The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study
Abstract Purpose This retrospective single-center study aimed to determine the correlation between The Paris System (TPS) urine cytology classification, cystoscopy findings, and non-muscle-invasive bladder cancer diagnosis. In addition, we sought to identify factors that might explain the abnormal c...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01828-5 |
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| author | Perttu Saarinen Otto Jokelainen Liida Ruotsalainen Essi Ikonen Timo K. Nykopp |
| author_facet | Perttu Saarinen Otto Jokelainen Liida Ruotsalainen Essi Ikonen Timo K. Nykopp |
| author_sort | Perttu Saarinen |
| collection | DOAJ |
| description | Abstract Purpose This retrospective single-center study aimed to determine the correlation between The Paris System (TPS) urine cytology classification, cystoscopy findings, and non-muscle-invasive bladder cancer diagnosis. In addition, we sought to identify factors that might explain the abnormal cytology classification in cases in which no malignancy was detected. Methods A Total of 855 patients evaluated with urine cytology between 2017 and 2020 at Kuopio University Hospital were included. Histological diagnoses and urinalysis results were correlated with cytology (TPS). Chi-squared and Fisher’s exact tests were used to calculate statistical significance. Results In the absence of exophytic tumors on cystoscopy, the risks of bladder cancer was 0.1% for NHGUC, 1.5% for AUC, 22.7% for SHGUC, and 83.3% for HGUC. Positive urinalysis corresponded to lower cytological diagnostic categories in both males and females. A statistically significant difference was observed in males with respect to moderate pyuria, hematuria, and higher cytological categories. Conclusions This study provides evidence that a biopsy or follow-up may not be necessary for patients without a prior history of urothelial carcinoma and without exophytic tumors observed on cystoscopy, when the cytological diagnosis is NHGUC or AUC. Furthermore, concurrent hematuria and pyuria may result in a higher cytological classification. |
| format | Article |
| id | doaj-art-568a63865a4345b3b678192d074b452f |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-568a63865a4345b3b678192d074b452f2025-02-02T12:30:27ZengSpringerDiscover Oncology2730-60112025-01-011611810.1007/s12672-025-01828-5The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center studyPerttu Saarinen0Otto Jokelainen1Liida Ruotsalainen2Essi Ikonen3Timo K. Nykopp4Institute of Clinical Medicine, University of Eastern FinlandInstitute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern FinlandInstitute of Clinical Medicine, University of Eastern FinlandDepartment of Clinical Pathology, Kuopio University HospitalInstitute of Clinical Medicine, Surgery, University of Eastern FinlandAbstract Purpose This retrospective single-center study aimed to determine the correlation between The Paris System (TPS) urine cytology classification, cystoscopy findings, and non-muscle-invasive bladder cancer diagnosis. In addition, we sought to identify factors that might explain the abnormal cytology classification in cases in which no malignancy was detected. Methods A Total of 855 patients evaluated with urine cytology between 2017 and 2020 at Kuopio University Hospital were included. Histological diagnoses and urinalysis results were correlated with cytology (TPS). Chi-squared and Fisher’s exact tests were used to calculate statistical significance. Results In the absence of exophytic tumors on cystoscopy, the risks of bladder cancer was 0.1% for NHGUC, 1.5% for AUC, 22.7% for SHGUC, and 83.3% for HGUC. Positive urinalysis corresponded to lower cytological diagnostic categories in both males and females. A statistically significant difference was observed in males with respect to moderate pyuria, hematuria, and higher cytological categories. Conclusions This study provides evidence that a biopsy or follow-up may not be necessary for patients without a prior history of urothelial carcinoma and without exophytic tumors observed on cystoscopy, when the cytological diagnosis is NHGUC or AUC. Furthermore, concurrent hematuria and pyuria may result in a higher cytological classification.https://doi.org/10.1007/s12672-025-01828-5The Paris SystemUrothelial carcinomaCytologyCystoscopy |
| spellingShingle | Perttu Saarinen Otto Jokelainen Liida Ruotsalainen Essi Ikonen Timo K. Nykopp The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study Discover Oncology The Paris System Urothelial carcinoma Cytology Cystoscopy |
| title | The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study |
| title_full | The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study |
| title_fullStr | The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study |
| title_full_unstemmed | The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study |
| title_short | The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study |
| title_sort | usage of the paris classification system in urine cytology in the diagnosis of non muscle invasive bladder cancer a retrospective single center study |
| topic | The Paris System Urothelial carcinoma Cytology Cystoscopy |
| url | https://doi.org/10.1007/s12672-025-01828-5 |
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