Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease
Background. The role of inflammatory and angiogenic cytokines in patients with inflammatory pericardial effusion still remains uncertain. Methods. We assessed pericardial and serum levels of VEGF, bFGF, IL-1β and TNF-α by ELISA in patients with inflammatory pericardial effusion (PE) of autoreactive...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/382082 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567230545526784 |
|---|---|
| author | Konstantinos Karatolios Rainer Moosdorf Bernhard Maisch Sabine Pankuweit |
| author_facet | Konstantinos Karatolios Rainer Moosdorf Bernhard Maisch Sabine Pankuweit |
| author_sort | Konstantinos Karatolios |
| collection | DOAJ |
| description | Background. The role of inflammatory and angiogenic cytokines in patients with inflammatory pericardial effusion still remains uncertain. Methods. We assessed pericardial and serum levels of VEGF, bFGF, IL-1β and TNF-α by ELISA in patients with inflammatory pericardial effusion (PE) of autoreactive (𝑛=22) and viral (𝑛=11) origin, and for control in pericardial fluid (PF) and serum (𝑛=26) of patients with coronary artery disease (CAD) undergoing coronary artery bypass graft surgery. Results. VEGF levels were significantly higher in patients with autoreactive and viral PE than in patients with CAD in both PE (𝑃=0,006 for autoreactive and 𝑃<0,001 for viral PE) and serum (𝑃<0,001 for autoreactive and 𝑃<0,001 for viral PE). Pericardial bFGF levels were higher compared to serum levels in patients with inflammatory PE and patients with CAD (𝑃≤0,001 for CAD; 𝑃≤0,001 for autoreactive PE; 𝑃=0,005 for viral PE). Pericardial VEGF levels correlated positively with markers of pericardial inflammation, whereas pericardial bFGF levels showed a negative correlation. IL-1β and TNF-α were detectable only in few PE and serum samples. Conclusions. VEGF and bFGF levels in pericardial effusion are elevated in patients with inflammatory PE. It is thus possible that VEGF and bFGF participate in the pathogenesis of inflammatory pericardial disease. |
| format | Article |
| id | doaj-art-5696bc664ba54281ac2be8735e852408 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5696bc664ba54281ac2be8735e8524082025-02-03T01:01:58ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/382082382082Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial DiseaseKonstantinos Karatolios0Rainer Moosdorf1Bernhard Maisch2Sabine Pankuweit3Department of Cardiology, University Hospital Gießen & Marburg, Baldinger Straße, 35043 Marburg, GermanyDepartment of Heart Surgery, University Hospital Gießen & Marburg, Baldinger Straße, 35043 Marburg, GermanyDepartment of Cardiology, University Hospital Gießen & Marburg, Baldinger Straße, 35043 Marburg, GermanyDepartment of Cardiology, University Hospital Gießen & Marburg, Baldinger Straße, 35043 Marburg, GermanyBackground. The role of inflammatory and angiogenic cytokines in patients with inflammatory pericardial effusion still remains uncertain. Methods. We assessed pericardial and serum levels of VEGF, bFGF, IL-1β and TNF-α by ELISA in patients with inflammatory pericardial effusion (PE) of autoreactive (𝑛=22) and viral (𝑛=11) origin, and for control in pericardial fluid (PF) and serum (𝑛=26) of patients with coronary artery disease (CAD) undergoing coronary artery bypass graft surgery. Results. VEGF levels were significantly higher in patients with autoreactive and viral PE than in patients with CAD in both PE (𝑃=0,006 for autoreactive and 𝑃<0,001 for viral PE) and serum (𝑃<0,001 for autoreactive and 𝑃<0,001 for viral PE). Pericardial bFGF levels were higher compared to serum levels in patients with inflammatory PE and patients with CAD (𝑃≤0,001 for CAD; 𝑃≤0,001 for autoreactive PE; 𝑃=0,005 for viral PE). Pericardial VEGF levels correlated positively with markers of pericardial inflammation, whereas pericardial bFGF levels showed a negative correlation. IL-1β and TNF-α were detectable only in few PE and serum samples. Conclusions. VEGF and bFGF levels in pericardial effusion are elevated in patients with inflammatory PE. It is thus possible that VEGF and bFGF participate in the pathogenesis of inflammatory pericardial disease.http://dx.doi.org/10.1155/2012/382082 |
| spellingShingle | Konstantinos Karatolios Rainer Moosdorf Bernhard Maisch Sabine Pankuweit Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease Mediators of Inflammation |
| title | Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease |
| title_full | Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease |
| title_fullStr | Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease |
| title_full_unstemmed | Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease |
| title_short | Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease |
| title_sort | cytokines in pericardial effusion of patients with inflammatory pericardial disease |
| url | http://dx.doi.org/10.1155/2012/382082 |
| work_keys_str_mv | AT konstantinoskaratolios cytokinesinpericardialeffusionofpatientswithinflammatorypericardialdisease AT rainermoosdorf cytokinesinpericardialeffusionofpatientswithinflammatorypericardialdisease AT bernhardmaisch cytokinesinpericardialeffusionofpatientswithinflammatorypericardialdisease AT sabinepankuweit cytokinesinpericardialeffusionofpatientswithinflammatorypericardialdisease |