Multiple Myeloma with Foamy Mott Cells
Intracytoplasmic assorted vacuoles containing immunoglobulin collections are occasionally seen in multiple myeloma. When abundant, they impart a foamy appearance to the tumor cells, which is a potential source for diagnostic pitfalls. Herein, we report the case of a patient who presented with skelet...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2021/7391895 |
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| _version_ | 1832565233859690496 |
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| author | Karen Nalbandyan Daniel Benharroch Benzion Samueli Michael Kafka Anna Gourevitch |
| author_facet | Karen Nalbandyan Daniel Benharroch Benzion Samueli Michael Kafka Anna Gourevitch |
| author_sort | Karen Nalbandyan |
| collection | DOAJ |
| description | Intracytoplasmic assorted vacuoles containing immunoglobulin collections are occasionally seen in multiple myeloma. When abundant, they impart a foamy appearance to the tumor cells, which is a potential source for diagnostic pitfalls. Herein, we report the case of a patient who presented with skeletal pain and CT confirmed lytic lesions. A bone marrow biopsy revealed multiple myeloma with unusual foamy Mott cells. The patient was subsequently treated with four cycles of cyclophosphamide, bortezomib, and dexamethasone induction therapy, followed by 3 cycles of lenalidomide with dexamethasone. A biopsy performed following initial biological and immunomodulatory drugs revealed different morphological and clonal characteristics. These features were modified again, five years later, and again, after two years of close monitoring. Hematopathologists should be aware of this morphologic variant of myeloma as well as for the capacity of clonal characteristics, such as light chain monotype, to fluctuate subsequent to treatment. |
| format | Article |
| id | doaj-art-576c62dc34044f9b85f509a6dda8e6be |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-576c62dc34044f9b85f509a6dda8e6be2025-02-03T01:08:51ZengWileyCase Reports in Hematology2090-65602090-65792021-01-01202110.1155/2021/73918957391895Multiple Myeloma with Foamy Mott CellsKaren Nalbandyan0Daniel Benharroch1Benzion Samueli2Michael Kafka3Anna Gourevitch4Department of Pathology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Pathology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Pathology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDivision of Hematology, Hematology Laboratory, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, IsraelDivision of Hematology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelIntracytoplasmic assorted vacuoles containing immunoglobulin collections are occasionally seen in multiple myeloma. When abundant, they impart a foamy appearance to the tumor cells, which is a potential source for diagnostic pitfalls. Herein, we report the case of a patient who presented with skeletal pain and CT confirmed lytic lesions. A bone marrow biopsy revealed multiple myeloma with unusual foamy Mott cells. The patient was subsequently treated with four cycles of cyclophosphamide, bortezomib, and dexamethasone induction therapy, followed by 3 cycles of lenalidomide with dexamethasone. A biopsy performed following initial biological and immunomodulatory drugs revealed different morphological and clonal characteristics. These features were modified again, five years later, and again, after two years of close monitoring. Hematopathologists should be aware of this morphologic variant of myeloma as well as for the capacity of clonal characteristics, such as light chain monotype, to fluctuate subsequent to treatment.http://dx.doi.org/10.1155/2021/7391895 |
| spellingShingle | Karen Nalbandyan Daniel Benharroch Benzion Samueli Michael Kafka Anna Gourevitch Multiple Myeloma with Foamy Mott Cells Case Reports in Hematology |
| title | Multiple Myeloma with Foamy Mott Cells |
| title_full | Multiple Myeloma with Foamy Mott Cells |
| title_fullStr | Multiple Myeloma with Foamy Mott Cells |
| title_full_unstemmed | Multiple Myeloma with Foamy Mott Cells |
| title_short | Multiple Myeloma with Foamy Mott Cells |
| title_sort | multiple myeloma with foamy mott cells |
| url | http://dx.doi.org/10.1155/2021/7391895 |
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