Primary Graft Failure after Heart Transplantation
Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. In the last decade, advances in pharmacologi...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/175768 |
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| _version_ | 1850223416910544896 |
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| author | Arjun Iyer Gayathri Kumarasinghe Mark Hicks Alasdair Watson Ling Gao Aoife Doyle Anne Keogh Eugene Kotlyar Christopher Hayward Kumud Dhital Emily Granger Paul Jansz Roger Pye Phillip Spratt Peter Simon Macdonald |
| author_facet | Arjun Iyer Gayathri Kumarasinghe Mark Hicks Alasdair Watson Ling Gao Aoife Doyle Anne Keogh Eugene Kotlyar Christopher Hayward Kumud Dhital Emily Granger Paul Jansz Roger Pye Phillip Spratt Peter Simon Macdonald |
| author_sort | Arjun Iyer |
| collection | DOAJ |
| description | Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. In the last decade, advances in pharmacological treatment and mechanical circulatory support have improved the outlook for heart transplant recipients who develop this complication. Despite these advances in treatment, PGF is still the leading cause of death in the first 30 days after transplantation. In today's climate of significant organ shortages and growing waiting lists, transplant units worldwide have increasingly utilised “marginal donors” to try and bridge the gap between “supply and demand.” One of the costs of this strategy has been an increased incidence of PGF. As the threat of PGF increases, the challenges of predicting and preventing its occurrence, as well as the identification of more effective treatment modalities, are vital areas of active research and development. |
| format | Article |
| id | doaj-art-57224c6a85f149b9b0a3c1af4bd834ae |
| institution | OA Journals |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-57224c6a85f149b9b0a3c1af4bd834ae2025-08-20T02:05:57ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/175768175768Primary Graft Failure after Heart TransplantationArjun Iyer0Gayathri Kumarasinghe1Mark Hicks2Alasdair Watson3Ling Gao4Aoife Doyle5Anne Keogh6Eugene Kotlyar7Christopher Hayward8Kumud Dhital9Emily Granger10Paul Jansz11Roger Pye12Phillip Spratt13Peter Simon Macdonald14Heart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaCardiac Physiology and Transplant Program, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, AustraliaCardiac Physiology and Transplant Program, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, AustraliaCardiac Physiology and Transplant Program, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, AustraliaCardiac Physiology and Transplant Program, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaHeart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, AustraliaPrimary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. In the last decade, advances in pharmacological treatment and mechanical circulatory support have improved the outlook for heart transplant recipients who develop this complication. Despite these advances in treatment, PGF is still the leading cause of death in the first 30 days after transplantation. In today's climate of significant organ shortages and growing waiting lists, transplant units worldwide have increasingly utilised “marginal donors” to try and bridge the gap between “supply and demand.” One of the costs of this strategy has been an increased incidence of PGF. As the threat of PGF increases, the challenges of predicting and preventing its occurrence, as well as the identification of more effective treatment modalities, are vital areas of active research and development.http://dx.doi.org/10.1155/2011/175768 |
| spellingShingle | Arjun Iyer Gayathri Kumarasinghe Mark Hicks Alasdair Watson Ling Gao Aoife Doyle Anne Keogh Eugene Kotlyar Christopher Hayward Kumud Dhital Emily Granger Paul Jansz Roger Pye Phillip Spratt Peter Simon Macdonald Primary Graft Failure after Heart Transplantation Journal of Transplantation |
| title | Primary Graft Failure after Heart Transplantation |
| title_full | Primary Graft Failure after Heart Transplantation |
| title_fullStr | Primary Graft Failure after Heart Transplantation |
| title_full_unstemmed | Primary Graft Failure after Heart Transplantation |
| title_short | Primary Graft Failure after Heart Transplantation |
| title_sort | primary graft failure after heart transplantation |
| url | http://dx.doi.org/10.1155/2011/175768 |
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