Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody
Background and purpose: Although carbon-ion radiotherapy (CIRT) has led to good outcomes, controlling metastasis is still crucial for improving overall survival. This study aimed to evaluate the effectiveness of by two combinations, one of CIRT and anti-CTLA4 antibody, the other of CIRT and anti-PD-...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558624001404 |
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| author | Liqiu Ma Yang Li Yoshimitsu Sakamoto Lin Xie Saaya Suzuki Yukari Yoshida Li Sui Gang Guo Jialing Wen Wangcai Ren Kazuhiro Kakimi Kensuke Osada Akihisa Takahashi Takashi Shimokawa |
| author_facet | Liqiu Ma Yang Li Yoshimitsu Sakamoto Lin Xie Saaya Suzuki Yukari Yoshida Li Sui Gang Guo Jialing Wen Wangcai Ren Kazuhiro Kakimi Kensuke Osada Akihisa Takahashi Takashi Shimokawa |
| author_sort | Liqiu Ma |
| collection | DOAJ |
| description | Background and purpose: Although carbon-ion radiotherapy (CIRT) has led to good outcomes, controlling metastasis is still crucial for improving overall survival. This study aimed to evaluate the effectiveness of by two combinations, one of CIRT and anti-CTLA4 antibody, the other of CIRT and anti-PD-1 antibody, applied at different radiation doses for distal tumour and metastasis suppression. Materials and methods: Murine cancer cells (colon carcinoma Colon-26 cells for experiments and osteosarcoma LM8 cells for verification) were grafted into both sides of the hind legs of syngeneic mice. Right-side tumours were irradiated with 3 Gy or 10 Gy CIRT while the left-side tumours were not irradiated, followed by the administration of the anti-CTLA4 antibody or anti-PD-1 antibody. The diameter of the tumours in both legs was measured 3 times per week after irradiation. The number of pulmonary metastases was evaluated within 3 weeks after irradiation. Results: Compared with the control group, the high-dose group showed promising anti-cancer benefits in terms of both irradiated tumours and lung metastasis, but neither 10 Gy CIRT combined with the anti-CTLA4 antibody nor 10 Gy CIRT combined with the anti-PD-1 antibody suppressed the growth of distant unirradiated tumours. In the low-dose group, the effect on primary tumour control was slightly weaker than that in the high-dose treatment group, but significant suppressive effects on both distant unirradiated tumours and metastases were observed following 3 Gy CIRT combined with anti-CTLA4 antibody treatment. Specifically, the volume of distant unirradiated tumours decreased by 40 % compared with that of the control group, and no lung metastasis was observed. Conclusion: Our findings suggest that there is an optimal dose range for the abscopal effect generated with the CIRT combined with anti-CTLA4 antibody, and it highlights a new opportunity for increased induction efficiency of the abscopal effect of combination therapy. |
| format | Article |
| id | doaj-art-564d3fefb5fc4ce69f83457e0bd9b735 |
| institution | Kabale University |
| issn | 1476-5586 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj-art-564d3fefb5fc4ce69f83457e0bd9b7352025-02-03T04:16:32ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862025-02-0160101099Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibodyLiqiu Ma0Yang Li1Yoshimitsu Sakamoto2Lin Xie3Saaya Suzuki4Yukari Yoshida5Li Sui6Gang Guo7Jialing Wen8Wangcai Ren9Kazuhiro Kakimi10Kensuke Osada11Akihisa Takahashi12Takashi Shimokawa13Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan; Gunma University Heavy Ion Medical Center, Gunma 371-8511, Japan; Department of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413, China; Corresponding authors at: National Institutes for Quantum Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan.Gunma University Heavy Ion Medical Center, Gunma 371-8511, JapanInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, JapanInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, JapanInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, JapanGunma University Heavy Ion Medical Center, Gunma 371-8511, JapanDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413, ChinaDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413, ChinaDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413, ChinaDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413, ChinaDepartment of Immunology, Kindai University Faculty of Medicine, Osaka 589-0014, JapanInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, JapanGunma University Heavy Ion Medical Center, Gunma 371-8511, JapanInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan; Corresponding authors at: National Institutes for Quantum Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan.Background and purpose: Although carbon-ion radiotherapy (CIRT) has led to good outcomes, controlling metastasis is still crucial for improving overall survival. This study aimed to evaluate the effectiveness of by two combinations, one of CIRT and anti-CTLA4 antibody, the other of CIRT and anti-PD-1 antibody, applied at different radiation doses for distal tumour and metastasis suppression. Materials and methods: Murine cancer cells (colon carcinoma Colon-26 cells for experiments and osteosarcoma LM8 cells for verification) were grafted into both sides of the hind legs of syngeneic mice. Right-side tumours were irradiated with 3 Gy or 10 Gy CIRT while the left-side tumours were not irradiated, followed by the administration of the anti-CTLA4 antibody or anti-PD-1 antibody. The diameter of the tumours in both legs was measured 3 times per week after irradiation. The number of pulmonary metastases was evaluated within 3 weeks after irradiation. Results: Compared with the control group, the high-dose group showed promising anti-cancer benefits in terms of both irradiated tumours and lung metastasis, but neither 10 Gy CIRT combined with the anti-CTLA4 antibody nor 10 Gy CIRT combined with the anti-PD-1 antibody suppressed the growth of distant unirradiated tumours. In the low-dose group, the effect on primary tumour control was slightly weaker than that in the high-dose treatment group, but significant suppressive effects on both distant unirradiated tumours and metastases were observed following 3 Gy CIRT combined with anti-CTLA4 antibody treatment. Specifically, the volume of distant unirradiated tumours decreased by 40 % compared with that of the control group, and no lung metastasis was observed. Conclusion: Our findings suggest that there is an optimal dose range for the abscopal effect generated with the CIRT combined with anti-CTLA4 antibody, and it highlights a new opportunity for increased induction efficiency of the abscopal effect of combination therapy.http://www.sciencedirect.com/science/article/pii/S1476558624001404Heavy ionAbscopal effectCarbon-ion radiotherapy (CIRT)MetastasisAnti-CTLA4 antibody |
| spellingShingle | Liqiu Ma Yang Li Yoshimitsu Sakamoto Lin Xie Saaya Suzuki Yukari Yoshida Li Sui Gang Guo Jialing Wen Wangcai Ren Kazuhiro Kakimi Kensuke Osada Akihisa Takahashi Takashi Shimokawa Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody Neoplasia: An International Journal for Oncology Research Heavy ion Abscopal effect Carbon-ion radiotherapy (CIRT) Metastasis Anti-CTLA4 antibody |
| title | Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody |
| title_full | Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody |
| title_fullStr | Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody |
| title_full_unstemmed | Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody |
| title_short | Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody |
| title_sort | optimal radiation dose to induce an abscopal effect by combining carbon ion radiotherapy and anti ctla4 antibody |
| topic | Heavy ion Abscopal effect Carbon-ion radiotherapy (CIRT) Metastasis Anti-CTLA4 antibody |
| url | http://www.sciencedirect.com/science/article/pii/S1476558624001404 |
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