Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil
Opuntia dillenii (Ker-Gawl.) Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2020/5717052 |
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| author | Mohamed Bouhrim Nour Elhouda Daoudi Hayat Ouassou Amina Benoutman El Hassania Loukili Abderrahim Ziyyat Hassane Mekhfi Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham |
| author_facet | Mohamed Bouhrim Nour Elhouda Daoudi Hayat Ouassou Amina Benoutman El Hassania Loukili Abderrahim Ziyyat Hassane Mekhfi Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham |
| author_sort | Mohamed Bouhrim |
| collection | DOAJ |
| description | Opuntia dillenii (Ker-Gawl.) Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of O. dillenii seeds oil (ODSO), in vivo. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the Folin–Ciocalteu method were applied in this study to determine antioxidant activity and total phenolic content of ODSO, respectively. The antihyperlipidemic effect of the ODSO (2 ml/kg) was evaluated in the high-fat diet-fed albino mice, relying on lipid profile, blood glucose, and growth performance variations. Moreover, the preventive effect of ODSO was evaluated against alloxan monohydrate-induced diabetes in albino mice. ODSO had the highest total phenolic content (518.18 ± 14.36 mg EAC/kg) and DPPH scavenging activity (IC50 = 0.38 ± 0.08 mg/mL). Furthermore, ODSO showed a significant antidiabetogenic effect by reducing bodyweight loss, blood sugar level rise, and mortality rate caused by alloxan in albino mice. Then, ODSO has exhibited a significant antihyperlipidemic effect by improving the lipid profile disorder and glucose level rise in the blood, produced by the high-fat diet-fed albino mice. Results suggest that antidiabetogenic and antihyperlipidemic activities of ODSO correlate to the phenolic content and antioxidant activity of this oil. Hence, this plant could be a significant source of medically important critical compounds. |
| format | Article |
| id | doaj-art-56bd5ff28e824ea3a7d131c06471ee26 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-56bd5ff28e824ea3a7d131c06471ee262025-02-03T00:58:53ZengWileyThe Scientific World Journal2356-61401537-744X2020-01-01202010.1155/2020/57170525717052Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed OilMohamed Bouhrim0Nour Elhouda Daoudi1Hayat Ouassou2Amina Benoutman3El Hassania Loukili4Abderrahim Ziyyat5Hassane Mekhfi6Abdelkhaleq Legssyer7Mohammed Aziz8Mohamed Bnouham9Laboratory of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences, University Mohamed First, Oujda, MoroccoLaboratory of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences, University Mohamed First, Oujda, MoroccoLaboratory of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences, University Mohamed First, Oujda, MoroccoLaboratory of Biology, Environment, and Sustainable Development, Higher Normal School, Abdelmalek Essaadi University, Tetouan, MoroccoLaboratory of Applied Analytical Chemistry, Materials and Environment, Department of Chemistry, Faculty of Sciences, Mohammed First University, Oujda, MoroccoLaboratory of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences, University Mohamed First, Oujda, MoroccoLaboratory of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences, University Mohamed First, Oujda, MoroccoLaboratory of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences, University Mohamed First, Oujda, MoroccoLaboratory of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences, University Mohamed First, Oujda, MoroccoLaboratory of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences, University Mohamed First, Oujda, MoroccoOpuntia dillenii (Ker-Gawl.) Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of O. dillenii seeds oil (ODSO), in vivo. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the Folin–Ciocalteu method were applied in this study to determine antioxidant activity and total phenolic content of ODSO, respectively. The antihyperlipidemic effect of the ODSO (2 ml/kg) was evaluated in the high-fat diet-fed albino mice, relying on lipid profile, blood glucose, and growth performance variations. Moreover, the preventive effect of ODSO was evaluated against alloxan monohydrate-induced diabetes in albino mice. ODSO had the highest total phenolic content (518.18 ± 14.36 mg EAC/kg) and DPPH scavenging activity (IC50 = 0.38 ± 0.08 mg/mL). Furthermore, ODSO showed a significant antidiabetogenic effect by reducing bodyweight loss, blood sugar level rise, and mortality rate caused by alloxan in albino mice. Then, ODSO has exhibited a significant antihyperlipidemic effect by improving the lipid profile disorder and glucose level rise in the blood, produced by the high-fat diet-fed albino mice. Results suggest that antidiabetogenic and antihyperlipidemic activities of ODSO correlate to the phenolic content and antioxidant activity of this oil. Hence, this plant could be a significant source of medically important critical compounds.http://dx.doi.org/10.1155/2020/5717052 |
| spellingShingle | Mohamed Bouhrim Nour Elhouda Daoudi Hayat Ouassou Amina Benoutman El Hassania Loukili Abderrahim Ziyyat Hassane Mekhfi Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil The Scientific World Journal |
| title | Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil |
| title_full | Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil |
| title_fullStr | Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil |
| title_full_unstemmed | Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil |
| title_short | Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil |
| title_sort | phenolic content and antioxidant antihyperlipidemic and antidiabetogenic effects of opuntia dillenii seed oil |
| url | http://dx.doi.org/10.1155/2020/5717052 |
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