Glioma Stem Cells: Signaling, Microenvironment, and Therapy
Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7849890 |
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| _version_ | 1832566757053693952 |
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| author | Brandon D. Liebelt Takashi Shingu Xin Zhou Jiangong Ren Seul A. Shin Jian Hu |
| author_facet | Brandon D. Liebelt Takashi Shingu Xin Zhou Jiangong Ren Seul A. Shin Jian Hu |
| author_sort | Brandon D. Liebelt |
| collection | DOAJ |
| description | Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease. GSCs are capable of self-renewal and differentiation; glioblastoma-derived GSCs are capable of de novo tumor formation when implanted in xenograft models. Further, GSCs possess unique surface markers, modulate characteristic signaling pathways to promote tumorigenesis, and play key roles in glioma vascular formation. These features, in addition to microenvironmental factors, present possible targets for specifically directing therapy against the GSC population within glioblastoma. In this review, the authors summarize the current knowledge of GSC biology and function and the role of GSCs in new vascular formation within glioblastoma and discuss potential therapeutic approaches to target GSCs. |
| format | Article |
| id | doaj-art-567eed3baa0b4b0988dff002eda6616d |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-567eed3baa0b4b0988dff002eda6616d2025-02-03T01:03:17ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/78498907849890Glioma Stem Cells: Signaling, Microenvironment, and TherapyBrandon D. Liebelt0Takashi Shingu1Xin Zhou2Jiangong Ren3Seul A. Shin4Jian Hu5Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAGlioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease. GSCs are capable of self-renewal and differentiation; glioblastoma-derived GSCs are capable of de novo tumor formation when implanted in xenograft models. Further, GSCs possess unique surface markers, modulate characteristic signaling pathways to promote tumorigenesis, and play key roles in glioma vascular formation. These features, in addition to microenvironmental factors, present possible targets for specifically directing therapy against the GSC population within glioblastoma. In this review, the authors summarize the current knowledge of GSC biology and function and the role of GSCs in new vascular formation within glioblastoma and discuss potential therapeutic approaches to target GSCs.http://dx.doi.org/10.1155/2016/7849890 |
| spellingShingle | Brandon D. Liebelt Takashi Shingu Xin Zhou Jiangong Ren Seul A. Shin Jian Hu Glioma Stem Cells: Signaling, Microenvironment, and Therapy Stem Cells International |
| title | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
| title_full | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
| title_fullStr | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
| title_full_unstemmed | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
| title_short | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
| title_sort | glioma stem cells signaling microenvironment and therapy |
| url | http://dx.doi.org/10.1155/2016/7849890 |
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