A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adapt...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9483433 |
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| author | Seema Dubey Manohar Singh Ariel Nelson Dev Karan |
| author_facet | Seema Dubey Manohar Singh Ariel Nelson Dev Karan |
| author_sort | Seema Dubey |
| collection | DOAJ |
| description | Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substances competent to inhibit or reverse the process of carcinogenesis. The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. This article signifies the cumulative information about the role of WFA in modulating antitumor immunity and its potential in targeting prostate cancer. |
| format | Article |
| id | doaj-art-56d6533774cd48b4a140eaaeb9dc05ec |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-56d6533774cd48b4a140eaaeb9dc05ec2025-02-03T05:44:09ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/94834339483433A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate CancerSeema Dubey0Manohar Singh1Ariel Nelson2Dev Karan3Department of Pathology, MCW Cancer Center and Prostate Cancer Center of Excellence, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USADepartment of Pathology, MCW Cancer Center and Prostate Cancer Center of Excellence, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USADepartment of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USADepartment of Pathology, MCW Cancer Center and Prostate Cancer Center of Excellence, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USAMedicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substances competent to inhibit or reverse the process of carcinogenesis. The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. This article signifies the cumulative information about the role of WFA in modulating antitumor immunity and its potential in targeting prostate cancer.http://dx.doi.org/10.1155/2021/9483433 |
| spellingShingle | Seema Dubey Manohar Singh Ariel Nelson Dev Karan A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer Journal of Immunology Research |
| title | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
| title_full | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
| title_fullStr | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
| title_full_unstemmed | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
| title_short | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
| title_sort | perspective on withania somnifera modulating antitumor immunity in targeting prostate cancer |
| url | http://dx.doi.org/10.1155/2021/9483433 |
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