Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs). Disruption of these synapses not only disables the...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/6143164 |
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| author | Lijuan Shi Ying Chang Xiaowei Li Steve Aiken Lijie Liu Jian Wang |
| author_facet | Lijuan Shi Ying Chang Xiaowei Li Steve Aiken Lijie Liu Jian Wang |
| author_sort | Lijuan Shi |
| collection | DOAJ |
| description | Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs). Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synapses are not reestablished. Such a loss of ANFs should result in signal coding deficits, which are exacerbated by the bias of the damage toward synapses connecting low-spontaneous-rate (SR) ANFs, which are known to be vital for signal coding in noisy background. As there is no PTS, these functional deficits cannot be detected using routine audiological evaluations and may be unknown to subjects who have them. Such functional deficits in hearing without changes in sensitivity are generally called “noise-induced hidden hearing loss (NIHHL).” Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL. |
| format | Article |
| id | doaj-art-56f5bae7bd26414b93f41443e1e983d9 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-56f5bae7bd26414b93f41443e1e983d92025-02-03T01:01:07ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/61431646143164Cochlear Synaptopathy and Noise-Induced Hidden Hearing LossLijuan Shi0Ying Chang1Xiaowei Li2Steve Aiken3Lijie Liu4Jian Wang5Department of Physiology, Medical College of Southeast University, 87 Dingjiaoqiao Road, Nanjing 210009, ChinaDepartment of Physiology, Medical College of Southeast University, 87 Dingjiaoqiao Road, Nanjing 210009, ChinaDepartment of Physiology, Medical College of Southeast University, 87 Dingjiaoqiao Road, Nanjing 210009, ChinaSchool of Human Communication Disorders, Dalhousie University, 1256 Barrington St. Dalhousie University, Halifax, NS, B3J 1Y6, CanadaDepartment of Physiology, Medical College of Southeast University, 87 Dingjiaoqiao Road, Nanjing 210009, ChinaDepartment of Physiology, Medical College of Southeast University, 87 Dingjiaoqiao Road, Nanjing 210009, ChinaRecent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs). Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synapses are not reestablished. Such a loss of ANFs should result in signal coding deficits, which are exacerbated by the bias of the damage toward synapses connecting low-spontaneous-rate (SR) ANFs, which are known to be vital for signal coding in noisy background. As there is no PTS, these functional deficits cannot be detected using routine audiological evaluations and may be unknown to subjects who have them. Such functional deficits in hearing without changes in sensitivity are generally called “noise-induced hidden hearing loss (NIHHL).” Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL.http://dx.doi.org/10.1155/2016/6143164 |
| spellingShingle | Lijuan Shi Ying Chang Xiaowei Li Steve Aiken Lijie Liu Jian Wang Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss Neural Plasticity |
| title | Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss |
| title_full | Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss |
| title_fullStr | Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss |
| title_full_unstemmed | Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss |
| title_short | Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss |
| title_sort | cochlear synaptopathy and noise induced hidden hearing loss |
| url | http://dx.doi.org/10.1155/2016/6143164 |
| work_keys_str_mv | AT lijuanshi cochlearsynaptopathyandnoiseinducedhiddenhearingloss AT yingchang cochlearsynaptopathyandnoiseinducedhiddenhearingloss AT xiaoweili cochlearsynaptopathyandnoiseinducedhiddenhearingloss AT steveaiken cochlearsynaptopathyandnoiseinducedhiddenhearingloss AT lijieliu cochlearsynaptopathyandnoiseinducedhiddenhearingloss AT jianwang cochlearsynaptopathyandnoiseinducedhiddenhearingloss |