Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study

Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study

Abstract Hypertrophic scars (HS), classified as abnormal scarring, result from an overactive tissue response during wound healing following dermal trauma. Nonetheless, the precise mechanistic pathway underlying its occurrence remains elusive. The principal aim of this study is to elucidate the causa...

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Bibliographic Details
Main Authors: Jiaqi Lou, Ziyi Xiang, Xiaoyu Zhu, Jiliang Li, Guoying Jin, Shengyong Cui, Neng Huang, Pei Xu, Sida Xu, Youfen Fan, Xin Le
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Gut microbiota
Immune cells
Hypertrophic scar
Mendelian randomization
Two-step analysis
Online Access:https://doi.org/10.1038/s41598-025-07455-y
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