Miltefosine Rescue Treatment for Visceral Leishmaniasis Relapse Patient
We report the first case of miltefosine rescue treatment carried out for visceral leishmaniasis (VL) relapse patient. Despite undergoing treatment regimens of liposomal amphotericin B (LAMB) 5 mg/kg (standard: 10 mg/kg) daily for 3 days during the first episode followed by LAMB 5 mg/kg stat and paro...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2019/3634568 |
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| author | Anup Bastola Mitesh Shrestha Bimal Sharma Chalise Abhdesh Kumar Mishra Lina Devkota |
| author_facet | Anup Bastola Mitesh Shrestha Bimal Sharma Chalise Abhdesh Kumar Mishra Lina Devkota |
| author_sort | Anup Bastola |
| collection | DOAJ |
| description | We report the first case of miltefosine rescue treatment carried out for visceral leishmaniasis (VL) relapse patient. Despite undergoing treatment regimens of liposomal amphotericin B (LAMB) 5 mg/kg (standard: 10 mg/kg) daily for 3 days during the first episode followed by LAMB 5 mg/kg stat and paromomycin 15 mg/kg IM for 10 days against the second episode, the patient suffered from a third relapse and was eventually treated with miltefosine 50 mg BID directly observed treatment for 28 days. Prior to treatment, the patient had a history of intermittent fever and vague abdominal pain for one week and epistaxis for 4 days. He had massive splenomegaly, tested positive for the rK39 test, and showed LD bodies in bone marrow aspirate. The patient tested negative for malaria and HIV. Upon treatment completion with miltefosine, the patient had clinically improved and showed no LD bodies in bone marrow. |
| format | Article |
| id | doaj-art-570d0b1d07f44595b1d5ede21a30c675 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-570d0b1d07f44595b1d5ede21a30c6752025-02-03T01:11:04ZengWileyCase Reports in Infectious Diseases2090-66252090-66332019-01-01201910.1155/2019/36345683634568Miltefosine Rescue Treatment for Visceral Leishmaniasis Relapse PatientAnup Bastola0Mitesh Shrestha1Bimal Sharma Chalise2Abhdesh Kumar Mishra3Lina Devkota4Sukraraj Tropical & Infectious Disease Hospital, Kathmandu, NepalResearch Institute for Bioscience and Biotechnology, Kathmandu, NepalSukraraj Tropical & Infectious Disease Hospital, Kathmandu, NepalSukraraj Tropical & Infectious Disease Hospital, Kathmandu, NepalSukraraj Tropical & Infectious Disease Hospital, Kathmandu, NepalWe report the first case of miltefosine rescue treatment carried out for visceral leishmaniasis (VL) relapse patient. Despite undergoing treatment regimens of liposomal amphotericin B (LAMB) 5 mg/kg (standard: 10 mg/kg) daily for 3 days during the first episode followed by LAMB 5 mg/kg stat and paromomycin 15 mg/kg IM for 10 days against the second episode, the patient suffered from a third relapse and was eventually treated with miltefosine 50 mg BID directly observed treatment for 28 days. Prior to treatment, the patient had a history of intermittent fever and vague abdominal pain for one week and epistaxis for 4 days. He had massive splenomegaly, tested positive for the rK39 test, and showed LD bodies in bone marrow aspirate. The patient tested negative for malaria and HIV. Upon treatment completion with miltefosine, the patient had clinically improved and showed no LD bodies in bone marrow.http://dx.doi.org/10.1155/2019/3634568 |
| spellingShingle | Anup Bastola Mitesh Shrestha Bimal Sharma Chalise Abhdesh Kumar Mishra Lina Devkota Miltefosine Rescue Treatment for Visceral Leishmaniasis Relapse Patient Case Reports in Infectious Diseases |
| title | Miltefosine Rescue Treatment for Visceral Leishmaniasis Relapse Patient |
| title_full | Miltefosine Rescue Treatment for Visceral Leishmaniasis Relapse Patient |
| title_fullStr | Miltefosine Rescue Treatment for Visceral Leishmaniasis Relapse Patient |
| title_full_unstemmed | Miltefosine Rescue Treatment for Visceral Leishmaniasis Relapse Patient |
| title_short | Miltefosine Rescue Treatment for Visceral Leishmaniasis Relapse Patient |
| title_sort | miltefosine rescue treatment for visceral leishmaniasis relapse patient |
| url | http://dx.doi.org/10.1155/2019/3634568 |
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