Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21

Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21

Abstract Aberrant upregulation of hepatic lipogenesis induced by chronic and excessive alcohol consumption is a critical driver of the progression of alcohol‐associated liver disease (ALD), however, no effective approaches inhibiting lipogenesis are currently available for treating ALD patients. Mor...

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Main Authors: Yang Jiang, Shuang Wei, Shiming Shen, Yuxiao Liu, Weitong Su, Dong Ding, Zengpeng Zheng, Haokai Yu, Tingting Zhang, Qiuli Yang, Jiuxiang Zhao, Yi Shen, Xia Fang, Liangcai Lin, Dongguang Xiao, Aoyuan Cui, Qin Wan, Yadong Zhang, Yu Li, Cuiying Zhang
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
alcohol‐associated liver disease
ethyl lactate
fibroblast growth factor 21
hepatic steatosis
lipogenesis
Online Access:https://doi.org/10.1002/advs.202409516
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