Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats
Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BE...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2014/532969 |
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| author | Vijay K. Bharti R. S. Srivastava H. Kumar S. Bag A. C. Majumdar G. Singh S. R. Pandi-Perumal Gregory M. Brown |
| author_facet | Vijay K. Bharti R. S. Srivastava H. Kumar S. Bag A. C. Majumdar G. Singh S. R. Pandi-Perumal Gregory M. Brown |
| author_sort | Vijay K. Bharti |
| collection | DOAJ |
| description | Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart, liver, and kidney of experimental adult female rats. To accomplish this experimental objective, twenty-four adult female Wistar rats (123–143 g body weights) were divided into four groups, namely, control, F, F + BEP, and F + MEL and were administered sodium fluoride (NaF, 150 ppm elemental F in drinking water), MEL (10 mg/kg BW, i.p.), and BEP (100 µg/kg BW, i.p.) for 28 days. There were significantly P<0.05 high levels of lipid peroxidation and catalase and low levels of reduced glutathione, superoxide dismutase, glutathione reductase, and glutathione peroxidase in cardiac, hepatic, and renal tissues of F-treated rats. Administration of BEP and MEL in F-treated rats, however, significantly P<0.05 attenuated these adverse changes in all the target components of antioxidant defense system of cardiac, hepatic, and renal tissues. The present data suggest that F can induce oxidative stress in liver, heart, and kidney of female rats which may be a mechanism in F toxicity and these adverse effects can be ameliorated by buffalo (Bubalus bubalis) epiphyseal proteins and melatonin by upregulation of antioxidant defense system of heart, liver, and kidney of rats. |
| format | Article |
| id | doaj-art-572ad92c29964ef6b85fff87ac7d29c1 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-572ad92c29964ef6b85fff87ac7d29c12025-02-03T01:22:35ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422014-01-01201410.1155/2014/532969532969Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of RatsVijay K. Bharti0R. S. Srivastava1H. Kumar2S. Bag3A. C. Majumdar4G. Singh5S. R. Pandi-Perumal6Gregory M. Brown7Division of Physiology and Climatology, Indian Veterinary Research Institute (IVRI), Izatnagar, Uttar Pradesh 243122, IndiaDivision of Physiology and Climatology, Indian Veterinary Research Institute (IVRI), Izatnagar, Uttar Pradesh 243122, IndiaDivision of Animal Reproduction, Indian Veterinary Research Institute (IVRI), Izatnagar, Uttar Pradesh 243122, IndiaDivision of Physiology and Climatology, Indian Veterinary Research Institute (IVRI), Izatnagar, Uttar Pradesh 243122, IndiaDivision of Physiology and Climatology, Indian Veterinary Research Institute (IVRI), Izatnagar, Uttar Pradesh 243122, IndiaDivision of Physiology and Climatology, Indian Veterinary Research Institute (IVRI), Izatnagar, Uttar Pradesh 243122, IndiaSomnogen Inc., College Street, Toronto, ON, M6H 1C5, CanadaDepartment of Psychiatry, Faculty of Medicine, University of Toronto and Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, CanadaSeveral experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart, liver, and kidney of experimental adult female rats. To accomplish this experimental objective, twenty-four adult female Wistar rats (123–143 g body weights) were divided into four groups, namely, control, F, F + BEP, and F + MEL and were administered sodium fluoride (NaF, 150 ppm elemental F in drinking water), MEL (10 mg/kg BW, i.p.), and BEP (100 µg/kg BW, i.p.) for 28 days. There were significantly P<0.05 high levels of lipid peroxidation and catalase and low levels of reduced glutathione, superoxide dismutase, glutathione reductase, and glutathione peroxidase in cardiac, hepatic, and renal tissues of F-treated rats. Administration of BEP and MEL in F-treated rats, however, significantly P<0.05 attenuated these adverse changes in all the target components of antioxidant defense system of cardiac, hepatic, and renal tissues. The present data suggest that F can induce oxidative stress in liver, heart, and kidney of female rats which may be a mechanism in F toxicity and these adverse effects can be ameliorated by buffalo (Bubalus bubalis) epiphyseal proteins and melatonin by upregulation of antioxidant defense system of heart, liver, and kidney of rats.http://dx.doi.org/10.1155/2014/532969 |
| spellingShingle | Vijay K. Bharti R. S. Srivastava H. Kumar S. Bag A. C. Majumdar G. Singh S. R. Pandi-Perumal Gregory M. Brown Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats Advances in Pharmacological Sciences |
| title | Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats |
| title_full | Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats |
| title_fullStr | Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats |
| title_full_unstemmed | Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats |
| title_short | Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats |
| title_sort | effects of melatonin and epiphyseal proteins on fluoride induced adverse changes in antioxidant status of heart liver and kidney of rats |
| url | http://dx.doi.org/10.1155/2014/532969 |
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