Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain?
Abstract Cancer is a major public health issue, with an estimated 20 million new cases and 9.7 million cancer-related deaths worldwide in 2022. Approximately 44.5% of patients experience cancer pain, significantly impacting their quality of life and causing physical and psychological burdens. Repeti...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-11-01
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| Series: | Pain and Therapy |
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| Online Access: | https://doi.org/10.1007/s40122-024-00679-2 |
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| author | Yanyuan Du Yaoyuan Li Jieqing Hu Ruiying Fang Yuming Liu Liu Cai Ying Song Susu Ma Jin Gao Hanyue Zhang Baihui Li Hongtai Xiong Huibo Yu Shenglei Yang Shuduo Zhu Honggang Zheng |
| author_facet | Yanyuan Du Yaoyuan Li Jieqing Hu Ruiying Fang Yuming Liu Liu Cai Ying Song Susu Ma Jin Gao Hanyue Zhang Baihui Li Hongtai Xiong Huibo Yu Shenglei Yang Shuduo Zhu Honggang Zheng |
| author_sort | Yanyuan Du |
| collection | DOAJ |
| description | Abstract Cancer is a major public health issue, with an estimated 20 million new cases and 9.7 million cancer-related deaths worldwide in 2022. Approximately 44.5% of patients experience cancer pain, significantly impacting their quality of life and causing physical and psychological burdens. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique, shows potential in managing cancer pain. This review summarizes current research on rTMS for cancer pain, focusing on pain directly caused by tumors, pain from cancer treatments, postoperative pain, and cancer-related symptoms. Additionally, rTMS shows promise in improving cancer-related fatigue, anxiety, depression, and cognitive dysfunction, which can indirectly reduce cancer pain. The analgesic mechanisms of rTMS include inhibiting nociceptive signal transmission in the spinal cord, modulating hemodynamic changes in brain regions, and promoting endogenous opioid release. High-frequency stimulation of the primary motor cortex (M1) has shown significant analgesic effects, improving patients' emotional and cognitive functions and overall quality of life. rTMS has a favorable safety profile, with most studies reporting no severe adverse events. In conclusion, rTMS holds substantial potential for cancer pain management, offering a non-invasive and multifaceted therapeutic approach. Continued research and clinical application are expected to establish rTMS as an essential component of comprehensive cancer pain treatment strategies, significantly enhancing the overall well-being of patients with cancer. |
| format | Article |
| id | doaj-art-56a2178e150445e396526c5ea7236016 |
| institution | Kabale University |
| issn | 2193-8237 2193-651X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Pain and Therapy |
| spelling | doaj-art-56a2178e150445e396526c5ea72360162025-01-26T12:14:03ZengAdis, Springer HealthcarePain and Therapy2193-82372193-651X2024-11-01141476610.1007/s40122-024-00679-2Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain?Yanyuan Du0Yaoyuan Li1Jieqing Hu2Ruiying Fang3Yuming Liu4Liu Cai5Ying Song6Susu Ma7Jin Gao8Hanyue Zhang9Baihui Li10Hongtai Xiong11Huibo Yu12Shenglei Yang13Shuduo Zhu14Honggang Zheng15Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Rehabilitation Medicine, Guang’anmen Hospital, China Academy of Chinese Medical SciencesFengtai Community Health Service CenterDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesSchool of Sports Medicine and Rehabilitation, Beijing Sport UniversityBinzhou People’s HospitalDepartment of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesAbstract Cancer is a major public health issue, with an estimated 20 million new cases and 9.7 million cancer-related deaths worldwide in 2022. Approximately 44.5% of patients experience cancer pain, significantly impacting their quality of life and causing physical and psychological burdens. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique, shows potential in managing cancer pain. This review summarizes current research on rTMS for cancer pain, focusing on pain directly caused by tumors, pain from cancer treatments, postoperative pain, and cancer-related symptoms. Additionally, rTMS shows promise in improving cancer-related fatigue, anxiety, depression, and cognitive dysfunction, which can indirectly reduce cancer pain. The analgesic mechanisms of rTMS include inhibiting nociceptive signal transmission in the spinal cord, modulating hemodynamic changes in brain regions, and promoting endogenous opioid release. High-frequency stimulation of the primary motor cortex (M1) has shown significant analgesic effects, improving patients' emotional and cognitive functions and overall quality of life. rTMS has a favorable safety profile, with most studies reporting no severe adverse events. In conclusion, rTMS holds substantial potential for cancer pain management, offering a non-invasive and multifaceted therapeutic approach. Continued research and clinical application are expected to establish rTMS as an essential component of comprehensive cancer pain treatment strategies, significantly enhancing the overall well-being of patients with cancer.https://doi.org/10.1007/s40122-024-00679-2Cancer painRepetitive transcranial magnetic stimulation (rTMS)NeuroplasticityPain management |
| spellingShingle | Yanyuan Du Yaoyuan Li Jieqing Hu Ruiying Fang Yuming Liu Liu Cai Ying Song Susu Ma Jin Gao Hanyue Zhang Baihui Li Hongtai Xiong Huibo Yu Shenglei Yang Shuduo Zhu Honggang Zheng Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? Pain and Therapy Cancer pain Repetitive transcranial magnetic stimulation (rTMS) Neuroplasticity Pain management |
| title | Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? |
| title_full | Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? |
| title_fullStr | Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? |
| title_full_unstemmed | Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? |
| title_short | Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain? |
| title_sort | repetitive transcranial magnetic stimulation is it an effective treatment for cancer pain |
| topic | Cancer pain Repetitive transcranial magnetic stimulation (rTMS) Neuroplasticity Pain management |
| url | https://doi.org/10.1007/s40122-024-00679-2 |
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