Neutrophils and neutrophil extracellular traps in oral health and disease
Abstract Neutrophils perform essential functions in antimicrobial defense and tissue maintenance at mucosal barriers. However, a dysregulated neutrophil response and, in particular, the excessive release of neutrophil extracellular traps (NETs) are implicated in the pathology of various diseases. In...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-05-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-024-01219-w |
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| _version_ | 1832572001036795904 |
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| author | Tae Sung Kim Niki M. Moutsopoulos |
| author_facet | Tae Sung Kim Niki M. Moutsopoulos |
| author_sort | Tae Sung Kim |
| collection | DOAJ |
| description | Abstract Neutrophils perform essential functions in antimicrobial defense and tissue maintenance at mucosal barriers. However, a dysregulated neutrophil response and, in particular, the excessive release of neutrophil extracellular traps (NETs) are implicated in the pathology of various diseases. In this review, we provide an overview of the basic concepts related to neutrophil functions, including NET formation, and discuss the mechanisms associated with NET activation and function in the context of the prevalent oral disease periodontitis. |
| format | Article |
| id | doaj-art-5620c10a5662494eb26e593bc6dff10e |
| institution | Kabale University |
| issn | 2092-6413 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj-art-5620c10a5662494eb26e593bc6dff10e2025-02-02T12:10:23ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132024-05-015651055106510.1038/s12276-024-01219-wNeutrophils and neutrophil extracellular traps in oral health and diseaseTae Sung Kim0Niki M. Moutsopoulos1Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, National Institutes of HealthOral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, National Institutes of HealthAbstract Neutrophils perform essential functions in antimicrobial defense and tissue maintenance at mucosal barriers. However, a dysregulated neutrophil response and, in particular, the excessive release of neutrophil extracellular traps (NETs) are implicated in the pathology of various diseases. In this review, we provide an overview of the basic concepts related to neutrophil functions, including NET formation, and discuss the mechanisms associated with NET activation and function in the context of the prevalent oral disease periodontitis.https://doi.org/10.1038/s12276-024-01219-w |
| spellingShingle | Tae Sung Kim Niki M. Moutsopoulos Neutrophils and neutrophil extracellular traps in oral health and disease Experimental and Molecular Medicine |
| title | Neutrophils and neutrophil extracellular traps in oral health and disease |
| title_full | Neutrophils and neutrophil extracellular traps in oral health and disease |
| title_fullStr | Neutrophils and neutrophil extracellular traps in oral health and disease |
| title_full_unstemmed | Neutrophils and neutrophil extracellular traps in oral health and disease |
| title_short | Neutrophils and neutrophil extracellular traps in oral health and disease |
| title_sort | neutrophils and neutrophil extracellular traps in oral health and disease |
| url | https://doi.org/10.1038/s12276-024-01219-w |
| work_keys_str_mv | AT taesungkim neutrophilsandneutrophilextracellulartrapsinoralhealthanddisease AT nikimmoutsopoulos neutrophilsandneutrophilextracellulartrapsinoralhealthanddisease |