Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study
Abstract Background and objective While the connection between the Triglyceride glucose-waist circumference (TyG-WC) index and the risk of diabetes remains understudied, this particular research delves into the potential predictive value of the TyG-WC index within a significant Japanese population....
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-025-01834-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585634891431936 |
|---|---|
| author | Yawei Li Linlin Shan Qiong Wen Changchun Cao Meiling Huang Chunxia Zhang Xiaoping Li Kun Wang Tianlun Zhou Fubing Zha Yulong Wang |
| author_facet | Yawei Li Linlin Shan Qiong Wen Changchun Cao Meiling Huang Chunxia Zhang Xiaoping Li Kun Wang Tianlun Zhou Fubing Zha Yulong Wang |
| author_sort | Yawei Li |
| collection | DOAJ |
| description | Abstract Background and objective While the connection between the Triglyceride glucose-waist circumference (TyG-WC) index and the risk of diabetes remains understudied, this particular research delves into the potential predictive value of the TyG-WC index within a significant Japanese population. Methods This retrospective cohort study encompassed a comprehensive analysis of 15,413 Japanese adults, all of whom were diabetes-free at the outset of the study period from 2004 to 2015. Comprehensive medical records were obtained for all participants who underwent physical examinations. The study employed Cox proportional-hazards regression, smooth curve fitting, various sensitivity, and subgroup analyses to explore the association between TyG-WC and the development of diabetes. Furthermore, a Receiver Operating Characteristic (ROC) curve was created to detect the predictive capability of TyG-WC for diabetes risk. Results After a maximum of 13.0 years of follow-up, 358 people finally developed diabetes. Upon adjusting for covariates, the result showed TyG-WC was positively and independently associated with incident Diabetes Mellitus (DM) (Hazard Ratio (HR): 1.004, 95%C: 1.001–1.006). Furthermore, ROC curve analysis demonstrated that TyG-WC outperformed both the triglycerides-glucose index and triglyceride glucose-body mass index in predicting the onset of diabetes. Conclusion High levels of TyG-WC are autonomously linked to a heightened risk of diabetes in the Japanese demographic, indicating its potential as a dependable predictive indicator for diabetes mellitus in individuals at elevated risk. |
| format | Article |
| id | doaj-art-5703924cf4c7421e991c500600c7f7cf |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-5703924cf4c7421e991c500600c7f7cf2025-01-26T12:37:38ZengBMCBMC Endocrine Disorders1472-68232025-01-0125111210.1186/s12902-025-01834-2Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort studyYawei Li0Linlin Shan1Qiong Wen2Changchun Cao3Meiling Huang4Chunxia Zhang5Xiaoping Li6Kun Wang7Tianlun Zhou8Fubing Zha9Yulong Wang10Department of Rehabilitation, Shenzhen Second People’s HospitalDepartment of Rehabilitation, Shenzhen Second People’s HospitalDepartment of Rehabilitation, Shenzhen Dapeng New District Nanao People’s HospitalDepartment of Rehabilitation, Shenzhen Dapeng New District Nanao People’s HospitalDepartment of Rehabilitation, Shenzhen Second People’s HospitalDepartment of Rehabilitation, Shenzhen Dapeng New District Nanao People’s HospitalDepartment of Rehabilitation, Shenzhen Second People’s HospitalDepartment of Rehabilitation, Shenzhen Second People’s HospitalDepartment of Rehabilitation, Shenzhen Second People’s HospitalDepartment of Rehabilitation, Shenzhen Second People’s HospitalDepartment of Rehabilitation, Shenzhen Second People’s HospitalAbstract Background and objective While the connection between the Triglyceride glucose-waist circumference (TyG-WC) index and the risk of diabetes remains understudied, this particular research delves into the potential predictive value of the TyG-WC index within a significant Japanese population. Methods This retrospective cohort study encompassed a comprehensive analysis of 15,413 Japanese adults, all of whom were diabetes-free at the outset of the study period from 2004 to 2015. Comprehensive medical records were obtained for all participants who underwent physical examinations. The study employed Cox proportional-hazards regression, smooth curve fitting, various sensitivity, and subgroup analyses to explore the association between TyG-WC and the development of diabetes. Furthermore, a Receiver Operating Characteristic (ROC) curve was created to detect the predictive capability of TyG-WC for diabetes risk. Results After a maximum of 13.0 years of follow-up, 358 people finally developed diabetes. Upon adjusting for covariates, the result showed TyG-WC was positively and independently associated with incident Diabetes Mellitus (DM) (Hazard Ratio (HR): 1.004, 95%C: 1.001–1.006). Furthermore, ROC curve analysis demonstrated that TyG-WC outperformed both the triglycerides-glucose index and triglyceride glucose-body mass index in predicting the onset of diabetes. Conclusion High levels of TyG-WC are autonomously linked to a heightened risk of diabetes in the Japanese demographic, indicating its potential as a dependable predictive indicator for diabetes mellitus in individuals at elevated risk.https://doi.org/10.1186/s12902-025-01834-2Triglyceride glucose-body mass indexTyG-WCIncident diabetes mellitusInsulin resistance |
| spellingShingle | Yawei Li Linlin Shan Qiong Wen Changchun Cao Meiling Huang Chunxia Zhang Xiaoping Li Kun Wang Tianlun Zhou Fubing Zha Yulong Wang Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study BMC Endocrine Disorders Triglyceride glucose-body mass index TyG-WC Incident diabetes mellitus Insulin resistance |
| title | Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study |
| title_full | Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study |
| title_fullStr | Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study |
| title_full_unstemmed | Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study |
| title_short | Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study |
| title_sort | triglyceride glucose waist circumference as a useful predictor for diabetes mellitus a secondary retrospective analysis utilizing a japanese cohort study |
| topic | Triglyceride glucose-body mass index TyG-WC Incident diabetes mellitus Insulin resistance |
| url | https://doi.org/10.1186/s12902-025-01834-2 |
| work_keys_str_mv | AT yaweili triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT linlinshan triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT qiongwen triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT changchuncao triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT meilinghuang triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT chunxiazhang triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT xiaopingli triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT kunwang triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT tianlunzhou triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT fubingzha triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy AT yulongwang triglycerideglucosewaistcircumferenceasausefulpredictorfordiabetesmellitusasecondaryretrospectiveanalysisutilizingajapanesecohortstudy |