balance (tPA/PAI-1), angiogenesis pathways (VEGF, PDGF), and extracellular matrix remodeling (MMPs/TIMPs). Newly conducted transcriptomic and proteomic analyses highlight distinct changes in gene expression patterns in peritoneal fibroblasts during adhesion formation, pinpointing critical roles for integrins, cadherins, selectins, and immunoglobulin superfamily molecules. Recent studies indicate significant shifts in TGF-β isoforms expression, emphasizing isoform-specific impacts on fibrosis and scarring. These insights reveal substantial knowledge gaps, particularly the differential regulatory mechanisms involved in fibrosis versus normal reparative reperitonealization. Future therapeutic strategies could target these molecular pathways and inflammatory mediators to prevent or reduce adhesion formation. Further research into precise genetic markers and the exploration of targeted pharmacological interventions remain pivotal next steps in mitigating postoperative adhesion formation and improving clinical outcomes.https://www.mdpi.com/1467-3045/47/6/475peritoneumadhesionadhesion genesperitonitisreintervention |
| spellingShingle | Mirela Lungu Claudiu N. Lungu Andreea Creteanu Mihaela C. Mehedinti Integrating Genomics and Molecular Biology in Understanding Peritoneal Adhesion Current Issues in Molecular Biology peritoneum adhesion adhesion genes peritonitis reintervention |
| title | Integrating Genomics and Molecular Biology in Understanding Peritoneal Adhesion |
| title_full | Integrating Genomics and Molecular Biology in Understanding Peritoneal Adhesion |
| title_fullStr | Integrating Genomics and Molecular Biology in Understanding Peritoneal Adhesion |
| title_full_unstemmed | Integrating Genomics and Molecular Biology in Understanding Peritoneal Adhesion |
| title_short | Integrating Genomics and Molecular Biology in Understanding Peritoneal Adhesion |
| title_sort | integrating genomics and molecular biology in understanding peritoneal adhesion |
| topic | peritoneum adhesion adhesion genes peritonitis reintervention |
| url | https://www.mdpi.com/1467-3045/47/6/475 |
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