Achieving Hepatitis C Micro-Elimination in Chinese Injecting Drug Users: A Dynamic Network Modeling Study
Abstract Introduction The World Health Organization (WHO) has established objectives for eradicating the hepatitis C virus (HCV). People who inject drugs (PWID), a major driver of HCV transmission, are an essential part of China’s hepatitis C elimination program. This study aimed to estimate the req...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2024-12-01
|
| Series: | Infectious Diseases and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40121-024-01084-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571443184926720 |
|---|---|
| author | Ying Chen Yun Bao Mengxia Yan Huajie Jin Kaijie Yao Chi Zhang Wen Li Bin Wu |
| author_facet | Ying Chen Yun Bao Mengxia Yan Huajie Jin Kaijie Yao Chi Zhang Wen Li Bin Wu |
| author_sort | Ying Chen |
| collection | DOAJ |
| description | Abstract Introduction The World Health Organization (WHO) has established objectives for eradicating the hepatitis C virus (HCV). People who inject drugs (PWID), a major driver of HCV transmission, are an essential part of China’s hepatitis C elimination program. This study aimed to estimate the requisite screening and antiviral treatment levels to achieve these goals among people who inject drugs in China and identify the most cost-effective strategy. Methods This study utilized models based on dynamic social networks to simulate HCV transmission and disease progression among people who inject drugs in China, incorporating a cost-effectiveness analysis from a healthcare perspective. Results To achieve the WHO targets, a minimum screening and treatment rate of 10% is required to meet the mortality goal, while a 25% rate is necessary for the incidence goal. The most cost-effective strategy includes a 25% screening rate and a 95% treatment rate. Compared to no intervention, this approach significantly reduces costs by − $85,873.38 (95% CI − $94,311.16 to − $77,435.59) and adds 24.66 (95% CI 23.68 to – 25.64) quality-adjusted life years. The intervention is dominant, with a cost-effectiveness ratio of − $3482.29 (95% CI − $3982.73 to − $3020.11) per quality-adjusted life year. Conclusion Achieving the WHO’s hepatitis C virus elimination targets among people who inject drugs in China is feasible and cost-saving. |
| format | Article |
| id | doaj-art-56394e1dd1f34c1da6c6001a2816c2b0 |
| institution | Kabale University |
| issn | 2193-8229 2193-6382 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj-art-56394e1dd1f34c1da6c6001a2816c2b02025-02-02T12:35:25ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822024-12-0114118119710.1007/s40121-024-01084-0Achieving Hepatitis C Micro-Elimination in Chinese Injecting Drug Users: A Dynamic Network Modeling StudyYing Chen0Yun Bao1Mengxia Yan2Huajie Jin3Kaijie Yao4Chi Zhang5Wen Li6Bin Wu7Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of MedicineWest China School of Pharmacy, Sichuan UniversityDepartment of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of MedicineKing’s Health Economics (KHE), Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonDepartment of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pharmacy, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pharmacy, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of MedicineAbstract Introduction The World Health Organization (WHO) has established objectives for eradicating the hepatitis C virus (HCV). People who inject drugs (PWID), a major driver of HCV transmission, are an essential part of China’s hepatitis C elimination program. This study aimed to estimate the requisite screening and antiviral treatment levels to achieve these goals among people who inject drugs in China and identify the most cost-effective strategy. Methods This study utilized models based on dynamic social networks to simulate HCV transmission and disease progression among people who inject drugs in China, incorporating a cost-effectiveness analysis from a healthcare perspective. Results To achieve the WHO targets, a minimum screening and treatment rate of 10% is required to meet the mortality goal, while a 25% rate is necessary for the incidence goal. The most cost-effective strategy includes a 25% screening rate and a 95% treatment rate. Compared to no intervention, this approach significantly reduces costs by − $85,873.38 (95% CI − $94,311.16 to − $77,435.59) and adds 24.66 (95% CI 23.68 to – 25.64) quality-adjusted life years. The intervention is dominant, with a cost-effectiveness ratio of − $3482.29 (95% CI − $3982.73 to − $3020.11) per quality-adjusted life year. Conclusion Achieving the WHO’s hepatitis C virus elimination targets among people who inject drugs in China is feasible and cost-saving.https://doi.org/10.1007/s40121-024-01084-0Hepatitis C virusDirect-acting antiviralsSocial networkPeople who inject drugsCost-effectiveness analysis |
| spellingShingle | Ying Chen Yun Bao Mengxia Yan Huajie Jin Kaijie Yao Chi Zhang Wen Li Bin Wu Achieving Hepatitis C Micro-Elimination in Chinese Injecting Drug Users: A Dynamic Network Modeling Study Infectious Diseases and Therapy Hepatitis C virus Direct-acting antivirals Social network People who inject drugs Cost-effectiveness analysis |
| title | Achieving Hepatitis C Micro-Elimination in Chinese Injecting Drug Users: A Dynamic Network Modeling Study |
| title_full | Achieving Hepatitis C Micro-Elimination in Chinese Injecting Drug Users: A Dynamic Network Modeling Study |
| title_fullStr | Achieving Hepatitis C Micro-Elimination in Chinese Injecting Drug Users: A Dynamic Network Modeling Study |
| title_full_unstemmed | Achieving Hepatitis C Micro-Elimination in Chinese Injecting Drug Users: A Dynamic Network Modeling Study |
| title_short | Achieving Hepatitis C Micro-Elimination in Chinese Injecting Drug Users: A Dynamic Network Modeling Study |
| title_sort | achieving hepatitis c micro elimination in chinese injecting drug users a dynamic network modeling study |
| topic | Hepatitis C virus Direct-acting antivirals Social network People who inject drugs Cost-effectiveness analysis |
| url | https://doi.org/10.1007/s40121-024-01084-0 |
| work_keys_str_mv | AT yingchen achievinghepatitiscmicroeliminationinchineseinjectingdrugusersadynamicnetworkmodelingstudy AT yunbao achievinghepatitiscmicroeliminationinchineseinjectingdrugusersadynamicnetworkmodelingstudy AT mengxiayan achievinghepatitiscmicroeliminationinchineseinjectingdrugusersadynamicnetworkmodelingstudy AT huajiejin achievinghepatitiscmicroeliminationinchineseinjectingdrugusersadynamicnetworkmodelingstudy AT kaijieyao achievinghepatitiscmicroeliminationinchineseinjectingdrugusersadynamicnetworkmodelingstudy AT chizhang achievinghepatitiscmicroeliminationinchineseinjectingdrugusersadynamicnetworkmodelingstudy AT wenli achievinghepatitiscmicroeliminationinchineseinjectingdrugusersadynamicnetworkmodelingstudy AT binwu achievinghepatitiscmicroeliminationinchineseinjectingdrugusersadynamicnetworkmodelingstudy |