The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin
Abstract We study the prevalence of SARS-CoV-2 antibodies in a diverse population in Milwaukee County, Wisconsin from May 2021 to June 2022. We find that 99.4% (523/526) of the participants had positive results for antibodies to the SARS CoV2 spike protein over April-June 2022, soon after the early-...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-76946-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571654999375872 |
|---|---|
| author | Lorenzo Franchi Vladimir Atanasov Mark Stake Garrett Bates Kristen Osinski John R Meurer Bernard Black |
| author_facet | Lorenzo Franchi Vladimir Atanasov Mark Stake Garrett Bates Kristen Osinski John R Meurer Bernard Black |
| author_sort | Lorenzo Franchi |
| collection | DOAJ |
| description | Abstract We study the prevalence of SARS-CoV-2 antibodies in a diverse population in Milwaukee County, Wisconsin from May 2021 to June 2022. We find that 99.4% (523/526) of the participants had positive results for antibodies to the SARS CoV2 spike protein over April-June 2022, soon after the early-2022 Omicron surge. Positive tests for spike protein antibodies were very high (86%; 19/22) even among unvaccinated persons who reported no knowledge of prior infection. Thus, by mid-2022, almost all persons were no longer COVID-naïve, defined as vaccination, infection (often without symptoms), or both. Nucleocapsid antibody tests, especially the Abbott test, were far less sensitive than spike protein tests, and Abbott test sensitivity faded with time since infection. Thus, studies which rely on nucleocapsid tests will understate prior infection rates. We also report large sample evidence on the performance of the Abbott and Roche spike and nucleocapsid protein tests in capturing prior vaccination, infection, or both. The Roche spike protein test outperforms the Abbott spike test, and the Roche nucleocapsid test greatly outperforms the Abbott nucleocapsid test. |
| format | Article |
| id | doaj-art-571b2ce0d4d9425fb0c5aa5eb57fa7db |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-571b2ce0d4d9425fb0c5aa5eb57fa7db2025-02-02T12:24:51ZengNature PortfolioScientific Reports2045-23222024-11-011411910.1038/s41598-024-76946-1The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, WisconsinLorenzo Franchi0Vladimir Atanasov1Mark Stake2Garrett Bates3Kristen Osinski4John R Meurer5Bernard Black6Northwestern Pritzker School of LawWilliam & Mary, Mason School of BusinessMedical College of WisconsinMedical College of WisconsinMedical College of WisconsinMedical College of WisconsinNorthwestern Pritzker School of LawAbstract We study the prevalence of SARS-CoV-2 antibodies in a diverse population in Milwaukee County, Wisconsin from May 2021 to June 2022. We find that 99.4% (523/526) of the participants had positive results for antibodies to the SARS CoV2 spike protein over April-June 2022, soon after the early-2022 Omicron surge. Positive tests for spike protein antibodies were very high (86%; 19/22) even among unvaccinated persons who reported no knowledge of prior infection. Thus, by mid-2022, almost all persons were no longer COVID-naïve, defined as vaccination, infection (often without symptoms), or both. Nucleocapsid antibody tests, especially the Abbott test, were far less sensitive than spike protein tests, and Abbott test sensitivity faded with time since infection. Thus, studies which rely on nucleocapsid tests will understate prior infection rates. We also report large sample evidence on the performance of the Abbott and Roche spike and nucleocapsid protein tests in capturing prior vaccination, infection, or both. The Roche spike protein test outperforms the Abbott spike test, and the Roche nucleocapsid test greatly outperforms the Abbott nucleocapsid test.https://doi.org/10.1038/s41598-024-76946-1COVID-19SARS-CoV-2AntibodiesAbbott antibodies testRoche antibodies testSpike test |
| spellingShingle | Lorenzo Franchi Vladimir Atanasov Mark Stake Garrett Bates Kristen Osinski John R Meurer Bernard Black The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin Scientific Reports COVID-19 SARS-CoV-2 Antibodies Abbott antibodies test Roche antibodies test Spike test |
| title | The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin |
| title_full | The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin |
| title_fullStr | The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin |
| title_full_unstemmed | The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin |
| title_short | The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin |
| title_sort | disappearing covid naive population and comparative roche vs abbott test sensitivity evidence from antibody seroprevalence in milwaukee county wisconsin |
| topic | COVID-19 SARS-CoV-2 Antibodies Abbott antibodies test Roche antibodies test Spike test |
| url | https://doi.org/10.1038/s41598-024-76946-1 |
| work_keys_str_mv | AT lorenzofranchi thedisappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT vladimiratanasov thedisappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT markstake thedisappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT garrettbates thedisappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT kristenosinski thedisappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT johnrmeurer thedisappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT bernardblack thedisappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT lorenzofranchi disappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT vladimiratanasov disappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT markstake disappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT garrettbates disappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT kristenosinski disappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT johnrmeurer disappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin AT bernardblack disappearingcovidnaivepopulationandcomparativerochevsabbotttestsensitivityevidencefromantibodyseroprevalenceinmilwaukeecountywisconsin |