Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit
Enteral nutrition (EN) formulas are necessary for critically ill patients to meet their metabolic requirements. Polyamines (putrescine, spermidine, and spermine) are crucial dietary components, with spermidine being particularly interesting due to its multiple proposed benefits. The requirements for...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/15/2/659 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589259449565184 |
|---|---|
| author | Manuel Sánchez Eva Rodríguez-Hernández Lorena Suárez Begoña Cantabrana María González-García |
| author_facet | Manuel Sánchez Eva Rodríguez-Hernández Lorena Suárez Begoña Cantabrana María González-García |
| author_sort | Manuel Sánchez |
| collection | DOAJ |
| description | Enteral nutrition (EN) formulas are necessary for critically ill patients to meet their metabolic requirements. Polyamines (putrescine, spermidine, and spermine) are crucial dietary components, with spermidine being particularly interesting due to its multiple proposed benefits. The requirements for and intake of polyamines have yet to be investigated in adult patients hospitalised in intensive care units (ICUs) who are exclusively fed via commercial EN formulas. The aim of this study was to determine the polyamine content and other biogenic amines of EN formulas and the total intake and gastric residual volume (GRV) in adult ICU patients during their first seven days of hospitalisation. The amines were analysed in 16 EN formulas using high-performance liquid chromatography (HPLC). The clinical data of eight patients of both sexes aged 47 to 77 admitted to the ICU were analysed. Differences existed among the analysed EN formulas. The <i>N</i>-acetyl putrescine content was higher than that of the remaining amines. The daily intake of polyamines in the ICU was less than 100 μmol (the dietary intake is above 400 μmol). An inverse correlation existed between total daily polyamine intake and daily GRV, without effects from other biogenic amines being analysed. Polyamine intake in critically ill patients receiving EN is low and could impact these patients’ feeding tolerance. These findings underscore the need for further research to explore the clinical implications of increasing the polyamine content of EN formulas. |
| format | Article |
| id | doaj-art-56dcbff928b9433e83c13e4f38637f65 |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-56dcbff928b9433e83c13e4f38637f652025-01-24T13:20:19ZengMDPI AGApplied Sciences2076-34172025-01-0115265910.3390/app15020659Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care UnitManuel Sánchez0Eva Rodríguez-Hernández1Lorena Suárez2Begoña Cantabrana3María González-García4Farmacología, Departamento de Medicina, Universidad de Oviedo, 33006 Oviedo, SpainFarmacología, Departamento de Medicina, Universidad de Oviedo, 33006 Oviedo, SpainFarmacología, Departamento de Medicina, Universidad de Oviedo, 33006 Oviedo, SpainFarmacología, Departamento de Medicina, Universidad de Oviedo, 33006 Oviedo, SpainUnidad de Cuidados Intensivos, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, SpainEnteral nutrition (EN) formulas are necessary for critically ill patients to meet their metabolic requirements. Polyamines (putrescine, spermidine, and spermine) are crucial dietary components, with spermidine being particularly interesting due to its multiple proposed benefits. The requirements for and intake of polyamines have yet to be investigated in adult patients hospitalised in intensive care units (ICUs) who are exclusively fed via commercial EN formulas. The aim of this study was to determine the polyamine content and other biogenic amines of EN formulas and the total intake and gastric residual volume (GRV) in adult ICU patients during their first seven days of hospitalisation. The amines were analysed in 16 EN formulas using high-performance liquid chromatography (HPLC). The clinical data of eight patients of both sexes aged 47 to 77 admitted to the ICU were analysed. Differences existed among the analysed EN formulas. The <i>N</i>-acetyl putrescine content was higher than that of the remaining amines. The daily intake of polyamines in the ICU was less than 100 μmol (the dietary intake is above 400 μmol). An inverse correlation existed between total daily polyamine intake and daily GRV, without effects from other biogenic amines being analysed. Polyamine intake in critically ill patients receiving EN is low and could impact these patients’ feeding tolerance. These findings underscore the need for further research to explore the clinical implications of increasing the polyamine content of EN formulas.https://www.mdpi.com/2076-3417/15/2/659polyaminesputrescinespermidinespermineenteral nutrition formulapolyamine intake |
| spellingShingle | Manuel Sánchez Eva Rodríguez-Hernández Lorena Suárez Begoña Cantabrana María González-García Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit Applied Sciences polyamines putrescine spermidine spermine enteral nutrition formula polyamine intake |
| title | Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit |
| title_full | Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit |
| title_fullStr | Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit |
| title_full_unstemmed | Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit |
| title_short | Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit |
| title_sort | polyamine content of enteral nutrition formulas effect of daily intake on the feeding tolerance of patients during the first week in the intensive care unit |
| topic | polyamines putrescine spermidine spermine enteral nutrition formula polyamine intake |
| url | https://www.mdpi.com/2076-3417/15/2/659 |
| work_keys_str_mv | AT manuelsanchez polyaminecontentofenteralnutritionformulaseffectofdailyintakeonthefeedingtoleranceofpatientsduringthefirstweekintheintensivecareunit AT evarodriguezhernandez polyaminecontentofenteralnutritionformulaseffectofdailyintakeonthefeedingtoleranceofpatientsduringthefirstweekintheintensivecareunit AT lorenasuarez polyaminecontentofenteralnutritionformulaseffectofdailyintakeonthefeedingtoleranceofpatientsduringthefirstweekintheintensivecareunit AT begonacantabrana polyaminecontentofenteralnutritionformulaseffectofdailyintakeonthefeedingtoleranceofpatientsduringthefirstweekintheintensivecareunit AT mariagonzalezgarcia polyaminecontentofenteralnutritionformulaseffectofdailyintakeonthefeedingtoleranceofpatientsduringthefirstweekintheintensivecareunit |