Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as Reference
Objective: To compare the diagnostic performance between mDixon sequence and WHCA TFE sequence using SPIR for non-contrast-enhanced coronary MRA in patients with suspected coronary artery disease (CAD). Method: This prospective study recruited 45 patients who were scheduled for X-ray coronary angiog...
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Editorial Office of Computerized Tomography Theory and Application
2025-01-01
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| Series: | CT Lilun yu yingyong yanjiu |
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| Online Access: | https://www.cttacn.org.cn/cn/article/doi/10.15953/j.ctta.2024.185 |
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| author | Huaying WANG Yang CHEN Peng HUANG Yue LI Gang ZHANG Zhongsheng ZHANG Haixia JI Hao GUO Heng MA |
| author_facet | Huaying WANG Yang CHEN Peng HUANG Yue LI Gang ZHANG Zhongsheng ZHANG Haixia JI Hao GUO Heng MA |
| author_sort | Huaying WANG |
| collection | DOAJ |
| description | Objective: To compare the diagnostic performance between mDixon sequence and WHCA TFE sequence using SPIR for non-contrast-enhanced coronary MRA in patients with suspected coronary artery disease (CAD). Method: This prospective study recruited 45 patients who were scheduled for X-ray coronary angiography (CAG) with suspected CAD in Yantai Yuhuangding hospital. Patients underwent both 3.0T WHCA TFE using SPIR and mDixon coronary MRA examinations before undergoing CAG. Two radiologists independently assessed coronary arteries in terms of subjective image quality (on a scale of 1~5, with 5 denoting the highest image quality), vessel length, vessel diameter, and presence of significant stenoses. CAG was used as the reference standard for detecting the presence of stenoses. Vessel length and diameter were compared between sequences using paired t-tests. Subjective image quality scores were compared between sequences using Wilcoxon tests. Sensitivity, specificity, and accuracy were compared between sequences using McNemar tests. Positive and negative predictive values were compared between sequences using the joint hypotheses test. Results: Two CMRA examinations were successfully performed in 40 (88.9%) of 45 patients for analysis. The objective image quality of 3.0T mDixon assessed by both radiologists was (3.9±0.9), and the 3.0T WHCA TFE using SPIR was (3.7±0.9). The mDixon sequence exhibited higher sensitivity, specificity, accuracy, positive predictive value, and negative predictive value in per-segment analysis (78.5% vs. 66.1%, 96.5% vs. 93.8%, 91.7% vs. 86.6%, 88.6% vs. 78.9%, and 93.4% vs. 88.7%) and higher sensitivity and accuracy in per-vessel analysis (89.4% vs. 81.6% and 89.1% vs. 83.3%). Conclusion: In comparison with 3.0T WHCA TFE sequence using SPIR, mDixon demonstrated superior diagnostic performance. |
| format | Article |
| id | doaj-art-573bb7ad0bf74b6d97a262bb519c2556 |
| institution | Kabale University |
| issn | 1004-4140 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of Computerized Tomography Theory and Application |
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| series | CT Lilun yu yingyong yanjiu |
| spelling | doaj-art-573bb7ad0bf74b6d97a262bb519c25562025-01-21T09:14:43ZengEditorial Office of Computerized Tomography Theory and ApplicationCT Lilun yu yingyong yanjiu1004-41402025-01-0134191610.15953/j.ctta.2024.1852024.185Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as ReferenceHuaying WANG0Yang CHEN1Peng HUANG2Yue LI3Gang ZHANG4Zhongsheng ZHANG5Haixia JI6Hao GUO7Heng MA8Department of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaDepartment of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaDepartment of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaDepartment of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaDepartment of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaDepartment of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaDepartment of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaDepartment of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaDepartment of Radiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, ChinaObjective: To compare the diagnostic performance between mDixon sequence and WHCA TFE sequence using SPIR for non-contrast-enhanced coronary MRA in patients with suspected coronary artery disease (CAD). Method: This prospective study recruited 45 patients who were scheduled for X-ray coronary angiography (CAG) with suspected CAD in Yantai Yuhuangding hospital. Patients underwent both 3.0T WHCA TFE using SPIR and mDixon coronary MRA examinations before undergoing CAG. Two radiologists independently assessed coronary arteries in terms of subjective image quality (on a scale of 1~5, with 5 denoting the highest image quality), vessel length, vessel diameter, and presence of significant stenoses. CAG was used as the reference standard for detecting the presence of stenoses. Vessel length and diameter were compared between sequences using paired t-tests. Subjective image quality scores were compared between sequences using Wilcoxon tests. Sensitivity, specificity, and accuracy were compared between sequences using McNemar tests. Positive and negative predictive values were compared between sequences using the joint hypotheses test. Results: Two CMRA examinations were successfully performed in 40 (88.9%) of 45 patients for analysis. The objective image quality of 3.0T mDixon assessed by both radiologists was (3.9±0.9), and the 3.0T WHCA TFE using SPIR was (3.7±0.9). The mDixon sequence exhibited higher sensitivity, specificity, accuracy, positive predictive value, and negative predictive value in per-segment analysis (78.5% vs. 66.1%, 96.5% vs. 93.8%, 91.7% vs. 86.6%, 88.6% vs. 78.9%, and 93.4% vs. 88.7%) and higher sensitivity and accuracy in per-vessel analysis (89.4% vs. 81.6% and 89.1% vs. 83.3%). Conclusion: In comparison with 3.0T WHCA TFE sequence using SPIR, mDixon demonstrated superior diagnostic performance.https://www.cttacn.org.cn/cn/article/doi/10.15953/j.ctta.2024.185coronary angiography magnetic resonancecoronary artery stenosesdiagnostic performance |
| spellingShingle | Huaying WANG Yang CHEN Peng HUANG Yue LI Gang ZHANG Zhongsheng ZHANG Haixia JI Hao GUO Heng MA Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as Reference CT Lilun yu yingyong yanjiu coronary angiography magnetic resonance coronary artery stenoses diagnostic performance |
| title | Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as Reference |
| title_full | Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as Reference |
| title_fullStr | Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as Reference |
| title_full_unstemmed | Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as Reference |
| title_short | Non-contrast-enhanced 3.0T Whole-heart Coronary MRA: Comparison of Diagnostic Performance between mDixon and WHCA TFE Sequence Using SPIR in CAD Using Coronary Angiography as Reference |
| title_sort | non contrast enhanced 3 0t whole heart coronary mra comparison of diagnostic performance between mdixon and whca tfe sequence using spir in cad using coronary angiography as reference |
| topic | coronary angiography magnetic resonance coronary artery stenoses diagnostic performance |
| url | https://www.cttacn.org.cn/cn/article/doi/10.15953/j.ctta.2024.185 |
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