From DNA Radiation Damage to Cell Death: Theoretical Approaches
Some representative models of radiation-induced cell death, which is a crucial endpoint in radiobiology, were reviewed. The basic assumptions were identified, their consequences on predicted cell survival were analyzed, and the advantages and drawbacks of each approach were outlined. In addition to...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/350608 |
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| _version_ | 1832554148848992256 |
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| author | Francesca Ballarini |
| author_facet | Francesca Ballarini |
| author_sort | Francesca Ballarini |
| collection | DOAJ |
| description | Some representative models of radiation-induced cell death, which is a crucial endpoint in radiobiology, were reviewed. The basic assumptions were identified, their consequences on predicted cell survival were analyzed, and the advantages and drawbacks of each approach were outlined. In addition to “historical” approaches such as the Target Theory, the Linear-Quadratic model, the Theory of Dual Radiation Action and Katz' model, the more recent Local Effect Model was discussed, focusing on its application in Carbon-ion hadrontherapy. Furthermore, a mechanistic model developed at the University of Pavia and based on the relationship between cell inactivation and chromosome aberrations was presented, together with recent results; the good agreement between model predictions and literature experimental data on different radiation types (photons, protons, alpha particles, and Carbon ions) supported the idea that asymmetric chromosome aberrations like dicentrics and rings play a fundamental role for cell death. Basing on these results, a reinterpretation of the TDRA was also proposed, identifying the TDRA “sublesions” and “lesions” as clustered DNA double-strand breaks and (lethal) chromosome aberrations, respectively. |
| format | Article |
| id | doaj-art-567b273ac0ff4fe7b1e95acf706fe922 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-567b273ac0ff4fe7b1e95acf706fe9222025-02-03T05:52:17ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/350608350608From DNA Radiation Damage to Cell Death: Theoretical ApproachesFrancesca Ballarini0Department of Nuclear and Theoretical Physics, INFN-Pavia Section, University of Pavia, via Bassi 6, I-27100 Pavia, ItalySome representative models of radiation-induced cell death, which is a crucial endpoint in radiobiology, were reviewed. The basic assumptions were identified, their consequences on predicted cell survival were analyzed, and the advantages and drawbacks of each approach were outlined. In addition to “historical” approaches such as the Target Theory, the Linear-Quadratic model, the Theory of Dual Radiation Action and Katz' model, the more recent Local Effect Model was discussed, focusing on its application in Carbon-ion hadrontherapy. Furthermore, a mechanistic model developed at the University of Pavia and based on the relationship between cell inactivation and chromosome aberrations was presented, together with recent results; the good agreement between model predictions and literature experimental data on different radiation types (photons, protons, alpha particles, and Carbon ions) supported the idea that asymmetric chromosome aberrations like dicentrics and rings play a fundamental role for cell death. Basing on these results, a reinterpretation of the TDRA was also proposed, identifying the TDRA “sublesions” and “lesions” as clustered DNA double-strand breaks and (lethal) chromosome aberrations, respectively.http://dx.doi.org/10.4061/2010/350608 |
| spellingShingle | Francesca Ballarini From DNA Radiation Damage to Cell Death: Theoretical Approaches Journal of Nucleic Acids |
| title | From DNA Radiation Damage to Cell Death: Theoretical Approaches |
| title_full | From DNA Radiation Damage to Cell Death: Theoretical Approaches |
| title_fullStr | From DNA Radiation Damage to Cell Death: Theoretical Approaches |
| title_full_unstemmed | From DNA Radiation Damage to Cell Death: Theoretical Approaches |
| title_short | From DNA Radiation Damage to Cell Death: Theoretical Approaches |
| title_sort | from dna radiation damage to cell death theoretical approaches |
| url | http://dx.doi.org/10.4061/2010/350608 |
| work_keys_str_mv | AT francescaballarini fromdnaradiationdamagetocelldeaththeoreticalapproaches |