Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma
Objectives. The aim of this study was to compare the creatinine equations with cystatin C (CysC) equations to define renal impairment (RI) in newly diagnosed multiple myeloma (MM) patients and to analyse the equation that allows for identifying patients with more and worse prognostic factors. Method...
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Wiley
2022-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/4282226 |
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| author | Francisco-Javier Cepeda-Piorno Esther González-García Alba Méndez-Gallego Juan Torres-Varona Vanesa García-Moreira Christian Sordo-Bahamonde Cristina AlberdiGarcía-del-Castillo Elene Astobieta-Madariaga Maria-Victoria Mateos-Manteca Segundo González-Rodríguez |
| author_facet | Francisco-Javier Cepeda-Piorno Esther González-García Alba Méndez-Gallego Juan Torres-Varona Vanesa García-Moreira Christian Sordo-Bahamonde Cristina AlberdiGarcía-del-Castillo Elene Astobieta-Madariaga Maria-Victoria Mateos-Manteca Segundo González-Rodríguez |
| author_sort | Francisco-Javier Cepeda-Piorno |
| collection | DOAJ |
| description | Objectives. The aim of this study was to compare the creatinine equations with cystatin C (CysC) equations to define renal impairment (RI) in newly diagnosed multiple myeloma (MM) patients and to analyse the equation that allows for identifying patients with more and worse prognostic factors. Methods. Renal function was evaluated prospectively in 61 patients with newly diagnosed untreated MM employing CKD-EPI and CAPA equations. The comparison was conducted using Bland–Altman graphics and Cohen’s Kappa statistic. Mann–Whitney T and Chi-square tests were used, and univariate and multivariate analyses were carried out. Results. According to the IMWG criteria, 26% of patients showed RI (3 women/13 men) whilst the use of CysC equations allowed us to identify up to 39% of patients (7 women/17 men). The CAPA equation was less biased and dispersed and more sensitive than CKD-EPI-creatinine. Furthermore, univariate analysis unveiled an association between decreased CKD-EPI-CysC and poor prognosis based on R-ISS-3. Conclusions. The IMWG criteria may underestimate kidney disease, mostly in women, which could affect the dose received as well as its toxicity. Altogether, our data suggest that equations that include CysC are more accurate to detect hidden kidney disease, as well as patients with more and worse prognostic factors, in newly diagnosed MM. |
| format | Article |
| id | doaj-art-57012ed325b64190a1ffc0b2709ee008 |
| institution | Kabale University |
| issn | 1687-9112 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-57012ed325b64190a1ffc0b2709ee0082025-02-03T01:23:38ZengWileyAdvances in Hematology1687-91122022-01-01202210.1155/2022/4282226Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple MyelomaFrancisco-Javier Cepeda-Piorno0Esther González-García1Alba Méndez-Gallego2Juan Torres-Varona3Vanesa García-Moreira4Christian Sordo-Bahamonde5Cristina AlberdiGarcía-del-Castillo6Elene Astobieta-Madariaga7Maria-Victoria Mateos-Manteca8Segundo González-Rodríguez9Servicio Análisis ClínicosServicio de HematologíaHospital Universitario de CabueñesHospital Universitario de CabueñesServicio de Análisis ClínicosISPAServicio de Análisis ClínicosServicio de Análisis ClínicosHospital Universitario de SalamancaISPAObjectives. The aim of this study was to compare the creatinine equations with cystatin C (CysC) equations to define renal impairment (RI) in newly diagnosed multiple myeloma (MM) patients and to analyse the equation that allows for identifying patients with more and worse prognostic factors. Methods. Renal function was evaluated prospectively in 61 patients with newly diagnosed untreated MM employing CKD-EPI and CAPA equations. The comparison was conducted using Bland–Altman graphics and Cohen’s Kappa statistic. Mann–Whitney T and Chi-square tests were used, and univariate and multivariate analyses were carried out. Results. According to the IMWG criteria, 26% of patients showed RI (3 women/13 men) whilst the use of CysC equations allowed us to identify up to 39% of patients (7 women/17 men). The CAPA equation was less biased and dispersed and more sensitive than CKD-EPI-creatinine. Furthermore, univariate analysis unveiled an association between decreased CKD-EPI-CysC and poor prognosis based on R-ISS-3. Conclusions. The IMWG criteria may underestimate kidney disease, mostly in women, which could affect the dose received as well as its toxicity. Altogether, our data suggest that equations that include CysC are more accurate to detect hidden kidney disease, as well as patients with more and worse prognostic factors, in newly diagnosed MM.http://dx.doi.org/10.1155/2022/4282226 |
| spellingShingle | Francisco-Javier Cepeda-Piorno Esther González-García Alba Méndez-Gallego Juan Torres-Varona Vanesa García-Moreira Christian Sordo-Bahamonde Cristina AlberdiGarcía-del-Castillo Elene Astobieta-Madariaga Maria-Victoria Mateos-Manteca Segundo González-Rodríguez Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma Advances in Hematology |
| title | Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma |
| title_full | Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma |
| title_fullStr | Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma |
| title_full_unstemmed | Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma |
| title_short | Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma |
| title_sort | cystatin c based equations detect hidden kidney disease and poor prognosis in newly diagnosed patients with multiple myeloma |
| url | http://dx.doi.org/10.1155/2022/4282226 |
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