Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver
The aim of the present study is to investigate the effects of caloric restriction on liver of lead-administered rat. Male Sprague-Dawley rats were randomly divided into two groups: Ad libitum fed group (AL, free access to normal rat chow) and caloric restriction group (CR, fed 65% of AL animals’ foo...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/821524 |
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| author | Mustafa Mohammadi Rana Ghaznavi Rana Keyhanmanesh Hamid Reza Sadeghipour Roya Naderi Hossein Mohammadi |
| author_facet | Mustafa Mohammadi Rana Ghaznavi Rana Keyhanmanesh Hamid Reza Sadeghipour Roya Naderi Hossein Mohammadi |
| author_sort | Mustafa Mohammadi |
| collection | DOAJ |
| description | The aim of the present study is to investigate the effects of caloric restriction on liver of lead-administered rat. Male Sprague-Dawley rats were randomly divided into two groups: Ad libitum fed group (AL, free access to normal rat chow) and caloric restriction group (CR, fed 65% of AL animals’ food intake). After 6 weeks, half of the animals of each group were injected lead acetate and the other half were injected saline. Liver tissue samples were collected at the end of the experiments. Glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured in the tissue extracts. Histological studies were also performed. Our results showed that lead administrations (not saline injections) reduced liver SOD and GPx and increased MDA and TNF-α in AL animals, but in the CR animals lead injections did not significantly change the measured parameters. The histological studies supported the biochemical findings. We concluded that 65% CR may prevent lead-induced oxidative stress and inflammation in rat liver. |
| format | Article |
| id | doaj-art-5685ecf942d54470b608ff8cc3510a96 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5685ecf942d54470b608ff8cc3510a962025-02-03T01:22:47ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/821524821524Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat LiverMustafa Mohammadi0Rana Ghaznavi1Rana Keyhanmanesh2Hamid Reza Sadeghipour3Roya Naderi4Hossein Mohammadi5Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, IranDepartment of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, IranDental School, Tabriz University of Medical Sciences, Tabriz 51656-65814, IranThe aim of the present study is to investigate the effects of caloric restriction on liver of lead-administered rat. Male Sprague-Dawley rats were randomly divided into two groups: Ad libitum fed group (AL, free access to normal rat chow) and caloric restriction group (CR, fed 65% of AL animals’ food intake). After 6 weeks, half of the animals of each group were injected lead acetate and the other half were injected saline. Liver tissue samples were collected at the end of the experiments. Glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured in the tissue extracts. Histological studies were also performed. Our results showed that lead administrations (not saline injections) reduced liver SOD and GPx and increased MDA and TNF-α in AL animals, but in the CR animals lead injections did not significantly change the measured parameters. The histological studies supported the biochemical findings. We concluded that 65% CR may prevent lead-induced oxidative stress and inflammation in rat liver.http://dx.doi.org/10.1155/2014/821524 |
| spellingShingle | Mustafa Mohammadi Rana Ghaznavi Rana Keyhanmanesh Hamid Reza Sadeghipour Roya Naderi Hossein Mohammadi Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver The Scientific World Journal |
| title | Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver |
| title_full | Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver |
| title_fullStr | Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver |
| title_full_unstemmed | Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver |
| title_short | Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver |
| title_sort | caloric restriction prevents lead induced oxidative stress and inflammation in rat liver |
| url | http://dx.doi.org/10.1155/2014/821524 |
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