Iron(III)-catalyzed activation of C(sp2)-H and C(sp3)-H bonds for H/D exchange of arenes
Abstract Iron-catalyzed C-H activation reactions via organometallic Fe-C intermediates have been extensively studied during the past two decades. One issue remains to be clarified is whether iron(III) salts containing weakly coordinating anions could directly activate C(sp2)-H or C(sp3)-H bonds with...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61428-3 |
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| Summary: | Abstract Iron-catalyzed C-H activation reactions via organometallic Fe-C intermediates have been extensively studied during the past two decades. One issue remains to be clarified is whether iron(III) salts containing weakly coordinating anions could directly activate C(sp2)-H or C(sp3)-H bonds without the assistance of a directing group. Herein, we report our finding that iron(III) salts containing weakly coordinating anions can indeed be effective catalyst for the direct activation of C(sp2)-H and C(sp3)-H bonds under weakly coordinating environment. This mechanism could be extended to other types of first-row transition metal complexes such as Co(II), Ni(II), and Cu(II). Thus, an iron(III) catalyzed H/D exchange reaction for aromatic C(sp2)-H bonds and the corresponding β-C(sp3)-H bonds of the alkyl substituents is developed, unlocking an easy access to the valuable deuterated aromatic products from feedstock chemicals. |
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| ISSN: | 2041-1723 |