Thiazolidinediones on PPARγ: The Roles in Bone Remodeling
Thiazolidinediones (TZDs) are synthetic PPARγ (peroxisome proliferator-activated receptor gamma) agonists and a class of drugs for diabetes mellitus type 2 that can decrease blood sugar efficiently by enhancing insulin sensitivity. However, increased bone fracture risk in diabetic individuals treate...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2011/867180 |
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| _version_ | 1832552159227412480 |
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| author | Wei Wei Yihong Wan |
| author_facet | Wei Wei Yihong Wan |
| author_sort | Wei Wei |
| collection | DOAJ |
| description | Thiazolidinediones (TZDs) are synthetic PPARγ (peroxisome proliferator-activated receptor gamma) agonists and a class of drugs for diabetes mellitus type 2 that can decrease blood sugar efficiently by enhancing insulin sensitivity. However, increased bone fracture risk in diabetic individuals treated with TZDs is one of the reported side effects. Recent studies show that TZDs such as rosiglitazone simultaneously inhibit osteoblast differentiation and activate osteoclast differentiation, leading to bone loss due to decreased bone formation and increased bone resorption. Furthermore, TZDs may activate PPARγ in tissues other than bone, such as the hypothalamus-pituitary-gonad (HPG) axis to indirectly regulate bone mass. This paper will focus on current new developments that implicate potential mechanisms for how PPARγ modulates skeletal homeostasis and how TZDs exert bone-loss side effects. |
| format | Article |
| id | doaj-art-567a364b653a4f648548f1d92fe0417d |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-567a364b653a4f648548f1d92fe0417d2025-02-03T05:59:26ZengWileyPPAR Research1687-47571687-47652011-01-01201110.1155/2011/867180867180Thiazolidinediones on PPARγ: The Roles in Bone RemodelingWei Wei0Yihong Wan1Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USAThiazolidinediones (TZDs) are synthetic PPARγ (peroxisome proliferator-activated receptor gamma) agonists and a class of drugs for diabetes mellitus type 2 that can decrease blood sugar efficiently by enhancing insulin sensitivity. However, increased bone fracture risk in diabetic individuals treated with TZDs is one of the reported side effects. Recent studies show that TZDs such as rosiglitazone simultaneously inhibit osteoblast differentiation and activate osteoclast differentiation, leading to bone loss due to decreased bone formation and increased bone resorption. Furthermore, TZDs may activate PPARγ in tissues other than bone, such as the hypothalamus-pituitary-gonad (HPG) axis to indirectly regulate bone mass. This paper will focus on current new developments that implicate potential mechanisms for how PPARγ modulates skeletal homeostasis and how TZDs exert bone-loss side effects.http://dx.doi.org/10.1155/2011/867180 |
| spellingShingle | Wei Wei Yihong Wan Thiazolidinediones on PPARγ: The Roles in Bone Remodeling PPAR Research |
| title | Thiazolidinediones on PPARγ: The Roles in Bone Remodeling |
| title_full | Thiazolidinediones on PPARγ: The Roles in Bone Remodeling |
| title_fullStr | Thiazolidinediones on PPARγ: The Roles in Bone Remodeling |
| title_full_unstemmed | Thiazolidinediones on PPARγ: The Roles in Bone Remodeling |
| title_short | Thiazolidinediones on PPARγ: The Roles in Bone Remodeling |
| title_sort | thiazolidinediones on pparγ the roles in bone remodeling |
| url | http://dx.doi.org/10.1155/2011/867180 |
| work_keys_str_mv | AT weiwei thiazolidinedionesonppargtherolesinboneremodeling AT yihongwan thiazolidinedionesonppargtherolesinboneremodeling |