Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks
Finding optimal policies to reduce the morbidity and mortality of the ongoing pandemic is a top public health priority. Using a compartmental model with age structure and vaccination status, we examined the effect of age specific scheduling of vaccination during a pandemic influenza outbreak, when t...
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| Format: | Article |
| Language: | English |
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AIMS Press
2010-12-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.123 |
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| author | Diána H. Knipl Gergely Röst |
| author_facet | Diána H. Knipl Gergely Röst |
| author_sort | Diána H. Knipl |
| collection | DOAJ |
| description | Finding optimal policies to reduce the morbidity and mortality of the ongoing pandemic is a top public health priority. Using a compartmental model with age structure and vaccination status, we examined the effect of age specific scheduling of vaccination during a pandemic influenza outbreak, when there is a race between the vaccination campaign and the dynamics of the pandemic. Our results agree with some recent studies on that age specificity is paramount to vaccination planning. However, little is known about the effectiveness of such control measures when they are applied during the outbreak. Comparing five possible strategies, we found that age specific scheduling can have a huge impact on the outcome of the epidemic. For the best scheme, the attack rateswere up to 10% lower than for other strategies. We demonstrate the importance of early start of the vaccination campaign, since ten days delay may increase the attack rate by up to 6%. Taking into account the delay between developing immunity and vaccination is a key factor in evaluating the impact of vaccination campaigns. We provide a general framework which will beuseful for the next pandemic waves as well. |
| format | Article |
| id | doaj-art-57098ee4e46c4a6aab5060010eb7258e |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2010-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-57098ee4e46c4a6aab5060010eb7258e2025-01-24T02:01:20ZengAIMS PressMathematical Biosciences and Engineering1551-00182010-12-018112313910.3934/mbe.2011.8.123Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaksDiána H. Knipl0Gergely Röst1Bolyai Institute, University of Szeged, H-6720 Szeged, Aradi vértanúk tere 1Bolyai Institute, University of Szeged, H-6720 Szeged, Aradi vértanúk tere 1Finding optimal policies to reduce the morbidity and mortality of the ongoing pandemic is a top public health priority. Using a compartmental model with age structure and vaccination status, we examined the effect of age specific scheduling of vaccination during a pandemic influenza outbreak, when there is a race between the vaccination campaign and the dynamics of the pandemic. Our results agree with some recent studies on that age specificity is paramount to vaccination planning. However, little is known about the effectiveness of such control measures when they are applied during the outbreak. Comparing five possible strategies, we found that age specific scheduling can have a huge impact on the outcome of the epidemic. For the best scheme, the attack rateswere up to 10% lower than for other strategies. We demonstrate the importance of early start of the vaccination campaign, since ten days delay may increase the attack rate by up to 6%. Taking into account the delay between developing immunity and vaccination is a key factor in evaluating the impact of vaccination campaigns. We provide a general framework which will beuseful for the next pandemic waves as well.https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.123compartmental modelpandemic influenzaa(h1n1)v.vaccination strategies |
| spellingShingle | Diána H. Knipl Gergely Röst Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks Mathematical Biosciences and Engineering compartmental model pandemic influenza a(h1n1)v. vaccination strategies |
| title | Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks |
| title_full | Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks |
| title_fullStr | Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks |
| title_full_unstemmed | Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks |
| title_short | Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks |
| title_sort | modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks |
| topic | compartmental model pandemic influenza a(h1n1)v. vaccination strategies |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.123 |
| work_keys_str_mv | AT dianahknipl modellingthestrategiesforagespecificvaccinationschedulingduringinfluenzapandemicoutbreaks AT gergelyrost modellingthestrategiesforagespecificvaccinationschedulingduringinfluenzapandemicoutbreaks |