Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021
Abstract Introduction Stenotrophomonas maltophilia is an opportunistic pathogen associated with various nosocomial infections and is known for its intrinsic multidrug resistance. This study aims to provide a comprehensive overview of the epidemiology and resistance patterns of S. maltophilia in Chin...
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Adis, Springer Healthcare
2024-12-01
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| Series: | Infectious Diseases and Therapy |
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| Online Access: | https://doi.org/10.1007/s40121-024-01099-7 |
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| author | Hanli Wang Shirong Li Haoyu Ji Yixin Hu Susheng Zhou Xingwu Chen Zhiwei Lu Qinghai You Yusheng Cheng Lei Zha |
| author_facet | Hanli Wang Shirong Li Haoyu Ji Yixin Hu Susheng Zhou Xingwu Chen Zhiwei Lu Qinghai You Yusheng Cheng Lei Zha |
| author_sort | Hanli Wang |
| collection | DOAJ |
| description | Abstract Introduction Stenotrophomonas maltophilia is an opportunistic pathogen associated with various nosocomial infections and is known for its intrinsic multidrug resistance. This study aims to provide a comprehensive overview of the epidemiology and resistance patterns of S. maltophilia in China from 2014 to 2021. Methods Data were extracted from the China Antimicrobial Resistance Surveillance System (CARSS) and the Blood Bacterial Resistance Investigation Collaborative System (BRICS), encompassing 1412 medical institutions across 31 provinces in China. We analyzed the prevalence of S. maltophilia in clinical isolates, focusing on specific patient populations and departments, as well as resistance profiles to recommended first-line antibiotics, including sulfamethoxazole-trimethoprim, levofloxacin, and minocycline. Results A total of 514,768 S. maltophilia strains were analyzed. The overall prevalence of S. maltophilia among all clinical bacterial isolates remained stable at approximately 2.1%, with higher rates observed in intensive care units and elderly patients. Resistance rates to sulfamethoxazole-trimethoprim decreased from 9.8% in 2014 to 7.5% in 2021. In contrast, resistance to levofloxacin showed a slight upward trend, increasing from 8.5% in 2014 to 9.5% in 2021. Meanwhile, minocycline resistance remained low, fluctuating marginally from 2.7% in 2014 to 1.7% in 2021. Conclusions This study highlights the stable prevalence of S. maltophilia in clinical settings in China and the overall low resistance rates to recommended first-line antibiotics. However, alarmingly high resistance rates were observed in specific specimen types, particularly in blood cultures, suggesting that minocycline may be the only reliable therapeutic option among the six tested antibiotics for treating such infections in China. Continuous surveillance and effective infection control measures are essential to manage S. maltophilia infections, particularly in vulnerable populations. Future research should focus on measuring the true burden of these infections and monitoring the susceptibility of the newly introduced antibiotics, such as cefiderocol. |
| format | Article |
| id | doaj-art-577402dc320d4c26a417038434f58766 |
| institution | Kabale University |
| issn | 2193-8229 2193-6382 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj-art-577402dc320d4c26a417038434f587662025-02-02T12:35:25ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822024-12-0114126127410.1007/s40121-024-01099-7Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021Hanli Wang0Shirong Li1Haoyu Ji2Yixin Hu3Susheng Zhou4Xingwu Chen5Zhiwei Lu6Qinghai You7Yusheng Cheng8Lei Zha9Department of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical CollegePulmonary and Critical Care Department, The Second People’s Hospital of WuhuDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical CollegeXi’an Jiaotong-Liverpool UniversityDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical CollegeAbstract Introduction Stenotrophomonas maltophilia is an opportunistic pathogen associated with various nosocomial infections and is known for its intrinsic multidrug resistance. This study aims to provide a comprehensive overview of the epidemiology and resistance patterns of S. maltophilia in China from 2014 to 2021. Methods Data were extracted from the China Antimicrobial Resistance Surveillance System (CARSS) and the Blood Bacterial Resistance Investigation Collaborative System (BRICS), encompassing 1412 medical institutions across 31 provinces in China. We analyzed the prevalence of S. maltophilia in clinical isolates, focusing on specific patient populations and departments, as well as resistance profiles to recommended first-line antibiotics, including sulfamethoxazole-trimethoprim, levofloxacin, and minocycline. Results A total of 514,768 S. maltophilia strains were analyzed. The overall prevalence of S. maltophilia among all clinical bacterial isolates remained stable at approximately 2.1%, with higher rates observed in intensive care units and elderly patients. Resistance rates to sulfamethoxazole-trimethoprim decreased from 9.8% in 2014 to 7.5% in 2021. In contrast, resistance to levofloxacin showed a slight upward trend, increasing from 8.5% in 2014 to 9.5% in 2021. Meanwhile, minocycline resistance remained low, fluctuating marginally from 2.7% in 2014 to 1.7% in 2021. Conclusions This study highlights the stable prevalence of S. maltophilia in clinical settings in China and the overall low resistance rates to recommended first-line antibiotics. However, alarmingly high resistance rates were observed in specific specimen types, particularly in blood cultures, suggesting that minocycline may be the only reliable therapeutic option among the six tested antibiotics for treating such infections in China. Continuous surveillance and effective infection control measures are essential to manage S. maltophilia infections, particularly in vulnerable populations. Future research should focus on measuring the true burden of these infections and monitoring the susceptibility of the newly introduced antibiotics, such as cefiderocol.https://doi.org/10.1007/s40121-024-01099-7Antimicrobial resistanceEpidemiologyInfection controlNosocomial infectionsStenotrophomonas maltophilia |
| spellingShingle | Hanli Wang Shirong Li Haoyu Ji Yixin Hu Susheng Zhou Xingwu Chen Zhiwei Lu Qinghai You Yusheng Cheng Lei Zha Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021 Infectious Diseases and Therapy Antimicrobial resistance Epidemiology Infection control Nosocomial infections Stenotrophomonas maltophilia |
| title | Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021 |
| title_full | Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021 |
| title_fullStr | Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021 |
| title_full_unstemmed | Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021 |
| title_short | Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021 |
| title_sort | epidemiology and antimicrobial resistance of stenotrophomonas maltophilia in china 2014 2021 |
| topic | Antimicrobial resistance Epidemiology Infection control Nosocomial infections Stenotrophomonas maltophilia |
| url | https://doi.org/10.1007/s40121-024-01099-7 |
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