RNA modifications: emerging players in the regulation of reproduction and development
The intricate world of RNA modifications, collectively termed the epitranscriptome, covers over 170 identified modifications and impacts RNA metabolism and, consequently, almost all biological processes. In this review, we focus on the regu...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
China Science Publishing & Media Ltd.
2024-11-01
|
| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024201 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590327538515968 |
|---|---|
| author | Wen Junfei Zhu Qifan Liu Yong Gou Lan-Tao |
| author_facet | Wen Junfei Zhu Qifan Liu Yong Gou Lan-Tao |
| author_sort | Wen Junfei |
| collection | DOAJ |
| description | The intricate world of RNA modifications, collectively termed the epitranscriptome, covers over 170 identified modifications and impacts RNA metabolism and, consequently, almost all biological processes. In this review, we focus on the regulatory roles and biological functions of a panel of dominant RNA modifications (including m<sup>6</sup>A, m<sup>5</sup>C, Ψ, ac<sup>4</sup>C, m<sup>1</sup>A, and m<sup>7</sup>G) on three RNA types—mRNA, tRNA, and rRNA—in mammalian development, particularly in the context of reproduction as well as embryonic development. We discuss in detail how those modifications, along with their regulatory proteins, affect RNA processing, structure, localization, stability, and translation efficiency. We also highlight the associations among dysfunctions in RNA modification-related proteins, abnormal modification deposition and various diseases, emphasizing the roles of RNA modifications in critical developmental processes such as stem cell self-renewal and cell fate transition. Elucidating the molecular mechanisms by which RNA modifications influence diverse developmental processes holds promise for developing innovative strategies to manage developmental disorders. Finally, we outline several unexplored areas in the field of RNA modification that warrant further investigation. |
| format | Article |
| id | doaj-art-56dbf07698e7417bbb7bbd40fc3c3b3c |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-56dbf07698e7417bbb7bbd40fc3c3b3c2025-01-24T00:56:47ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-11-0157335810.3724/abbs.202420120d259ccRNA modifications: emerging players in the regulation of reproduction and developmentWen Junfei0Zhu Qifan1Liu Yong2Gou Lan-Tao3["Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China","University of Chinese Academy of Sciences, Beijing 100049, China"]["Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China","University of Chinese Academy of Sciences, Beijing 100049, China"]["Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China"]["Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China","University of Chinese Academy of Sciences, Beijing 100049, China"]The intricate world of RNA modifications, collectively termed the epitranscriptome, covers over 170 identified modifications and impacts RNA metabolism and, consequently, almost all biological processes. In this review, we focus on the regulatory roles and biological functions of a panel of dominant RNA modifications (including m<sup>6</sup>A, m<sup>5</sup>C, Ψ, ac<sup>4</sup>C, m<sup>1</sup>A, and m<sup>7</sup>G) on three RNA types—mRNA, tRNA, and rRNA—in mammalian development, particularly in the context of reproduction as well as embryonic development. We discuss in detail how those modifications, along with their regulatory proteins, affect RNA processing, structure, localization, stability, and translation efficiency. We also highlight the associations among dysfunctions in RNA modification-related proteins, abnormal modification deposition and various diseases, emphasizing the roles of RNA modifications in critical developmental processes such as stem cell self-renewal and cell fate transition. Elucidating the molecular mechanisms by which RNA modifications influence diverse developmental processes holds promise for developing innovative strategies to manage developmental disorders. Finally, we outline several unexplored areas in the field of RNA modification that warrant further investigation.https://www.sciengine.com/doi/10.3724/abbs.2024201RNA modificationreproductionepitranscriptomicmammalian developmentdevelopmental disease |
| spellingShingle | Wen Junfei Zhu Qifan Liu Yong Gou Lan-Tao RNA modifications: emerging players in the regulation of reproduction and development Acta Biochimica et Biophysica Sinica RNA modification reproduction epitranscriptomic mammalian development developmental disease |
| title | RNA modifications: emerging players in the regulation of reproduction and development |
| title_full | RNA modifications: emerging players in the regulation of reproduction and development |
| title_fullStr | RNA modifications: emerging players in the regulation of reproduction and development |
| title_full_unstemmed | RNA modifications: emerging players in the regulation of reproduction and development |
| title_short | RNA modifications: emerging players in the regulation of reproduction and development |
| title_sort | rna modifications emerging players in the regulation of reproduction and development |
| topic | RNA modification reproduction epitranscriptomic mammalian development developmental disease |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024201 |
| work_keys_str_mv | AT wenjunfei rnamodificationsemergingplayersintheregulationofreproductionanddevelopment AT zhuqifan rnamodificationsemergingplayersintheregulationofreproductionanddevelopment AT liuyong rnamodificationsemergingplayersintheregulationofreproductionanddevelopment AT goulantao rnamodificationsemergingplayersintheregulationofreproductionanddevelopment |