Pain persists in mice lacking both Substance P and CGRPα signaling

Pain persists in mice lacking both Substance P and CGRPα signaling

The neuropeptides Substance P and CGRPα have long been thought important for pain sensation. Both peptides and their receptors are expressed at high levels in pain-responsive neurons from the periphery to the brain making them attractive therapeutic targets. However, drugs targeting these pathways i...

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Bibliographic Details
Main Authors: Donald Iain MacDonald, Monessha Jayabalan, Jonathan T Seaman, Rakshita Balaji, Alec R Nickolls, Alexander Theodore Chesler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-03-01
Series:eLife
Subjects:
pain
somatosensation
neuropeptides
Online Access:https://elifesciences.org/articles/93754
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