Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration
Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and mental health of patients. Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. Regenerative medicine involving stem cells has ente...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/8882505 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552848032792576 |
|---|---|
| author | Shuangpeng Jiang Guangzhao Tian Xu Li Zhen Yang Fuxin Wang Zhuang Tian Bo Huang Fu Wei Kangkang Zha Zhiqiang Sun Xiang Sui Shuyun Liu Weimin Guo Quanyi Guo |
| author_facet | Shuangpeng Jiang Guangzhao Tian Xu Li Zhen Yang Fuxin Wang Zhuang Tian Bo Huang Fu Wei Kangkang Zha Zhiqiang Sun Xiang Sui Shuyun Liu Weimin Guo Quanyi Guo |
| author_sort | Shuangpeng Jiang |
| collection | DOAJ |
| description | Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and mental health of patients. Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. Regenerative medicine involving stem cells has entered a new stage and is considered the most promising way to regenerate articular cartilage. In terms of theories on the mechanism, it was thought that stem cell-mediated articular cartilage regeneration was achieved through the directional differentiation of stem cells into chondrocytes. However, recent evidence has shown that the stem cell secretome plays an important role in biological processes such as the immune response, inflammation regulation, and drug delivery. At the same time, the stem cell secretome can effectively mediate the process of tissue regeneration. This new theory has attributed the therapeutic effect of stem cells to their paracrine effects. The application of stem cells is not limited to exogenous stem cell transplantation. Endogenous stem cell homing and in situ regeneration strategies have received extensive attention. The application of stem cell derivatives, such as conditioned media, extracellular vesicles, and extracellular matrix, is an extension of stem cell paracrine theory. On the other hand, stem cell pretreatment strategies have also shown promising therapeutic effects. This article will systematically review the latest developments in these areas, summarize challenges in articular cartilage regeneration strategies involving stem cells, and describe prospects for future development. |
| format | Article |
| id | doaj-art-5725e2c0abbe440bbc6640224ae3f92f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5725e2c0abbe440bbc6640224ae3f92f2025-02-03T05:57:35ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/88825058882505Research Progress on Stem Cell Therapies for Articular Cartilage RegenerationShuangpeng Jiang0Guangzhao Tian1Xu Li2Zhen Yang3Fuxin Wang4Zhuang Tian5Bo Huang6Fu Wei7Kangkang Zha8Zhiqiang Sun9Xiang Sui10Shuyun Liu11Weimin Guo12Quanyi Guo13Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Orthopedics, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001 Liaoning Province, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInstitute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, ChinaInjury of articular cartilage can cause osteoarthritis and seriously affect the physical and mental health of patients. Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. Regenerative medicine involving stem cells has entered a new stage and is considered the most promising way to regenerate articular cartilage. In terms of theories on the mechanism, it was thought that stem cell-mediated articular cartilage regeneration was achieved through the directional differentiation of stem cells into chondrocytes. However, recent evidence has shown that the stem cell secretome plays an important role in biological processes such as the immune response, inflammation regulation, and drug delivery. At the same time, the stem cell secretome can effectively mediate the process of tissue regeneration. This new theory has attributed the therapeutic effect of stem cells to their paracrine effects. The application of stem cells is not limited to exogenous stem cell transplantation. Endogenous stem cell homing and in situ regeneration strategies have received extensive attention. The application of stem cell derivatives, such as conditioned media, extracellular vesicles, and extracellular matrix, is an extension of stem cell paracrine theory. On the other hand, stem cell pretreatment strategies have also shown promising therapeutic effects. This article will systematically review the latest developments in these areas, summarize challenges in articular cartilage regeneration strategies involving stem cells, and describe prospects for future development.http://dx.doi.org/10.1155/2021/8882505 |
| spellingShingle | Shuangpeng Jiang Guangzhao Tian Xu Li Zhen Yang Fuxin Wang Zhuang Tian Bo Huang Fu Wei Kangkang Zha Zhiqiang Sun Xiang Sui Shuyun Liu Weimin Guo Quanyi Guo Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration Stem Cells International |
| title | Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration |
| title_full | Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration |
| title_fullStr | Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration |
| title_full_unstemmed | Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration |
| title_short | Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration |
| title_sort | research progress on stem cell therapies for articular cartilage regeneration |
| url | http://dx.doi.org/10.1155/2021/8882505 |
| work_keys_str_mv | AT shuangpengjiang researchprogressonstemcelltherapiesforarticularcartilageregeneration AT guangzhaotian researchprogressonstemcelltherapiesforarticularcartilageregeneration AT xuli researchprogressonstemcelltherapiesforarticularcartilageregeneration AT zhenyang researchprogressonstemcelltherapiesforarticularcartilageregeneration AT fuxinwang researchprogressonstemcelltherapiesforarticularcartilageregeneration AT zhuangtian researchprogressonstemcelltherapiesforarticularcartilageregeneration AT bohuang researchprogressonstemcelltherapiesforarticularcartilageregeneration AT fuwei researchprogressonstemcelltherapiesforarticularcartilageregeneration AT kangkangzha researchprogressonstemcelltherapiesforarticularcartilageregeneration AT zhiqiangsun researchprogressonstemcelltherapiesforarticularcartilageregeneration AT xiangsui researchprogressonstemcelltherapiesforarticularcartilageregeneration AT shuyunliu researchprogressonstemcelltherapiesforarticularcartilageregeneration AT weiminguo researchprogressonstemcelltherapiesforarticularcartilageregeneration AT quanyiguo researchprogressonstemcelltherapiesforarticularcartilageregeneration |