Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers
Exosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly in facilitating drug resistance. This article delves into the emerging evidence linking exosomal lncRNAs to the modulation of drug resistance mechanism...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1485422/full |
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| author | Nooshafarin Shirani Neda Abdi Matin Chehelgerdi Matin Chehelgerdi Hajar Yaghoobi Mohammad Chehelgerdi Mohammad Chehelgerdi |
| author_facet | Nooshafarin Shirani Neda Abdi Matin Chehelgerdi Matin Chehelgerdi Hajar Yaghoobi Mohammad Chehelgerdi Mohammad Chehelgerdi |
| author_sort | Nooshafarin Shirani |
| collection | DOAJ |
| description | Exosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly in facilitating drug resistance. This article delves into the emerging evidence linking exosomal lncRNAs to the modulation of drug resistance mechanisms in cancers such as ovarian, cervical, and endometrial cancer. It synthesizes current research findings on how these lncRNAs influence cancer cell survival, tumor microenvironment, and chemotherapy efficacy. Additionally, the review highlights potential therapeutic strategies targeting exosomal lncRNAs, proposing a new frontier in overcoming drug resistance. By mapping the interface of exosomal lncRNAs and drug resistance, this article aims to provide a comprehensive understanding that could pave the way for innovative treatments and improved patient outcomes in female reproductive system cancers. |
| format | Article |
| id | doaj-art-5714a199a0d946f2a4739be30c896980 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-5714a199a0d946f2a4739be30c8969802025-01-24T07:13:55ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011310.3389/fcell.2025.14854221485422Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancersNooshafarin Shirani0Neda Abdi1Matin Chehelgerdi2Matin Chehelgerdi3Hajar Yaghoobi4Mohammad Chehelgerdi5Mohammad Chehelgerdi6Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranClinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranNovin Genome (NG) Lab, Research and Development Center for Biotechnology, Shahrekord, IranYoung Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, IranClinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranNovin Genome (NG) Lab, Research and Development Center for Biotechnology, Shahrekord, IranYoung Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, IranExosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly in facilitating drug resistance. This article delves into the emerging evidence linking exosomal lncRNAs to the modulation of drug resistance mechanisms in cancers such as ovarian, cervical, and endometrial cancer. It synthesizes current research findings on how these lncRNAs influence cancer cell survival, tumor microenvironment, and chemotherapy efficacy. Additionally, the review highlights potential therapeutic strategies targeting exosomal lncRNAs, proposing a new frontier in overcoming drug resistance. By mapping the interface of exosomal lncRNAs and drug resistance, this article aims to provide a comprehensive understanding that could pave the way for innovative treatments and improved patient outcomes in female reproductive system cancers.https://www.frontiersin.org/articles/10.3389/fcell.2025.1485422/fullexosomeslong non-coding RNAsdrug resistancefemale reproductive system cancerstumor microenvironmentchemotherapy efficacy |
| spellingShingle | Nooshafarin Shirani Neda Abdi Matin Chehelgerdi Matin Chehelgerdi Hajar Yaghoobi Mohammad Chehelgerdi Mohammad Chehelgerdi Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers Frontiers in Cell and Developmental Biology exosomes long non-coding RNAs drug resistance female reproductive system cancers tumor microenvironment chemotherapy efficacy |
| title | Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers |
| title_full | Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers |
| title_fullStr | Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers |
| title_full_unstemmed | Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers |
| title_short | Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers |
| title_sort | investigating the role of exosomal long non coding rnas in drug resistance within female reproductive system cancers |
| topic | exosomes long non-coding RNAs drug resistance female reproductive system cancers tumor microenvironment chemotherapy efficacy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1485422/full |
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