Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease
Objective. To investigate oxidative stress (OS) and histological changes that occur in the periodontium of subjects with type 2 diabetes mellitus without signs of periodontal disease and to establish if oxidative stress is a possible link between diabetes mellitus and periodontal changes. Materials...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/917631 |
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| author | Adriana Monea Tibor Mezei Sorin Popsor Monica Monea |
| author_facet | Adriana Monea Tibor Mezei Sorin Popsor Monica Monea |
| author_sort | Adriana Monea |
| collection | DOAJ |
| description | Objective. To investigate oxidative stress (OS) and histological changes that occur in the periodontium of subjects with type 2 diabetes mellitus without signs of periodontal disease and to establish if oxidative stress is a possible link between diabetes mellitus and periodontal changes. Materials and Methods. Tissue samples from ten adult patients with type 2 diabetes mellitus (T2D) and eight healthy adults were harvested. The specimens were examined by microscope using standard hematoxylin-eosin stain, at various magnifications, and investigated for tissue levels of malondialdehyde (MDA) and glutathione (GSH). Results. Our results showed that periodontal tissues in patients with T2D present significant inflammation, affecting both epithelial and connective tissues. Mean MDA tissue levels were 3.578 ± 0.60 SD in diabetics versus 0.406 ± 0.27 SD in controls (P < 0.0001), while mean GSH tissue levels were 2.48 ± 1.02 SD in diabetics versus 9.7875 ± 2.42 SD in controls (P < 0.0001). Conclusion. Diabetic subjects had higher MDA levels in their periodontal tissues, suggesting an increased lipid peroxidation in T2D, and decreased GSH tissue levels, suggesting an alteration of the local antioxidant defense mechanism. These results are in concordance with the histological changes that we found in periodontal tissues of diabetic subjects, confirming the hypothesis of OS implication, as a correlation between periodontal disease incidence and T2D. |
| format | Article |
| id | doaj-art-566852ccbb8d4d7186554d21815762ae |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-566852ccbb8d4d7186554d21815762ae2025-02-03T06:04:55ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/917631917631Oxidative Stress: A Link between Diabetes Mellitus and Periodontal DiseaseAdriana Monea0Tibor Mezei1Sorin Popsor2Monica Monea3Department of Odontology and Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy Târgu Mureș, 38 Gheorghe Marinescu Street, 540114 Târgu Mureș, RomaniaDepartment of Morphopathology, Faculty of Medicine, University of Medicine and Pharmacy Târgu Mureș, 38 Gheorghe Marinescu Street, 540114 Târgu Mureș, RomaniaDepartment of Prosthetics and Oral Rehabilitation, Faculty of Dental Medicine, University of Medicine and Pharmacy Târgu Mureș, 38 Gheorghe Marinescu Street, 540114 Târgu Mureș, RomaniaDepartment of Odontology and Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy Târgu Mureș, 38 Gheorghe Marinescu Street, 540114 Târgu Mureș, RomaniaObjective. To investigate oxidative stress (OS) and histological changes that occur in the periodontium of subjects with type 2 diabetes mellitus without signs of periodontal disease and to establish if oxidative stress is a possible link between diabetes mellitus and periodontal changes. Materials and Methods. Tissue samples from ten adult patients with type 2 diabetes mellitus (T2D) and eight healthy adults were harvested. The specimens were examined by microscope using standard hematoxylin-eosin stain, at various magnifications, and investigated for tissue levels of malondialdehyde (MDA) and glutathione (GSH). Results. Our results showed that periodontal tissues in patients with T2D present significant inflammation, affecting both epithelial and connective tissues. Mean MDA tissue levels were 3.578 ± 0.60 SD in diabetics versus 0.406 ± 0.27 SD in controls (P < 0.0001), while mean GSH tissue levels were 2.48 ± 1.02 SD in diabetics versus 9.7875 ± 2.42 SD in controls (P < 0.0001). Conclusion. Diabetic subjects had higher MDA levels in their periodontal tissues, suggesting an increased lipid peroxidation in T2D, and decreased GSH tissue levels, suggesting an alteration of the local antioxidant defense mechanism. These results are in concordance with the histological changes that we found in periodontal tissues of diabetic subjects, confirming the hypothesis of OS implication, as a correlation between periodontal disease incidence and T2D.http://dx.doi.org/10.1155/2014/917631 |
| spellingShingle | Adriana Monea Tibor Mezei Sorin Popsor Monica Monea Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease International Journal of Endocrinology |
| title | Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease |
| title_full | Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease |
| title_fullStr | Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease |
| title_full_unstemmed | Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease |
| title_short | Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease |
| title_sort | oxidative stress a link between diabetes mellitus and periodontal disease |
| url | http://dx.doi.org/10.1155/2014/917631 |
| work_keys_str_mv | AT adrianamonea oxidativestressalinkbetweendiabetesmellitusandperiodontaldisease AT tibormezei oxidativestressalinkbetweendiabetesmellitusandperiodontaldisease AT sorinpopsor oxidativestressalinkbetweendiabetesmellitusandperiodontaldisease AT monicamonea oxidativestressalinkbetweendiabetesmellitusandperiodontaldisease |