The chemistry of gut microbiome in health and diseases
There are trillions of microbes residing in our body, with their collective genomes much more than human genomes. They have been living in a close relationship with us and play a role in various biological functions. The human microbes begin to build up in utero, accumulate, and fluctuate until a s...
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| Format: | Article |
| Language: | English |
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HH Publisher
2021-02-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/379 |
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| author | Agnes Wei Yin Lau Loh Teng-Hern Tan Nurul-Syakima Ab Mutalib Sunny Hei Wong Vengadesh Letchumanan Learn-Han Lee |
| author_facet | Agnes Wei Yin Lau Loh Teng-Hern Tan Nurul-Syakima Ab Mutalib Sunny Hei Wong Vengadesh Letchumanan Learn-Han Lee |
| author_sort | Agnes Wei Yin Lau |
| collection | DOAJ |
| description |
There are trillions of microbes residing in our body, with their collective genomes much more than human genomes. They have been living in a close relationship with us and play a role in various biological functions. The human microbes begin to build up in utero, accumulate, and fluctuate until a set point is achieved around three years of age. The gut microbiome is altered by several factors, which include age, diet, and antibiotic use. After the exposure, the microbe may shift back to retain its balance, but some factors may leave a permanent footprint on the gut flora. This may be significant as our review has shown the relationships between microbes and diseases. When the homeostasis of gut-microbes is disrupted, multiple mechanisms have been shown to contribute to diseases' development. The balance between protective and pathogenic microbes must be kept in check to prevent disease onset. With a better understanding of this relationship, we will investigate the potential methods to modify the gut flora as the background of developing therapeutic options. There are already some therapeutic options such as prebiotics, probiotics, and fecal transplantation, but their clinical use is limited and restricted. Therefore, there is still a need to investigate the characteristic microbiome association with gut-dysbiosis-related diseases, which may help manage the disease and develop diagnostic and monitoring tools. This review aims to discuss our gut microbiome and its association with human health and diseases.
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| format | Article |
| id | doaj-art-565424b9ec4d45b0bf8dc0e7a9cfd0e6 |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-565424b9ec4d45b0bf8dc0e7a9cfd0e62025-02-04T08:36:58ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492021-02-014110.36877/pmmb.a0000175The chemistry of gut microbiome in health and diseasesAgnes Wei Yin LauLoh Teng-Hern TanNurul-Syakima Ab MutalibSunny Hei WongVengadesh LetchumananLearn-Han Lee There are trillions of microbes residing in our body, with their collective genomes much more than human genomes. They have been living in a close relationship with us and play a role in various biological functions. The human microbes begin to build up in utero, accumulate, and fluctuate until a set point is achieved around three years of age. The gut microbiome is altered by several factors, which include age, diet, and antibiotic use. After the exposure, the microbe may shift back to retain its balance, but some factors may leave a permanent footprint on the gut flora. This may be significant as our review has shown the relationships between microbes and diseases. When the homeostasis of gut-microbes is disrupted, multiple mechanisms have been shown to contribute to diseases' development. The balance between protective and pathogenic microbes must be kept in check to prevent disease onset. With a better understanding of this relationship, we will investigate the potential methods to modify the gut flora as the background of developing therapeutic options. There are already some therapeutic options such as prebiotics, probiotics, and fecal transplantation, but their clinical use is limited and restricted. Therefore, there is still a need to investigate the characteristic microbiome association with gut-dysbiosis-related diseases, which may help manage the disease and develop diagnostic and monitoring tools. This review aims to discuss our gut microbiome and its association with human health and diseases. https://journals.hh-publisher.com/index.php/pmmb/article/view/379 |
| spellingShingle | Agnes Wei Yin Lau Loh Teng-Hern Tan Nurul-Syakima Ab Mutalib Sunny Hei Wong Vengadesh Letchumanan Learn-Han Lee The chemistry of gut microbiome in health and diseases Progress in Microbes and Molecular Biology |
| title | The chemistry of gut microbiome in health and diseases |
| title_full | The chemistry of gut microbiome in health and diseases |
| title_fullStr | The chemistry of gut microbiome in health and diseases |
| title_full_unstemmed | The chemistry of gut microbiome in health and diseases |
| title_short | The chemistry of gut microbiome in health and diseases |
| title_sort | chemistry of gut microbiome in health and diseases |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/379 |
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